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Article: Cutting edge: Decreased accumulation and regulatory function of CD4 +CD25 high T cells in human STAT5b deficiency

TitleCutting edge: Decreased accumulation and regulatory function of CD4 +CD25 high T cells in human STAT5b deficiency
Authors
Issue Date2006
PublisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org
Citation
Journal Of Immunology, 2006, v. 177 n. 5, p. 2770-2774 How to Cite?
AbstractWe show that STAT5b is important for the in vivo accumulation of CD4 +CD25 high T cells with regulatory cell function. A patient homozygous for a missense A630P STAT5b mutation displayed immune dysregulation and decreased numbers of CD4 +CD25 high T cells. STAT5b A630P/A630P CD4 +CD25 high T cells had low expression of forkhead box P3 and an impaired ability to suppress the proliferation of or to kill CD4 +CD25 - T cells. Expression of CD25, a component of the high-affinity IL-2R, was also reduced in response to IL-2 or after in vitro propagation. The impact of the STAT5b mutation was selective in that IL-2-mediated up-regulation of the common γ-chain cytokine receptor and perform, and activation-induced expressions of CD154 and IFN-γ were normal. These results indicate that STAT5b propagates an important IL-2-mediated signal for the in vivo accumulation of functional regulatory T cells. Copyright © 2006 by The American Association of Immunologists, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/170375
ISSN
2015 Impact Factor: 4.985
2015 SCImago Journal Rankings: 3.549
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCohen, ACen_US
dc.contributor.authorNadeau, KCen_US
dc.contributor.authorTu, Wen_US
dc.contributor.authorHwa, Ven_US
dc.contributor.authorDionis, Ken_US
dc.contributor.authorBezrodnik, Len_US
dc.contributor.authorTeper, Aen_US
dc.contributor.authorGaillard, Men_US
dc.contributor.authorHeinrich, Jen_US
dc.contributor.authorKrensky, AMen_US
dc.contributor.authorRosenfeld, RGen_US
dc.contributor.authorLewis, DBen_US
dc.date.accessioned2012-10-30T06:07:53Z-
dc.date.available2012-10-30T06:07:53Z-
dc.date.issued2006en_US
dc.identifier.citationJournal Of Immunology, 2006, v. 177 n. 5, p. 2770-2774en_US
dc.identifier.issn0022-1767en_US
dc.identifier.urihttp://hdl.handle.net/10722/170375-
dc.description.abstractWe show that STAT5b is important for the in vivo accumulation of CD4 +CD25 high T cells with regulatory cell function. A patient homozygous for a missense A630P STAT5b mutation displayed immune dysregulation and decreased numbers of CD4 +CD25 high T cells. STAT5b A630P/A630P CD4 +CD25 high T cells had low expression of forkhead box P3 and an impaired ability to suppress the proliferation of or to kill CD4 +CD25 - T cells. Expression of CD25, a component of the high-affinity IL-2R, was also reduced in response to IL-2 or after in vitro propagation. The impact of the STAT5b mutation was selective in that IL-2-mediated up-regulation of the common γ-chain cytokine receptor and perform, and activation-induced expressions of CD154 and IFN-γ were normal. These results indicate that STAT5b propagates an important IL-2-mediated signal for the in vivo accumulation of functional regulatory T cells. Copyright © 2006 by The American Association of Immunologists, Inc.en_US
dc.languageengen_US
dc.publisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.orgen_US
dc.relation.ispartofJournal of Immunologyen_US
dc.rightsThis is an author-produced version of a manuscript accepted for publication in The Journal of Immunology (The JI). The American Association of Immunologists, Inc. (The AAI), publisher of The JI, holds the copyright to this manuscript. This manuscript has not yet been copyedited or subjected to editorial proofreading by The JI; hence, it may differ from the final version published in The JI (online and in print). The AAI (The JI) is not liable for errors or omissions in this author-produced version of the manuscript or in any version derived from it by the National Institutes of Health or any other third party. The final, citable version of record can be found at www.jimmunol.org-
dc.subject.meshAdulten_US
dc.subject.meshAlanine - Genetics - Metabolismen_US
dc.subject.meshCd4-Positive T-Lymphocytes - Cytology - Immunology - Metabolismen_US
dc.subject.meshCell Proliferationen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshForkhead Transcription Factors - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshLymphocyte Activation - Immunologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMutation - Geneticsen_US
dc.subject.meshReceptors, Interleukin-2 - Metabolismen_US
dc.subject.meshStat5 Transcription Factor - Deficiency - Genetics - Metabolismen_US
dc.titleCutting edge: Decreased accumulation and regulatory function of CD4 +CD25 high T cells in human STAT5b deficiencyen_US
dc.typeArticleen_US
dc.identifier.emailTu, W:wwtu@hkucc.hku.hken_US
dc.identifier.authorityTu, W=rp00416en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.4049/jimmunol.177.5.2770-
dc.identifier.pmid16920911-
dc.identifier.scopuseid_2-s2.0-33747775187en_US
dc.identifier.hkuros179377-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33747775187&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume177en_US
dc.identifier.issue5en_US
dc.identifier.spage2770en_US
dc.identifier.epage2774en_US
dc.identifier.isiWOS:000240002800007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCohen, AC=36243086800en_US
dc.identifier.scopusauthoridNadeau, KC=35305427400en_US
dc.identifier.scopusauthoridTu, W=7006479236en_US
dc.identifier.scopusauthoridHwa, V=6603892234en_US
dc.identifier.scopusauthoridDionis, K=14123041200en_US
dc.identifier.scopusauthoridBezrodnik, L=6505819548en_US
dc.identifier.scopusauthoridTeper, A=6603660317en_US
dc.identifier.scopusauthoridGaillard, M=7101778245en_US
dc.identifier.scopusauthoridHeinrich, J=7201505277en_US
dc.identifier.scopusauthoridKrensky, AM=7007153789en_US
dc.identifier.scopusauthoridRosenfeld, RG=36043783200en_US
dc.identifier.scopusauthoridLewis, DB=7404750928en_US

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