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Article: Differential effects of the isomers of tetramisole on adrenergic neurotransmission in cutaneous veins of dog

TitleDifferential effects of the isomers of tetramisole on adrenergic neurotransmission in cutaneous veins of dog
Authors
Issue Date1977
PublisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.org
Citation
Journal Of Pharmacology And Experimental Therapeutics, 1977, v. 200 n. 1, p. 127-140 How to Cite?
AbstractClinical observations indicate that dexamisole and levamisole, the isomers of tetramisole, cause mood elevation. Their effects on smooth muscle cells and adrenergic nerves were investigated in strips of dogs' saphenous veins. Dexamisole (2.5 X 10-6 to 4 X 10-5 M) augmented the contractile response to norepinephrine but depressed that to tyramine; cocaine inhibited the augmentation of the norepinephrine response. Levamisole (10-5 M) did not alter the response to norepinephrine, but augmented that to tyramine. At 1.6 X 10-4 M dexamisole, more than levamisole, depressed the responses to norepinephrine, tyramine and acetylcholine. Activation by K+ ions was not affected by the isomers. Preparations, incubated with 3H norepinephrine, were mounted for superfusion, tension recording and determination of 3H norepinephrine and metabolites in the superfusate. Dexamisole and levamisole augmented the 3H norepinephrine overflow during nerve stimulation; levamisole decreased the efflux of deaminated metabolites. During tyramine induced contractions, dexamisole depressed and levamisole augmented the efflux of 3H norepinephrine; they reduced the appearance of metabolites. The increases in 3H norepinephrine caused by the isomers during nerve stimulation were not seen after phenoxybenzamine. Dexamisole, more than levamisole, inhibited tissular uptake of 3H norepinephrine. Levamisole, more than dexamisole, inhibited monoamine oxidase activity in vein homogenates. These interferences with release and disposition of norepinephrine may be related to the antidepressant properties of the tetramisole isomers.
Persistent Identifierhttp://hdl.handle.net/10722/170527
ISSN
2015 Impact Factor: 3.76
2015 SCImago Journal Rankings: 1.847
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorVan Nueten, JMen_US
dc.contributor.authorVerbeuren, TJen_US
dc.contributor.authorLaduron, PMen_US
dc.date.accessioned2012-10-30T06:09:49Z-
dc.date.available2012-10-30T06:09:49Z-
dc.date.issued1977en_US
dc.identifier.citationJournal Of Pharmacology And Experimental Therapeutics, 1977, v. 200 n. 1, p. 127-140en_US
dc.identifier.issn0022-3565en_US
dc.identifier.urihttp://hdl.handle.net/10722/170527-
dc.description.abstractClinical observations indicate that dexamisole and levamisole, the isomers of tetramisole, cause mood elevation. Their effects on smooth muscle cells and adrenergic nerves were investigated in strips of dogs' saphenous veins. Dexamisole (2.5 X 10-6 to 4 X 10-5 M) augmented the contractile response to norepinephrine but depressed that to tyramine; cocaine inhibited the augmentation of the norepinephrine response. Levamisole (10-5 M) did not alter the response to norepinephrine, but augmented that to tyramine. At 1.6 X 10-4 M dexamisole, more than levamisole, depressed the responses to norepinephrine, tyramine and acetylcholine. Activation by K+ ions was not affected by the isomers. Preparations, incubated with 3H norepinephrine, were mounted for superfusion, tension recording and determination of 3H norepinephrine and metabolites in the superfusate. Dexamisole and levamisole augmented the 3H norepinephrine overflow during nerve stimulation; levamisole decreased the efflux of deaminated metabolites. During tyramine induced contractions, dexamisole depressed and levamisole augmented the efflux of 3H norepinephrine; they reduced the appearance of metabolites. The increases in 3H norepinephrine caused by the isomers during nerve stimulation were not seen after phenoxybenzamine. Dexamisole, more than levamisole, inhibited tissular uptake of 3H norepinephrine. Levamisole, more than dexamisole, inhibited monoamine oxidase activity in vein homogenates. These interferences with release and disposition of norepinephrine may be related to the antidepressant properties of the tetramisole isomers.en_US
dc.languageengen_US
dc.publisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.orgen_US
dc.relation.ispartofJournal of Pharmacology and Experimental Therapeuticsen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDogsen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshMonoamine Oxidase - Metabolismen_US
dc.subject.meshMuscle, Smooth - Drug Effects - Metabolismen_US
dc.subject.meshNorepinephrine - Metabolism - Pharmacologyen_US
dc.subject.meshPotassium - Pharmacologyen_US
dc.subject.meshSkin - Blood Supplyen_US
dc.subject.meshStereoisomerismen_US
dc.subject.meshSympathetic Nervous System - Drug Effects - Physiologyen_US
dc.subject.meshSynaptic Transmission - Drug Effectsen_US
dc.subject.meshTetramisole - Pharmacologyen_US
dc.subject.meshTyramine - Pharmacologyen_US
dc.subject.meshVeins - Innervation - Metabolismen_US
dc.titleDifferential effects of the isomers of tetramisole on adrenergic neurotransmission in cutaneous veins of dogen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid189006-
dc.identifier.scopuseid_2-s2.0-0017355555en_US
dc.identifier.volume200en_US
dc.identifier.issue1en_US
dc.identifier.spage127en_US
dc.identifier.epage140en_US
dc.identifier.isiWOS:A1977CU65500017-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridVan Nueten, JM=7005700327en_US
dc.identifier.scopusauthoridVerbeuren, TJ=7007006534en_US
dc.identifier.scopusauthoridLaduron, PM=7005611281en_US

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