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Article: The Immunomodulatory and Anticancer Properties of Propolis

TitleThe Immunomodulatory and Anticancer Properties of Propolis
Authors
KeywordsAnticancer
Immune
Propolis
Issue Date2013
Citation
Clinical Reviews In Allergy And Immunology, 2013, v. 44 n. 3, p. 262-273 How to Cite?
AbstractPropolis, a waxy substance produced by the honeybee, has been adopted as a form of folk medicine since ancient times. It has a wide spectrum of alleged applications including potential anti-infection and anticancer effects. Many of the therapeutic effects can be attributed to its immunomodulatory functions. The composition of propolis can vary according to the geographic locations from where the bees obtained the ingredients. Two main immunopotent chemicals have been identified as caffeic acid phenethyl ester (CAPE) and artepillin C. Propolis, CAPE, and artepillin C have been shown to exert summative immunosuppressive function on T lymphocyte subsets but paradoxically activate macrophage function. On the other hand, they also have potential antitumor properties by different postulated mechanisms such as suppressing cancer cells proliferation via its anti-inflammatory effects; decreasing the cancer stem cell populations; blocking specific oncogene signaling pathways; exerting antiangiogenic effects; and modulating the tumor microenvironment. The good bioavailability by the oral route and good historical safety profile makes propolis an ideal adjuvant agent for future immunomodulatory or anticancer regimens. However, standardized quality controls and good design clinical trials are essential before either propolis or its active ingredients can be adopted routinely in our future therapeutic armamentarium. © 2012 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/170466
ISSN
2015 Impact Factor: 5.313
2015 SCImago Journal Rankings: 1.023
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, GCFen_US
dc.contributor.authorCheung, KWen_US
dc.contributor.authorSze, DMYen_US
dc.date.accessioned2012-10-30T06:09:11Z-
dc.date.available2012-10-30T06:09:11Z-
dc.date.issued2013en_US
dc.identifier.citationClinical Reviews In Allergy And Immunology, 2013, v. 44 n. 3, p. 262-273en_US
dc.identifier.issn1080-0549en_US
dc.identifier.urihttp://hdl.handle.net/10722/170466-
dc.description.abstractPropolis, a waxy substance produced by the honeybee, has been adopted as a form of folk medicine since ancient times. It has a wide spectrum of alleged applications including potential anti-infection and anticancer effects. Many of the therapeutic effects can be attributed to its immunomodulatory functions. The composition of propolis can vary according to the geographic locations from where the bees obtained the ingredients. Two main immunopotent chemicals have been identified as caffeic acid phenethyl ester (CAPE) and artepillin C. Propolis, CAPE, and artepillin C have been shown to exert summative immunosuppressive function on T lymphocyte subsets but paradoxically activate macrophage function. On the other hand, they also have potential antitumor properties by different postulated mechanisms such as suppressing cancer cells proliferation via its anti-inflammatory effects; decreasing the cancer stem cell populations; blocking specific oncogene signaling pathways; exerting antiangiogenic effects; and modulating the tumor microenvironment. The good bioavailability by the oral route and good historical safety profile makes propolis an ideal adjuvant agent for future immunomodulatory or anticancer regimens. However, standardized quality controls and good design clinical trials are essential before either propolis or its active ingredients can be adopted routinely in our future therapeutic armamentarium. © 2012 Springer Science+Business Media, LLC.en_US
dc.languageengen_US
dc.relation.ispartofClinical Reviews in Allergy and Immunologyen_US
dc.subjectAnticanceren_US
dc.subjectImmuneen_US
dc.subjectPropolisen_US
dc.titleThe Immunomodulatory and Anticancer Properties of Propolisen_US
dc.typeArticleen_US
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_US
dc.identifier.authorityChan, GCF=rp00431en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s12016-012-8322-2en_US
dc.identifier.pmid22707327-
dc.identifier.scopuseid_2-s2.0-84877876080en_US
dc.identifier.hkuros210624-
dc.identifier.spage262en_US
dc.identifier.epage273en_US
dc.identifier.isiWOS:000318647700006-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChan, GCF=16160154400en_US
dc.identifier.scopusauthoridCheung, KW=55250424600en_US
dc.identifier.scopusauthoridSze, DMY=55249540200en_US
dc.identifier.citeulike10826058-

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