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Article: Antiviral CD8 T cells in the control of primary human cytomegalovirus infection in early childhood

TitleAntiviral CD8 T cells in the control of primary human cytomegalovirus infection in early childhood
Authors
Issue Date2004
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 2004, v. 189 n. 9, p. 1619-1627 How to Cite?
AbstractHuman cytomegalovirus (CMV) establishes persistent infection, with control of replication thought to be mediated by CMV-specific CD8 T cells. Primary CMV infection commonly affects young children and causes prolonged viral shedding in saliva and urine. We investigated whether this virus-host interaction pattern reflects a developmental deficiency of antiviral CD8 T cell-mediated immunity during childhood. CMV-specific CD8 T cell responses in asymptomatic children with active infection were not different from adults with recent or long-term infection in frequency and functional analyses. High urine CMV concentrations were detected, despite these CMV-specific CD8 T cell responses. We conclude that delayed resolution of primary CMV infection in young children is not caused by a deficient CMV-specific CD8 T cell response. Because these healthy children continue to have local CMV replication, we suggest that CD8 T cells may function primarily to prevent symptomatic, disseminated disease.
Persistent Identifierhttp://hdl.handle.net/10722/170347
ISSN
2015 Impact Factor: 6.344
2015 SCImago Journal Rankings: 4.000
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, SFen_US
dc.contributor.authorTu, WWen_US
dc.contributor.authorSharp, MAen_US
dc.contributor.authorTongson, ECen_US
dc.contributor.authorHe, XSen_US
dc.contributor.authorGreenberg, HBen_US
dc.contributor.authorHolmes, THen_US
dc.contributor.authorWang, Zen_US
dc.contributor.authorKemble, Gen_US
dc.contributor.authorManganello, AMen_US
dc.contributor.authorAdler, SPen_US
dc.contributor.authorDekker, CLen_US
dc.contributor.authorLewis, DBen_US
dc.contributor.authorArvin, AMen_US
dc.date.accessioned2012-10-30T06:07:43Z-
dc.date.available2012-10-30T06:07:43Z-
dc.date.issued2004en_US
dc.identifier.citationJournal Of Infectious Diseases, 2004, v. 189 n. 9, p. 1619-1627en_US
dc.identifier.issn0022-1899en_US
dc.identifier.urihttp://hdl.handle.net/10722/170347-
dc.description.abstractHuman cytomegalovirus (CMV) establishes persistent infection, with control of replication thought to be mediated by CMV-specific CD8 T cells. Primary CMV infection commonly affects young children and causes prolonged viral shedding in saliva and urine. We investigated whether this virus-host interaction pattern reflects a developmental deficiency of antiviral CD8 T cell-mediated immunity during childhood. CMV-specific CD8 T cell responses in asymptomatic children with active infection were not different from adults with recent or long-term infection in frequency and functional analyses. High urine CMV concentrations were detected, despite these CMV-specific CD8 T cell responses. We conclude that delayed resolution of primary CMV infection in young children is not caused by a deficient CMV-specific CD8 T cell response. Because these healthy children continue to have local CMV replication, we suggest that CD8 T cells may function primarily to prevent symptomatic, disseminated disease.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.orgen_US
dc.relation.ispartofJournal of Infectious Diseasesen_US
dc.subject.meshAdulten_US
dc.subject.meshAging - Immunologyen_US
dc.subject.meshCd8-Positive T-Lymphocytes - Immunology - Pathologyen_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCytomegalovirus - Immunology - Isolation & Purificationen_US
dc.subject.meshCytomegalovirus Infections - Immunology - Virologyen_US
dc.subject.meshFlow Cytometryen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshInterferon-Gamma - Biosynthesisen_US
dc.subject.meshLymphocyte Activationen_US
dc.subject.meshUrine - Virologyen_US
dc.titleAntiviral CD8 T cells in the control of primary human cytomegalovirus infection in early childhooden_US
dc.typeArticleen_US
dc.identifier.emailTu, WW:wwtu@hkucc.hku.hken_US
dc.identifier.authorityTu, WW=rp00416en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1086/383249en_US
dc.identifier.pmid15116298-
dc.identifier.scopuseid_2-s2.0-2442580881en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2442580881&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume189en_US
dc.identifier.issue9en_US
dc.identifier.spage1619en_US
dc.identifier.epage1627en_US
dc.identifier.isiWOS:000220951300010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChen, SF=37040243500en_US
dc.identifier.scopusauthoridTu, WW=7006479236en_US
dc.identifier.scopusauthoridSharp, MA=7102701548en_US
dc.identifier.scopusauthoridTongson, EC=6507182137en_US
dc.identifier.scopusauthoridHe, XS=36061249700en_US
dc.identifier.scopusauthoridGreenberg, HB=7201404942en_US
dc.identifier.scopusauthoridHolmes, TH=35857851000en_US
dc.identifier.scopusauthoridWang, Z=8548618300en_US
dc.identifier.scopusauthoridKemble, G=35474594000en_US
dc.identifier.scopusauthoridManganello, AM=6507260764en_US
dc.identifier.scopusauthoridAdler, SP=7202093446en_US
dc.identifier.scopusauthoridDekker, CL=7005790077en_US
dc.identifier.scopusauthoridLewis, DB=7404750928en_US
dc.identifier.scopusauthoridArvin, AM=26425414800en_US

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