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Article: Disposition of the pulmonary toxin, bleomycin

TitleDisposition of the pulmonary toxin, bleomycin
Authors
Issue Date1979
Citation
Drug Metabolism And Disposition, 1979, v. 7 n. 2, p. 90-93 How to Cite?
AbstractThe disposition of bleomycin in rats was investigated with the use of a 57Co-labeled bleomycin radioimmunoassay. Bleomycin (1 mg/kg,ip) reached a peak serum level of 0.70-1.0 μg/ml in 54 ± 4 min (mean ± SE) and was eliminated with a t 1/2 of 32 ± 1 min. The apparent volume of distribution in rats was 184 ± 11 ml/kg. No change in t 1/2 was observed when rats were pretreated with phenobarbital (1 mg/ml in drinking water for 4 days) or exposed to ozone (3 ppm, 24 hr). Probenecid (0.2 g/kg,ip) given 20 min prior to bleomycin administration increased the t 1/2 2-fold. The order of tissue distribution of 57Co-labeled bleomycin 2 hr after ip administration was: kidney ≥ liver > lungs > spleen > heart > thymus. The affinity of 57Co-labeled bleomycin for homogenates of lungs, liver, or kidney was equal.
Persistent Identifierhttp://hdl.handle.net/10722/170580
ISSN
2015 Impact Factor: 3.21
2015 SCImago Journal Rankings: 1.249
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTom, WMen_US
dc.contributor.authorMontgomery, MRen_US
dc.date.accessioned2012-10-30T06:10:01Z-
dc.date.available2012-10-30T06:10:01Z-
dc.date.issued1979en_US
dc.identifier.citationDrug Metabolism And Disposition, 1979, v. 7 n. 2, p. 90-93en_US
dc.identifier.issn0090-9556en_US
dc.identifier.urihttp://hdl.handle.net/10722/170580-
dc.description.abstractThe disposition of bleomycin in rats was investigated with the use of a 57Co-labeled bleomycin radioimmunoassay. Bleomycin (1 mg/kg,ip) reached a peak serum level of 0.70-1.0 μg/ml in 54 ± 4 min (mean ± SE) and was eliminated with a t 1/2 of 32 ± 1 min. The apparent volume of distribution in rats was 184 ± 11 ml/kg. No change in t 1/2 was observed when rats were pretreated with phenobarbital (1 mg/ml in drinking water for 4 days) or exposed to ozone (3 ppm, 24 hr). Probenecid (0.2 g/kg,ip) given 20 min prior to bleomycin administration increased the t 1/2 2-fold. The order of tissue distribution of 57Co-labeled bleomycin 2 hr after ip administration was: kidney ≥ liver > lungs > spleen > heart > thymus. The affinity of 57Co-labeled bleomycin for homogenates of lungs, liver, or kidney was equal.en_US
dc.languageengen_US
dc.relation.ispartofDrug Metabolism and Dispositionen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBleomycin - Immunology - Metabolismen_US
dc.subject.meshCobalt Radioisotopes - Diagnostic Useen_US
dc.subject.meshKineticsen_US
dc.subject.meshLigandsen_US
dc.subject.meshLung - Drug Effects - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshPhenobarbital - Pharmacologyen_US
dc.subject.meshProbenecid - Pharmacologyen_US
dc.subject.meshRadioimmunoassayen_US
dc.subject.meshRatsen_US
dc.subject.meshTissue Distributionen_US
dc.titleDisposition of the pulmonary toxin, bleomycinen_US
dc.typeArticleen_US
dc.identifier.emailTom, WM:wmtoma@hkucc.hku.hken_US
dc.identifier.authorityTom, WM=rp00237en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid89025-
dc.identifier.scopuseid_2-s2.0-0018386023en_US
dc.identifier.volume7en_US
dc.identifier.issue2en_US
dc.identifier.spage90en_US
dc.identifier.epage93en_US
dc.identifier.isiWOS:A1979GS61200006-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTom, WM=7003709519en_US
dc.identifier.scopusauthoridMontgomery, MR=24441141600en_US

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