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Article: Alpha adrenergic blocking properties of droperidol on isolated blood vessels of the dog

TitleAlpha adrenergic blocking properties of droperidol on isolated blood vessels of the dog
Authors
Issue Date1977
PublisherOxford University Press. The Journal's web site is located at http://bja.oxfordjournals.org/
Citation
British Journal Of Anaesthesia, 1977, v. 49 n. 3, p. 211-216 How to Cite?
AbstractConcentrations of droperidol which caused a shift to the right of the dose response curve to noradrenaline in the pulmonary artery and the saphenous vein of the dog did not affect myogenic activation by K +; they did not inhibit spontaneous activity of portal mesenteric veins. Droperidol inhibited the contractile response to nerve stimulation, but did not effect the evoked release of 3H noradrenaline. These experiments indicate that the vasodilator properties of smaller doses of droperidol are a result of its ability to block alpha adrenergic receptors.
Persistent Identifierhttp://hdl.handle.net/10722/170525
ISSN
2015 Impact Factor: 5.616
2015 SCImago Journal Rankings: 2.314
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMuldoon, SMen_US
dc.contributor.authorJanssens, WJen_US
dc.contributor.authorVerbeuren, TJen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:09:48Z-
dc.date.available2012-10-30T06:09:48Z-
dc.date.issued1977en_US
dc.identifier.citationBritish Journal Of Anaesthesia, 1977, v. 49 n. 3, p. 211-216en_US
dc.identifier.issn0007-0912en_US
dc.identifier.urihttp://hdl.handle.net/10722/170525-
dc.description.abstractConcentrations of droperidol which caused a shift to the right of the dose response curve to noradrenaline in the pulmonary artery and the saphenous vein of the dog did not affect myogenic activation by K +; they did not inhibit spontaneous activity of portal mesenteric veins. Droperidol inhibited the contractile response to nerve stimulation, but did not effect the evoked release of 3H noradrenaline. These experiments indicate that the vasodilator properties of smaller doses of droperidol are a result of its ability to block alpha adrenergic receptors.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://bja.oxfordjournals.org/en_US
dc.relation.ispartofBritish Journal of Anaesthesiaen_US
dc.subject.meshAdrenergic Alpha-Antagonistsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Vessels - Drug Effectsen_US
dc.subject.meshDogsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDroperidol - Pharmacologyen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshMesenteric Veins - Drug Effectsen_US
dc.subject.meshMuscle, Smooth - Drug Effectsen_US
dc.subject.meshNorepinephrine - Antagonists & Inhibitorsen_US
dc.subject.meshPotassium - Pharmacologyen_US
dc.subject.meshPulmonary Artery - Drug Effectsen_US
dc.subject.meshSaphenous Vein - Drug Effectsen_US
dc.titleAlpha adrenergic blocking properties of droperidol on isolated blood vessels of the dogen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/bja/49.3.211-
dc.identifier.pmid20911-
dc.identifier.scopuseid_2-s2.0-0017348884en_US
dc.identifier.volume49en_US
dc.identifier.issue3en_US
dc.identifier.spage211en_US
dc.identifier.epage216en_US
dc.identifier.isiWOS:A1977CY91600004-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridMuldoon, SM=7006041150en_US
dc.identifier.scopusauthoridJanssens, WJ=7006876881en_US
dc.identifier.scopusauthoridVerbeuren, TJ=7007006534en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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