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Article: A specific effect of lidocaine and tocainide on ventricular conduction of mid-range extrasystoles

TitleA specific effect of lidocaine and tocainide on ventricular conduction of mid-range extrasystoles
Authors
Issue Date1979
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 1979, v. 1 n. 3, p. 329-342 How to Cite?
AbstractLidocaine and tocainide had no effect on ventricular conduction of extrasystoles with coupling intervals longer than 500 msec in isolated blood-perfused dog hearts, but caused interval-related increases in conduction time of extrasystoles in the range of 250-400 msec, here called mid-range extrasystoles (MRE). Quinidine, procainamide, disopyramide, and methyl lidocaine increased conduction times of extrasystoles at all coupling intervals, and no additional slowing of MRE was observed. The slowing of MRE specific to lidocaine and tocainide was confirmed in the intact dog heart. During acute myocardial ischemia in the intact dog heart, conduction was slowed and additional slowing of MRE was found. Lidocaine and tocainide caused further slowing of conduction of MRE. This unique effect of lidocaine and tocainide on the conduction of MRE may be important in the suppression of the reentrant arrhythmias. However, lidocaine and tocainide were also found to be arrhythmogenic when extrasystoles were introduced, after acute coronary occlusion, in those animals in which such occlusion alone did not allow demonstration of arrhythmias due to extrasystoles.
Persistent Identifierhttp://hdl.handle.net/10722/170591
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMan, RYKen_US
dc.contributor.authorDresel, PEen_US
dc.date.accessioned2012-10-30T06:10:04Z-
dc.date.available2012-10-30T06:10:04Z-
dc.date.issued1979en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 1979, v. 1 n. 3, p. 329-342en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/170591-
dc.description.abstractLidocaine and tocainide had no effect on ventricular conduction of extrasystoles with coupling intervals longer than 500 msec in isolated blood-perfused dog hearts, but caused interval-related increases in conduction time of extrasystoles in the range of 250-400 msec, here called mid-range extrasystoles (MRE). Quinidine, procainamide, disopyramide, and methyl lidocaine increased conduction times of extrasystoles at all coupling intervals, and no additional slowing of MRE was observed. The slowing of MRE specific to lidocaine and tocainide was confirmed in the intact dog heart. During acute myocardial ischemia in the intact dog heart, conduction was slowed and additional slowing of MRE was found. Lidocaine and tocainide caused further slowing of conduction of MRE. This unique effect of lidocaine and tocainide on the conduction of MRE may be important in the suppression of the reentrant arrhythmias. However, lidocaine and tocainide were also found to be arrhythmogenic when extrasystoles were introduced, after acute coronary occlusion, in those animals in which such occlusion alone did not allow demonstration of arrhythmias due to extrasystoles.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subject.meshAnilides - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Arrhythmia Agents - Pharmacologyen_US
dc.subject.meshCardiac Complexes, Premature - Physiopathologyen_US
dc.subject.meshCoronary Disease - Physiopathologyen_US
dc.subject.meshCoronary Vessels - Physiologyen_US
dc.subject.meshDogsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshHeart Conduction System - Drug Effectsen_US
dc.subject.meshLidocaine - Pharmacologyen_US
dc.subject.meshQuinidine - Pharmacologyen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTocainideen_US
dc.titleA specific effect of lidocaine and tocainide on ventricular conduction of mid-range extrasystolesen_US
dc.typeArticleen_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00005344-197905000-00005-
dc.identifier.pmid94400-
dc.identifier.scopuseid_2-s2.0-0018635046en_US
dc.identifier.volume1en_US
dc.identifier.issue3en_US
dc.identifier.spage329en_US
dc.identifier.epage342en_US
dc.identifier.isiWOS:A1979GX97200005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US
dc.identifier.scopusauthoridDresel, PE=7004058750en_US

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