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Article: Vascular reactivity of the isolated tibia of the dog

TitleVascular reactivity of the isolated tibia of the dog
Authors
Issue Date1979
PublisherAmerican Physiological Society. The Journal's web site is located at http://intl-ajpheart.physiology.org/
Citation
American Journal Of Physiology - Heart And Circulatory Physiology, 1979, v. 5 n. 6, p. H904-H908 How to Cite?
AbstractExperiments were performed to assess the responsiveness of vessels subserving bone tissue to nerve stimulation and to exogenously administered catecholamines and acetylcholine. Tibias of mongrel dogs were isolated and dissected free; the periosteum was left intact. The main nutrient artery was prepared and cannulated. Ring electrodes were placed around the artery. The preparation was perfused at constant flow with aerated (95% O2 - 5% CO2) Krebs-Ringer solution (37°C) by means of a roller pump. The perfusion pressure was continuously recorded. For each preparation, the flow rate was used at which the response to a standard dose of norepinephrine was the largest. Periarterial electrical stimulation caused frequency-dependent increases in perfusion pressure; because these responses were blocked by phentolamine, they must be due to activation of sympathetic nerves. Injections of norepinephrine caused dose-dependent increases in perfusion pressure that were abolished by phentolamine. Acetylcholine caused dose-dependent, atropine-sensitive decreased of the constrictions caused by norepinephrine infusions. These experiments demonstrate that the isolated perfused tibia of the dog is a satisfactory preparation to investigate the direct effects of sympathetic nerve stimulation and naturally occurring vasoactive amines on bone blood vessels.
Persistent Identifierhttp://hdl.handle.net/10722/170581
ISSN
2015 Impact Factor: 3.324
2015 SCImago Journal Rankings: 1.823

 

DC FieldValueLanguage
dc.contributor.authorDriessens, Men_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:01Z-
dc.date.available2012-10-30T06:10:01Z-
dc.date.issued1979en_US
dc.identifier.citationAmerican Journal Of Physiology - Heart And Circulatory Physiology, 1979, v. 5 n. 6, p. H904-H908en_US
dc.identifier.issn0363-6135en_US
dc.identifier.urihttp://hdl.handle.net/10722/170581-
dc.description.abstractExperiments were performed to assess the responsiveness of vessels subserving bone tissue to nerve stimulation and to exogenously administered catecholamines and acetylcholine. Tibias of mongrel dogs were isolated and dissected free; the periosteum was left intact. The main nutrient artery was prepared and cannulated. Ring electrodes were placed around the artery. The preparation was perfused at constant flow with aerated (95% O2 - 5% CO2) Krebs-Ringer solution (37°C) by means of a roller pump. The perfusion pressure was continuously recorded. For each preparation, the flow rate was used at which the response to a standard dose of norepinephrine was the largest. Periarterial electrical stimulation caused frequency-dependent increases in perfusion pressure; because these responses were blocked by phentolamine, they must be due to activation of sympathetic nerves. Injections of norepinephrine caused dose-dependent increases in perfusion pressure that were abolished by phentolamine. Acetylcholine caused dose-dependent, atropine-sensitive decreased of the constrictions caused by norepinephrine infusions. These experiments demonstrate that the isolated perfused tibia of the dog is a satisfactory preparation to investigate the direct effects of sympathetic nerve stimulation and naturally occurring vasoactive amines on bone blood vessels.en_US
dc.languageengen_US
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://intl-ajpheart.physiology.org/en_US
dc.relation.ispartofAmerican Journal of Physiology - Heart and Circulatory Physiologyen_US
dc.titleVascular reactivity of the isolated tibia of the dogen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0018390122en_US
dc.identifier.volume5en_US
dc.identifier.issue6en_US
dc.identifier.spageH904en_US
dc.identifier.epageH908en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridDriessens, M=7004361873en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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