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- Publisher Website: 10.1161/01.RES.43.4.544
- Scopus: eid_2-s2.0-0018125446
- PMID: 688557
- WOS: WOS:A1978FS75600009
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Article: Increased renal vascular reactivity to angiotensin II but not to nerve stimulation or exogenous norepinephrine in renal hypertensive rats
Title | Increased renal vascular reactivity to angiotensin II but not to nerve stimulation or exogenous norepinephrine in renal hypertensive rats |
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Authors | |
Issue Date | 1978 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://circres.ahajournals.org |
Citation | Circulation Research, 1978, v. 43 n. 4, p. 544-552 How to Cite? |
Abstract | We isolated and perfused both the 'clipped' and 'contralateral' kidneys from Goldblatt renal hypertensive and sham-operated control rats, 1-104 days postoperatively. Responses to renal nerve stimulation were depressed in clipped kidneys from hypertensive rats (1 day postoperative), and these kidneys were supersensitive to exogenous norepinephrine (1-31 days) when compared with the contralateral organ of the same animal. Similar alterations were found between clipped and contralateral kidneys from sham-operated control rats. There was no difference in responses to renal nerve stimulation of norepinephrine between clipped kidneys from hypertensive and control rats, but clipped kidneys from hypertensive rats were supersensitive to angiotensin II (17 and 31 days). Comparison of contralateral kidneys from hypersensitive and control rats revealed no change in norepinephrine sensitivity or in responses to renal nerve stimulation, but there was a reduction in the slope of the dose-response curve to norepinephrine and of the maximal effect of the catecholamine (104 days) and a pronounced supersensitivity to angiotensin II (17-104 days) in the hypertensive rats. These results indicate that renal nerve function and norepinephrine sensitivity of the isolated renal vasculature are unchanged in renal hypertension, but clipping partially denervates the kidneys causing depressed nerve function and unilateral norepinephrine supersensitivity, unrelated to hypertension; the prolonged high pressure load on the contralateral kidney may impair the function of the vascular smooth muscle; and bilateral supersensitivity to angiotensin II is associated with hypertension but is not solely a consequence of the high pressure. |
Persistent Identifier | http://hdl.handle.net/10722/170558 |
ISSN | 2023 Impact Factor: 16.5 2023 SCImago Journal Rankings: 4.903 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Collis, MG | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:09:55Z | - |
dc.date.available | 2012-10-30T06:09:55Z | - |
dc.date.issued | 1978 | en_US |
dc.identifier.citation | Circulation Research, 1978, v. 43 n. 4, p. 544-552 | en_US |
dc.identifier.issn | 0009-7330 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170558 | - |
dc.description.abstract | We isolated and perfused both the 'clipped' and 'contralateral' kidneys from Goldblatt renal hypertensive and sham-operated control rats, 1-104 days postoperatively. Responses to renal nerve stimulation were depressed in clipped kidneys from hypertensive rats (1 day postoperative), and these kidneys were supersensitive to exogenous norepinephrine (1-31 days) when compared with the contralateral organ of the same animal. Similar alterations were found between clipped and contralateral kidneys from sham-operated control rats. There was no difference in responses to renal nerve stimulation of norepinephrine between clipped kidneys from hypertensive and control rats, but clipped kidneys from hypertensive rats were supersensitive to angiotensin II (17 and 31 days). Comparison of contralateral kidneys from hypersensitive and control rats revealed no change in norepinephrine sensitivity or in responses to renal nerve stimulation, but there was a reduction in the slope of the dose-response curve to norepinephrine and of the maximal effect of the catecholamine (104 days) and a pronounced supersensitivity to angiotensin II (17-104 days) in the hypertensive rats. These results indicate that renal nerve function and norepinephrine sensitivity of the isolated renal vasculature are unchanged in renal hypertension, but clipping partially denervates the kidneys causing depressed nerve function and unilateral norepinephrine supersensitivity, unrelated to hypertension; the prolonged high pressure load on the contralateral kidney may impair the function of the vascular smooth muscle; and bilateral supersensitivity to angiotensin II is associated with hypertension but is not solely a consequence of the high pressure. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://circres.ahajournals.org | en_US |
dc.relation.ispartof | Circulation Research | en_US |
dc.subject.mesh | Angiotensin Ii - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Dose-Response Relationship, Drug | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Hypertension, Renal - Physiopathology | en_US |
dc.subject.mesh | Hypertension, Renovascular - Physiopathology | en_US |
dc.subject.mesh | Kidney - Innervation | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Norepinephrine - Pharmacology | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Regional Blood Flow - Drug Effects | en_US |
dc.subject.mesh | Renal Artery - Drug Effects | en_US |
dc.title | Increased renal vascular reactivity to angiotensin II but not to nerve stimulation or exogenous norepinephrine in renal hypertensive rats | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1161/01.RES.43.4.544 | - |
dc.identifier.pmid | 688557 | - |
dc.identifier.scopus | eid_2-s2.0-0018125446 | en_US |
dc.identifier.volume | 43 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 544 | en_US |
dc.identifier.epage | 552 | en_US |
dc.identifier.isi | WOS:A1978FS75600009 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Collis, MG=7005797278 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0009-7330 | - |