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Article: Challenges in the management of juvenile myelomonocytic leukaemia in Hong Kong over the past two decades

TitleChallenges in the management of juvenile myelomonocytic leukaemia in Hong Kong over the past two decades
Authors
KeywordsCase Series
Diagnosis
Juvenile Myelomonocytic Leukaemia
Treatment Outcome
Issue Date2012
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
Citation
Hong Kong Journal Of Paediatrics, 2012, v. 17 n. 3, p. 148-155 How to Cite?
AbstractJuvenile myelomonocytic leukaemia (JMML) is a rare myeloid malignancy of childhood. The diagnosis and treatment of this disease still remain as major clinical challenges. We aim to describe the clinical and pathological findings, as well as treatment outcomes of eight patients with JMML who received treatment in two hospitals in Hong Kong between 1993 and 2011. One patient with Noonan syndrome showed spontaneous resolution of disease. Four patients underwent allogeneic haematopoietic stem cell transplantation during 1996 to 2007. Three of them died of post-transplant relapse and refractory disease or transplant-related toxicity. The surviving transplanted patient had chronic graft-versus-host disease for 4 years, and eventually showed evidence of disease relapse with documented mixed chimerism. The other three patients who received supportive treatment were alive with persistent disease. Our future works should focus on optimising therapy and improving treatment outcome for JMML patients.
Persistent Identifierhttp://hdl.handle.net/10722/170470
ISSN
2014 Impact Factor: 0.133
2014 SCImago Journal Rankings: 0.126
References

 

DC FieldValueLanguage
dc.contributor.authorSurapolchai, Pen_US
dc.contributor.authorHa, SYen_US
dc.contributor.authorChiang, AKSen_US
dc.contributor.authorCheuk, DKLen_US
dc.contributor.authorLi, CHen_US
dc.contributor.authorSo, CCen_US
dc.contributor.authorWan, TSKen_US
dc.contributor.authorChan, GCFen_US
dc.date.accessioned2012-10-30T06:09:14Z-
dc.date.available2012-10-30T06:09:14Z-
dc.date.issued2012en_US
dc.identifier.citationHong Kong Journal Of Paediatrics, 2012, v. 17 n. 3, p. 148-155en_US
dc.identifier.issn1013-9923en_US
dc.identifier.urihttp://hdl.handle.net/10722/170470-
dc.description.abstractJuvenile myelomonocytic leukaemia (JMML) is a rare myeloid malignancy of childhood. The diagnosis and treatment of this disease still remain as major clinical challenges. We aim to describe the clinical and pathological findings, as well as treatment outcomes of eight patients with JMML who received treatment in two hospitals in Hong Kong between 1993 and 2011. One patient with Noonan syndrome showed spontaneous resolution of disease. Four patients underwent allogeneic haematopoietic stem cell transplantation during 1996 to 2007. Three of them died of post-transplant relapse and refractory disease or transplant-related toxicity. The surviving transplanted patient had chronic graft-versus-host disease for 4 years, and eventually showed evidence of disease relapse with documented mixed chimerism. The other three patients who received supportive treatment were alive with persistent disease. Our future works should focus on optimising therapy and improving treatment outcome for JMML patients.en_US
dc.languageengen_US
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.aspen_US
dc.relation.ispartofHong Kong Journal of Paediatricsen_US
dc.subjectCase Seriesen_US
dc.subjectDiagnosisen_US
dc.subjectJuvenile Myelomonocytic Leukaemiaen_US
dc.subjectTreatment Outcomeen_US
dc.titleChallenges in the management of juvenile myelomonocytic leukaemia in Hong Kong over the past two decadesen_US
dc.typeArticleen_US
dc.identifier.emailChiang, AKS:chiangak@hkucc.hku.hken_US
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_US
dc.identifier.authorityChiang, AKS=rp00403en_US
dc.identifier.authorityChan, GCF=rp00431en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.scopuseid_2-s2.0-84864392566en_US
dc.identifier.hkuros209851-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84864392566&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume17en_US
dc.identifier.issue3en_US
dc.identifier.spage148en_US
dc.identifier.epage155en_US
dc.publisher.placeHong Kongen_US
dc.identifier.scopusauthoridSurapolchai, P=36027047200en_US
dc.identifier.scopusauthoridHa, SY=7202501115en_US
dc.identifier.scopusauthoridChiang, AKS=7101623534en_US
dc.identifier.scopusauthoridCheuk, DKL=8705936100en_US
dc.identifier.scopusauthoridLi, CH=8354475100en_US
dc.identifier.scopusauthoridSo, CC=55323432800en_US
dc.identifier.scopusauthoridWan, TSK=55323335300en_US
dc.identifier.scopusauthoridChan, GCF=16160154400en_US

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