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Article: Neuronal and vascular reactivity in isolated perfused kidneys during the development of spontaneous hypertension.

TitleNeuronal and vascular reactivity in isolated perfused kidneys during the development of spontaneous hypertension.
Authors
Issue Date1978
Citation
Clinical Science And Molecular Medicine. Supplement, 1978, v. 4, p. 233s-235s How to Cite?
Abstract1. Vascular reactivity was studied in Tyrode solution perfused kidneys from young (7 weeks) and mature (4-6 months) spontaneously hypertensive rats (SH rats). 2. The response to nerve stimulation was greater in the kidneys from young SH rats than in those from young control rats, both in control solution and after inhibition of the disposition of noradrenaline; both groups exhibited the same sensitivity to noradrenaline, angiotensin II and barium chloride. 3. The response to nerve stimulation was normal in kidneys from mature SH rats, but responses to noradrenaline, angiotensin II and barium chloride were greater than the control. 4. Cocaine potentiated the response to nerve stimulation more in the kidneys from mature SH rats than in those from the control rats. 5. The results suggest that renal sympathetic nerves release more noradrenaline than normal in the young SH rats, which could be an important factor in causing hypertension. 6. In the established phase of spontaneous hypertension the vascular reactivity to exogenous agonists is increased, probably as a consequence of high blood pressure; the more efficient neuronal uptake causes normalization of the response to sympathetic nerve stimulation.
Persistent Identifierhttp://hdl.handle.net/10722/170557
ISSN

 

DC FieldValueLanguage
dc.contributor.authorCollis, MGen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:09:55Z-
dc.date.available2012-10-30T06:09:55Z-
dc.date.issued1978en_US
dc.identifier.citationClinical Science And Molecular Medicine. Supplement, 1978, v. 4, p. 233s-235sen_US
dc.identifier.issn0144-4107en_US
dc.identifier.urihttp://hdl.handle.net/10722/170557-
dc.description.abstract1. Vascular reactivity was studied in Tyrode solution perfused kidneys from young (7 weeks) and mature (4-6 months) spontaneously hypertensive rats (SH rats). 2. The response to nerve stimulation was greater in the kidneys from young SH rats than in those from young control rats, both in control solution and after inhibition of the disposition of noradrenaline; both groups exhibited the same sensitivity to noradrenaline, angiotensin II and barium chloride. 3. The response to nerve stimulation was normal in kidneys from mature SH rats, but responses to noradrenaline, angiotensin II and barium chloride were greater than the control. 4. Cocaine potentiated the response to nerve stimulation more in the kidneys from mature SH rats than in those from the control rats. 5. The results suggest that renal sympathetic nerves release more noradrenaline than normal in the young SH rats, which could be an important factor in causing hypertension. 6. In the established phase of spontaneous hypertension the vascular reactivity to exogenous agonists is increased, probably as a consequence of high blood pressure; the more efficient neuronal uptake causes normalization of the response to sympathetic nerve stimulation.en_US
dc.languageengen_US
dc.relation.ispartofClinical science and molecular medicine. Supplementen_US
dc.subject.meshAngiotensin Ii - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBarium - Pharmacologyen_US
dc.subject.meshCocaine - Pharmacologyen_US
dc.subject.meshHypertension - Physiopathologyen_US
dc.subject.meshKidney - Blood Supply - Innervationen_US
dc.subject.meshMaleen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshVascular Resistance - Drug Effectsen_US
dc.titleNeuronal and vascular reactivity in isolated perfused kidneys during the development of spontaneous hypertension.en_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid282059-
dc.identifier.scopuseid_2-s2.0-0018109691en_US
dc.identifier.volume4en_US
dc.identifier.spage233sen_US
dc.identifier.epage235sen_US
dc.identifier.scopusauthoridCollis, MG=7005797278en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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