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Article: Effect of cooling on beta-receptor mechanisms in isolated cutaneous veins of the dog

TitleEffect of cooling on beta-receptor mechanisms in isolated cutaneous veins of the dog
Authors
Issue Date1970
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ymvre
Citation
Microvascular Research, 1970, v. 2 n. 4, p. 454-461 How to Cite?
AbstractAlpha-adrenergic activation of cutaneous veins by nerve stimulation or norepinephrine has been shown to be facilitated by a decrease in temperature. In the present study, the effects of cooling on beta-adrenergic mechanisms in the cutaneous veins were investigated by recording changes in isometric tension in helical strips of saphenous veins. At 37°, low doses of isoproterenol had negligible relaxing effects on the preparations but reduced their reactivity to electric stimulation; in higher doses, isoproterenol caused contraction of the saphenous vein strips. Cooling the bath to 29° slightly decreased the basal tension of the preparations and markedly augmented the contracting effect of higher doses of isoproterenol. The depressing action of that drug on the reactivity to electric stimulation was markedly accentuated by cooling. In the presence of alpha-adrenolytic drugs, the relaxing action of norepinephrine was also facilitated by a decrease in temperature. Thus, in the cutaneous vein of the dog, both the venodilator (beta-adrenergic) and the venoconstrictor (alpha-adrenergic) actions of catecholamines are facilitated by a decrease in temperature. © 1970.
Persistent Identifierhttp://hdl.handle.net/10722/170493
ISSN
2015 Impact Factor: 2.3
2015 SCImago Journal Rankings: 1.030

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorShepherd, JTen_US
dc.date.accessioned2012-10-30T06:09:42Z-
dc.date.available2012-10-30T06:09:42Z-
dc.date.issued1970en_US
dc.identifier.citationMicrovascular Research, 1970, v. 2 n. 4, p. 454-461en_US
dc.identifier.issn0026-2862en_US
dc.identifier.urihttp://hdl.handle.net/10722/170493-
dc.description.abstractAlpha-adrenergic activation of cutaneous veins by nerve stimulation or norepinephrine has been shown to be facilitated by a decrease in temperature. In the present study, the effects of cooling on beta-adrenergic mechanisms in the cutaneous veins were investigated by recording changes in isometric tension in helical strips of saphenous veins. At 37°, low doses of isoproterenol had negligible relaxing effects on the preparations but reduced their reactivity to electric stimulation; in higher doses, isoproterenol caused contraction of the saphenous vein strips. Cooling the bath to 29° slightly decreased the basal tension of the preparations and markedly augmented the contracting effect of higher doses of isoproterenol. The depressing action of that drug on the reactivity to electric stimulation was markedly accentuated by cooling. In the presence of alpha-adrenolytic drugs, the relaxing action of norepinephrine was also facilitated by a decrease in temperature. Thus, in the cutaneous vein of the dog, both the venodilator (beta-adrenergic) and the venoconstrictor (alpha-adrenergic) actions of catecholamines are facilitated by a decrease in temperature. © 1970.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ymvreen_US
dc.relation.ispartofMicrovascular Researchen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCold Temperatureen_US
dc.subject.meshDogsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshIsoproterenol - Pharmacologyen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshPotassium Chloride - Pharmacologyen_US
dc.subject.meshReceptors, Adrenergicen_US
dc.subject.meshSaphenous Veinen_US
dc.subject.meshSerotonin - Pharmacologyen_US
dc.subject.meshSkin - Blood Supplyen_US
dc.subject.meshSodium Chloride - Pharmacologyen_US
dc.subject.meshVasomotor System - Physiologyen_US
dc.subject.meshVeins - Physiologyen_US
dc.titleEffect of cooling on beta-receptor mechanisms in isolated cutaneous veins of the dogen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid5523942-
dc.identifier.scopuseid_2-s2.0-0014854973en_US
dc.identifier.volume2en_US
dc.identifier.issue4en_US
dc.identifier.spage454en_US
dc.identifier.epage461en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridShepherd, JT=7401742522en_US

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