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Article: Inhibitory effects of catecholamines in isolated canine bronchial smooth muscle

TitleInhibitory effects of catecholamines in isolated canine bronchial smooth muscle
Authors
Issue Date1979
Citation
Journal Of Applied Physiology Respiratory Environmental And Exercise Physiology, 1979, v. 46 n. 4, p. 787-791 How to Cite?
AbstractExperiments were designed to investigate whether catecholamines affect cholinergic neurotransmission in the bronchial wall. Rings of canine bronchi were mounted for continuous isometric tension recording. Acetylcholine and electrical stimulation caused contractions. As the response to electrical stimulation was unaffected by hexamethonium, but inhibited by tetrodotoxin and atropine, it must be due to release of endogenous acetylcholine from postganglionic cholinergic nerves. Norepinephrine and isoproterenol inhibited the response to electrical stimulation significantly more than that to acetylcholine; propranolol abolished the inhibition in both cases. These findings suggest that in the canine bronchi catecholamines induce dilation during bronchoconstriction caused by increased cholinergic nerve activity, whereas they have relatively weak inhibitory effects on bronchial smooth muscle made to contract with exogenous acetylcholine. Propranolol augmented the contractile response to electrical stimulation, but not that to acetylcholine. Helical bronchial strips were incubated with [3H]norepinephrine and mounted for superfusion; the overflow of tritiated compounds in the superfusate was measured. Electrical stimulation augmented markedly the 3H efflux. These observations indicate that the electric impulses activate both cholinergic and adrenergic nerves in the bronchial wall, and that endogenously released norepinephrine can partially inhibit bronchoconstrictions caused by stimulation of the cholinergic nerves.
Persistent Identifierhttp://hdl.handle.net/10722/170577
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVermeire, PAen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:01Z-
dc.date.available2012-10-30T06:10:01Z-
dc.date.issued1979en_US
dc.identifier.citationJournal Of Applied Physiology Respiratory Environmental And Exercise Physiology, 1979, v. 46 n. 4, p. 787-791en_US
dc.identifier.issn0161-7567en_US
dc.identifier.urihttp://hdl.handle.net/10722/170577-
dc.description.abstractExperiments were designed to investigate whether catecholamines affect cholinergic neurotransmission in the bronchial wall. Rings of canine bronchi were mounted for continuous isometric tension recording. Acetylcholine and electrical stimulation caused contractions. As the response to electrical stimulation was unaffected by hexamethonium, but inhibited by tetrodotoxin and atropine, it must be due to release of endogenous acetylcholine from postganglionic cholinergic nerves. Norepinephrine and isoproterenol inhibited the response to electrical stimulation significantly more than that to acetylcholine; propranolol abolished the inhibition in both cases. These findings suggest that in the canine bronchi catecholamines induce dilation during bronchoconstriction caused by increased cholinergic nerve activity, whereas they have relatively weak inhibitory effects on bronchial smooth muscle made to contract with exogenous acetylcholine. Propranolol augmented the contractile response to electrical stimulation, but not that to acetylcholine. Helical bronchial strips were incubated with [3H]norepinephrine and mounted for superfusion; the overflow of tritiated compounds in the superfusate was measured. Electrical stimulation augmented markedly the 3H efflux. These observations indicate that the electric impulses activate both cholinergic and adrenergic nerves in the bronchial wall, and that endogenously released norepinephrine can partially inhibit bronchoconstrictions caused by stimulation of the cholinergic nerves.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Applied Physiology Respiratory Environmental and Exercise Physiologyen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBronchi - Physiologyen_US
dc.subject.meshDogsen_US
dc.subject.meshEpinephrine - Pharmacologyen_US
dc.subject.meshIsoproterenol - Pharmacologyen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth - Physiologyen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshPropranolol - Pharmacologyen_US
dc.titleInhibitory effects of catecholamines in isolated canine bronchial smooth muscleen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid457558-
dc.identifier.scopuseid_2-s2.0-0018375661en_US
dc.identifier.volume46en_US
dc.identifier.issue4en_US
dc.identifier.spage787en_US
dc.identifier.epage791en_US
dc.identifier.isiWOS:A1979GS97500025-
dc.identifier.scopusauthoridVermeire, PA=7005494192en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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