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Article: The adrenergic neuroeffector interaction in the normotensive and hypertensive blood vessel wall

TitleThe adrenergic neuroeffector interaction in the normotensive and hypertensive blood vessel wall
Authors
Issue Date1980
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 1980, v. 2 Suppl.3, p. S253-S267 How to Cite?
AbstractThe data available indicate that, in particular, in the spontaneous hypertensive rat, the early stages of the hypertensive process are characterised by a hyperfunction of the peripheral adrenergic nerve varicosities, which results in an enhanced release of adrenergic neurotransmitter; this may be an important factor in increasing peripheral resistance and initiating the hypertension. In sustained hypertension, changes in the disposition of neuronally released norepinephrine have occurred, in particular an acceleration of the neuronal uptake process. This results in a relative reduction of the vasoconstrictor responses to sympathetic nerve stimulation, which compensates in part for the increase in vascular smooth muscle reactivity; this in turn is the consequence of the chronic exposure of the blood vessels to the high blood pressure.
Persistent Identifierhttp://hdl.handle.net/10722/170622
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:10Z-
dc.date.available2012-10-30T06:10:10Z-
dc.date.issued1980en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 1980, v. 2 Suppl.3, p. S253-S267en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/170622-
dc.description.abstractThe data available indicate that, in particular, in the spontaneous hypertensive rat, the early stages of the hypertensive process are characterised by a hyperfunction of the peripheral adrenergic nerve varicosities, which results in an enhanced release of adrenergic neurotransmitter; this may be an important factor in increasing peripheral resistance and initiating the hypertension. In sustained hypertension, changes in the disposition of neuronally released norepinephrine have occurred, in particular an acceleration of the neuronal uptake process. This results in a relative reduction of the vasoconstrictor responses to sympathetic nerve stimulation, which compensates in part for the increase in vascular smooth muscle reactivity; this in turn is the consequence of the chronic exposure of the blood vessels to the high blood pressure.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.titleThe adrenergic neuroeffector interaction in the normotensive and hypertensive blood vessel wallen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0019275314en_US
dc.identifier.volume2en_US
dc.identifier.issueSuppl.3en_US
dc.identifier.spageS253en_US
dc.identifier.epageS267en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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