File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Scopus: eid_2-s2.0-0018755712
- PMID: 315681
- WOS: WOS:A1979HC73100003
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Intermittent claudication - pathophysiological considerations
Title | Intermittent claudication - pathophysiological considerations |
---|---|
Authors | |
Issue Date | 1979 |
Citation | Acta Cardiologica, 1979, v. 34 n. 3, p. 125-132 How to Cite? |
Abstract | Intermittent claudication is a non-pathognomic symptom elicited by an imbalance between the metabolic demands of the exercising skeletal muscle and its blood supply. In normal conditions hyperemia to the working muscles will be impaired during the exercise by mechanical compression of the microvessels. The resulting anaerobic metabolism will cause further vasodilatation. Both phenomena (exercise and reactive hyperemia) contribute to a maximal increase in local blood flow as soon as the exercise is stopped. If the local circulation is impaired by occluding arterial disease (eventually complicated by aggravating factors) the tolerance to skeletal work is lowered and the circulatory reserves are entirely exhausted as demonstrated by the ischemic exercise-test. In the case of a major obstruction and poor collateralisation, a 'steal phenomenon' may occur. The pharmacotherapeutic possibilities to cope with in this situation are briefly discussed. |
Persistent Identifier | http://hdl.handle.net/10722/170595 |
ISSN | 2021 Impact Factor: 1.738 2020 SCImago Journal Rankings: 0.348 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Vanhoutte, PM | en_US |
dc.contributor.author | De Mey Ch | en_US |
dc.contributor.author | Wellens, D | en_US |
dc.date.accessioned | 2012-10-30T06:10:04Z | - |
dc.date.available | 2012-10-30T06:10:04Z | - |
dc.date.issued | 1979 | en_US |
dc.identifier.citation | Acta Cardiologica, 1979, v. 34 n. 3, p. 125-132 | en_US |
dc.identifier.issn | 0001-5385 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170595 | - |
dc.description.abstract | Intermittent claudication is a non-pathognomic symptom elicited by an imbalance between the metabolic demands of the exercising skeletal muscle and its blood supply. In normal conditions hyperemia to the working muscles will be impaired during the exercise by mechanical compression of the microvessels. The resulting anaerobic metabolism will cause further vasodilatation. Both phenomena (exercise and reactive hyperemia) contribute to a maximal increase in local blood flow as soon as the exercise is stopped. If the local circulation is impaired by occluding arterial disease (eventually complicated by aggravating factors) the tolerance to skeletal work is lowered and the circulatory reserves are entirely exhausted as demonstrated by the ischemic exercise-test. In the case of a major obstruction and poor collateralisation, a 'steal phenomenon' may occur. The pharmacotherapeutic possibilities to cope with in this situation are briefly discussed. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Acta Cardiologica | en_US |
dc.subject.mesh | Adenosine Triphosphate - Metabolism | en_US |
dc.subject.mesh | Collateral Circulation | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Intermittent Claudication - Metabolism - Physiopathology | en_US |
dc.subject.mesh | Muscle Contraction | en_US |
dc.subject.mesh | Muscles - Blood Supply - Metabolism | en_US |
dc.subject.mesh | Oxygen - Blood | en_US |
dc.subject.mesh | Regional Blood Flow | en_US |
dc.title | Intermittent claudication - pathophysiological considerations | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 315681 | - |
dc.identifier.scopus | eid_2-s2.0-0018755712 | en_US |
dc.identifier.volume | 34 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 125 | en_US |
dc.identifier.epage | 132 | en_US |
dc.identifier.isi | WOS:A1979HC73100003 | - |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.scopusauthorid | De Mey Ch=7006663615 | en_US |
dc.identifier.scopusauthorid | Wellens, D=7003866572 | en_US |
dc.identifier.issnl | 0001-5385 | - |