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- Scopus: eid_2-s2.0-0018386023
- PMID: 89025
- WOS: WOS:A1979GS61200006
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Article: Disposition of the pulmonary toxin, bleomycin
Title | Disposition of the pulmonary toxin, bleomycin |
---|---|
Authors | |
Issue Date | 1979 |
Citation | Drug Metabolism And Disposition, 1979, v. 7 n. 2, p. 90-93 How to Cite? |
Abstract | The disposition of bleomycin in rats was investigated with the use of a 57Co-labeled bleomycin radioimmunoassay. Bleomycin (1 mg/kg,ip) reached a peak serum level of 0.70-1.0 μg/ml in 54 ± 4 min (mean ± SE) and was eliminated with a t 1/2 of 32 ± 1 min. The apparent volume of distribution in rats was 184 ± 11 ml/kg. No change in t 1/2 was observed when rats were pretreated with phenobarbital (1 mg/ml in drinking water for 4 days) or exposed to ozone (3 ppm, 24 hr). Probenecid (0.2 g/kg,ip) given 20 min prior to bleomycin administration increased the t 1/2 2-fold. The order of tissue distribution of 57Co-labeled bleomycin 2 hr after ip administration was: kidney ≥ liver > lungs > spleen > heart > thymus. The affinity of 57Co-labeled bleomycin for homogenates of lungs, liver, or kidney was equal. |
Persistent Identifier | http://hdl.handle.net/10722/170580 |
ISSN | 2023 Impact Factor: 4.4 2023 SCImago Journal Rankings: 0.941 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Tom, WM | en_US |
dc.contributor.author | Montgomery, MR | en_US |
dc.date.accessioned | 2012-10-30T06:10:01Z | - |
dc.date.available | 2012-10-30T06:10:01Z | - |
dc.date.issued | 1979 | en_US |
dc.identifier.citation | Drug Metabolism And Disposition, 1979, v. 7 n. 2, p. 90-93 | en_US |
dc.identifier.issn | 0090-9556 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170580 | - |
dc.description.abstract | The disposition of bleomycin in rats was investigated with the use of a 57Co-labeled bleomycin radioimmunoassay. Bleomycin (1 mg/kg,ip) reached a peak serum level of 0.70-1.0 μg/ml in 54 ± 4 min (mean ± SE) and was eliminated with a t 1/2 of 32 ± 1 min. The apparent volume of distribution in rats was 184 ± 11 ml/kg. No change in t 1/2 was observed when rats were pretreated with phenobarbital (1 mg/ml in drinking water for 4 days) or exposed to ozone (3 ppm, 24 hr). Probenecid (0.2 g/kg,ip) given 20 min prior to bleomycin administration increased the t 1/2 2-fold. The order of tissue distribution of 57Co-labeled bleomycin 2 hr after ip administration was: kidney ≥ liver > lungs > spleen > heart > thymus. The affinity of 57Co-labeled bleomycin for homogenates of lungs, liver, or kidney was equal. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Drug Metabolism and Disposition | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Bleomycin - Immunology - Metabolism | en_US |
dc.subject.mesh | Cobalt Radioisotopes - Diagnostic Use | en_US |
dc.subject.mesh | Kinetics | en_US |
dc.subject.mesh | Ligands | en_US |
dc.subject.mesh | Lung - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Phenobarbital - Pharmacology | en_US |
dc.subject.mesh | Probenecid - Pharmacology | en_US |
dc.subject.mesh | Radioimmunoassay | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Tissue Distribution | en_US |
dc.title | Disposition of the pulmonary toxin, bleomycin | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tom, WM:wmtoma@hkucc.hku.hk | en_US |
dc.identifier.authority | Tom, WM=rp00237 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 89025 | - |
dc.identifier.scopus | eid_2-s2.0-0018386023 | en_US |
dc.identifier.volume | 7 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 90 | en_US |
dc.identifier.epage | 93 | en_US |
dc.identifier.isi | WOS:A1979GS61200006 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Tom, WM=7003709519 | en_US |
dc.identifier.scopusauthorid | Montgomery, MR=24441141600 | en_US |
dc.identifier.issnl | 0090-9556 | - |