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- Scopus: eid_2-s2.0-0018392008
- PMID: 223855
- WOS: WOS:A1979GX84700008
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Article: Modulation of the evoked release of noradrenaline in canine saphenous vein via presynaptic receptors for adenosine but not ATP
Title | Modulation of the evoked release of noradrenaline in canine saphenous vein via presynaptic receptors for adenosine but not ATP |
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Authors | |
Keywords | Adenosine Adenosine β, γ-methylene-5′-triphosphate Adenosine-5′-triphosphate Adrenergic neurotransmission Saphenous vein Purinergic receptors |
Issue Date | 1979 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar |
Citation | European Journal Of Pharmacology, 1979, v. 55 n. 4, p. 401-405 How to Cite? |
Abstract | The effects of adenosine, ATP and adenosine β, γ-methylene-5'-triphosphate (APPCP) were compared in the saphenous vein of the dog. Adenosine and ATP in concentrations which did not affect the response to exogenous noradrenaline, depressed that to nerve stimulation; this effect was antagonized by theophylline. APPCP increased tension in unstimulated veins and in those made to contract with noradrenaline and nerve stimulation. The results suggest that the inhibitory effect of ATP on adrenergic neurotransmission is due to its rapid breakdown to adenosine, which acts on prejunctional P1 purinoceptors. |
Persistent Identifier | http://hdl.handle.net/10722/170582 |
ISSN | 2023 Impact Factor: 4.2 2023 SCImago Journal Rankings: 1.055 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | De Mey, J | en_US |
dc.contributor.author | Burnstock, G | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:10:02Z | - |
dc.date.available | 2012-10-30T06:10:02Z | - |
dc.date.issued | 1979 | en_US |
dc.identifier.citation | European Journal Of Pharmacology, 1979, v. 55 n. 4, p. 401-405 | en_US |
dc.identifier.issn | 0014-2999 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170582 | - |
dc.description.abstract | The effects of adenosine, ATP and adenosine β, γ-methylene-5'-triphosphate (APPCP) were compared in the saphenous vein of the dog. Adenosine and ATP in concentrations which did not affect the response to exogenous noradrenaline, depressed that to nerve stimulation; this effect was antagonized by theophylline. APPCP increased tension in unstimulated veins and in those made to contract with noradrenaline and nerve stimulation. The results suggest that the inhibitory effect of ATP on adrenergic neurotransmission is due to its rapid breakdown to adenosine, which acts on prejunctional P1 purinoceptors. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar | en_US |
dc.relation.ispartof | European Journal of Pharmacology | en_US |
dc.subject | Adenosine | - |
dc.subject | Adenosine β, γ-methylene-5′-triphosphate | - |
dc.subject | Adenosine-5′-triphosphate | - |
dc.subject | Adrenergic neurotransmission | - |
dc.subject | Saphenous vein Purinergic receptors | - |
dc.subject.mesh | Adenosine - Physiology | en_US |
dc.subject.mesh | Adenosine Triphosphate - Analogs & Derivatives - Physiology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Blood Vessels - Metabolism | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Electric Stimulation | en_US |
dc.subject.mesh | Muscle Contraction | en_US |
dc.subject.mesh | Muscle, Smooth - Physiology | en_US |
dc.subject.mesh | Norepinephrine - Metabolism | en_US |
dc.subject.mesh | Receptors, Cell Surface - Physiology | en_US |
dc.subject.mesh | Saphenous Vein - Metabolism | en_US |
dc.title | Modulation of the evoked release of noradrenaline in canine saphenous vein via presynaptic receptors for adenosine but not ATP | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 223855 | - |
dc.identifier.scopus | eid_2-s2.0-0018392008 | en_US |
dc.identifier.volume | 55 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 401 | en_US |
dc.identifier.epage | 405 | en_US |
dc.identifier.isi | WOS:A1979GX84700008 | - |
dc.publisher.place | Netherlands | en_US |
dc.identifier.scopusauthorid | De Mey, J=7101918486 | en_US |
dc.identifier.scopusauthorid | Burnstock, G=36037094600 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0014-2999 | - |