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Article: Norepinephrine metabolism in canine saphenous vein: Prevalence of glycol metabolites

TitleNorepinephrine metabolism in canine saphenous vein: Prevalence of glycol metabolites
Authors
Issue Date1978
PublisherAmerican Physiological Society. The Journal's web site is located at http://intl-ajpheart.physiology.org/
Citation
American Journal Of Physiology - Heart And Circulatory Physiology, 1978, v. 3 n. 3, p. H235-H243 How to Cite?
AbstractTo examine the disposition of [3H]norepinephrine ([3H]NE) in adrenergically innervated veins, helical strips of canine saphenous veins were incubated in Krebs-Ringer solution containing D,L[3H]NE (2 x 10-7 M) for 2 hr. [3H]NE and its metabolites were measured in extracts of veins and in superfusate (Krebs-Ringer) collected during basal conditions and during release of [3H]NE evoked by electrical stimulation (1-8 Hz), tyramine (5 x 10-6 x 10-4 M), or high concentrations of potassium (35-100 meq/liter). During basal conditions, the efflux from veins comprised mainly metabolites of [3H]NE, especially 3,4-dihydroxyphenylglycol (DOPEG) and 3-methoxy-4-hydroxyphenylglycol (MOPEG); this pattern was unchanged by cocaine treatment, and monoamine oxidase inhibition reduced the formation of DOPEG. During evoked release of NE, the major metabolites in the perfusate were DOPEG, MOPEG, and normetanephrine, and their proportions differed with the stimulus used: O-methylated metabolites in the perfusate always increased more than did the deaminated catechol compounds; DOPEG and MOPEG were released in greater amounts than the corresponding acids; and cocaine treatment caused a higher content of all metabolites except DOPEG. 3-Methoxy-4-hydroxymandelic acid was also formed by the vein but was retained in the tissue.
Persistent Identifierhttp://hdl.handle.net/10722/170566
ISSN
2015 Impact Factor: 3.324
2015 SCImago Journal Rankings: 1.823

 

DC FieldValueLanguage
dc.contributor.authorMuldoon, SMen_US
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorTyce, GMen_US
dc.date.accessioned2012-10-30T06:09:58Z-
dc.date.available2012-10-30T06:09:58Z-
dc.date.issued1978en_US
dc.identifier.citationAmerican Journal Of Physiology - Heart And Circulatory Physiology, 1978, v. 3 n. 3, p. H235-H243en_US
dc.identifier.issn0363-6135en_US
dc.identifier.urihttp://hdl.handle.net/10722/170566-
dc.description.abstractTo examine the disposition of [3H]norepinephrine ([3H]NE) in adrenergically innervated veins, helical strips of canine saphenous veins were incubated in Krebs-Ringer solution containing D,L[3H]NE (2 x 10-7 M) for 2 hr. [3H]NE and its metabolites were measured in extracts of veins and in superfusate (Krebs-Ringer) collected during basal conditions and during release of [3H]NE evoked by electrical stimulation (1-8 Hz), tyramine (5 x 10-6 x 10-4 M), or high concentrations of potassium (35-100 meq/liter). During basal conditions, the efflux from veins comprised mainly metabolites of [3H]NE, especially 3,4-dihydroxyphenylglycol (DOPEG) and 3-methoxy-4-hydroxyphenylglycol (MOPEG); this pattern was unchanged by cocaine treatment, and monoamine oxidase inhibition reduced the formation of DOPEG. During evoked release of NE, the major metabolites in the perfusate were DOPEG, MOPEG, and normetanephrine, and their proportions differed with the stimulus used: O-methylated metabolites in the perfusate always increased more than did the deaminated catechol compounds; DOPEG and MOPEG were released in greater amounts than the corresponding acids; and cocaine treatment caused a higher content of all metabolites except DOPEG. 3-Methoxy-4-hydroxymandelic acid was also formed by the vein but was retained in the tissue.en_US
dc.languageengen_US
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://intl-ajpheart.physiology.org/en_US
dc.relation.ispartofAmerican Journal of Physiology - Heart and Circulatory Physiologyen_US
dc.titleNorepinephrine metabolism in canine saphenous vein: Prevalence of glycol metabolitesen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0018238149en_US
dc.identifier.volume3en_US
dc.identifier.issue3en_US
dc.identifier.spageH235en_US
dc.identifier.epageH243en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMuldoon, SM=7006041150en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridTyce, GM=7004909546en_US

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