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Article: Effect of BL-5111-A, prazosin and phentolamine on responses of canine cutaneous veins to adrenergic activation

TitleEffect of BL-5111-A, prazosin and phentolamine on responses of canine cutaneous veins to adrenergic activation
Authors
Issue Date1980
Citation
Archives Internationales De Pharmacodynamie Et De Therapie, 1980, v. 244 n. 2, p. 341-343 How to Cite?
AbstractBL-5111-A, 4-amino-6,7-dimethoxy-2-[4-(5-methylthio-1,3,4-oxadiazole-2-carbonyl)-piperazin-1-yl] quinazoline hydrochloride, is a novel alpha-adrenolytic drug with antihypertensive properties in the intact animal. In the present study, the alpha-adrenolytic properties of BL-5111-A were compared with those of phentolamine and prazosin, using cutaneous veins of the dog as a model of adrenergically innervated vascular smooth muscle.
Persistent Identifierhttp://hdl.handle.net/10722/170620
ISSN
1998 Impact Factor: 0.72
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRusch, NJen_US
dc.contributor.authorDe Mey, JGen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:10Z-
dc.date.available2012-10-30T06:10:10Z-
dc.date.issued1980en_US
dc.identifier.citationArchives Internationales De Pharmacodynamie Et De Therapie, 1980, v. 244 n. 2, p. 341-343en_US
dc.identifier.issn0003-9780en_US
dc.identifier.urihttp://hdl.handle.net/10722/170620-
dc.description.abstractBL-5111-A, 4-amino-6,7-dimethoxy-2-[4-(5-methylthio-1,3,4-oxadiazole-2-carbonyl)-piperazin-1-yl] quinazoline hydrochloride, is a novel alpha-adrenolytic drug with antihypertensive properties in the intact animal. In the present study, the alpha-adrenolytic properties of BL-5111-A were compared with those of phentolamine and prazosin, using cutaneous veins of the dog as a model of adrenergically innervated vascular smooth muscle.en_US
dc.languageengen_US
dc.relation.ispartofArchives Internationales de Pharmacodynamie et de Therapieen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCocaine - Antagonists & Inhibitorsen_US
dc.subject.meshDogsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Antagonismen_US
dc.subject.meshEstradiolen_US
dc.subject.meshEstradiol Antagonistsen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Physiologyen_US
dc.subject.meshNorepinephrine - Antagonists & Inhibitorsen_US
dc.subject.meshPhentolamine - Pharmacologyen_US
dc.subject.meshPrazosin - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshPropranolol - Antagonists & Inhibitorsen_US
dc.subject.meshQuinazolines - Pharmacologyen_US
dc.subject.meshSaphenous Vein - Physiologyen_US
dc.subject.meshSympathomimetics - Antagonists & Inhibitorsen_US
dc.titleEffect of BL-5111-A, prazosin and phentolamine on responses of canine cutaneous veins to adrenergic activationen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7406593-
dc.identifier.scopuseid_2-s2.0-0019224285en_US
dc.identifier.volume244en_US
dc.identifier.issue2en_US
dc.identifier.spage341en_US
dc.identifier.epage343en_US
dc.identifier.isiWOS:A1980JY74700021-
dc.identifier.scopusauthoridRusch, NJ=7005728816en_US
dc.identifier.scopusauthoridDe Mey, JG=7101918486en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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