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Article: The effect of platyspondyly and pubertal growth spurt on the stature of patients with β-thalassaemia major

TitleThe effect of platyspondyly and pubertal growth spurt on the stature of patients with β-thalassaemia major
Authors
Issue Date1998
PublisherZhonghua Yixuehui. The Journal's web site is located at http://www.cmj.org/
Citation
Chinese Medical Journal, 1998, v. 111 n. 8, p. 731-735 How to Cite?
AbstractObjective To study the effect of the body proportion and pubertal growth spurt on the stature of children with β-thalassaemia major. Methods The height, sitting height, upper to lower segment (U : L) ratio and pubertal development were determined in 71 Chinese children (38 girls and 33 boys) with β-thalassaemia. The growth patterns of 20 patients with complete growth data between 3 years and final height, were analyzed according to whether they underwent a pubertal growth spurt or not. Results 27% of the boys and 32% of the girls had a height below the 3rd percentile. About 60% of all the children had a U : L ratio below the 10th percentile for age. Abnormal body proportion was found in patients with or without growth retardation. 34% of the 41 children over the age of 14 years underwent spontaneous puberty. In 28 patients over the age of 16 years, a growth spurt was observed in 46% of the children during spontaneous or induced puberty. The retrospective analysis showed that the height deviation from the mean in adulthood was significantly higher in patients without pubertal growth acceleration than in those with a growth spurt (x̄= -11.8 cm, s = 7.6 cm vs x̄= -4.4cm, s= 4.4cm; P= 0.02). Conclusions An abnormal U:L ratio was commonly observed in patients with β-thalassaemia major and may be one factor contributing to the short stature of these patients. Abnormal puberty was present in a significant proportion of children and the lack of a pubertal growth spurt was found to be detrimental to adult height.
Persistent Identifierhttp://hdl.handle.net/10722/170346
ISSN
2015 Impact Factor: 0.957
2015 SCImago Journal Rankings: 0.428
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLow, CKen_HK
dc.contributor.authorKwan, YWen_HK
dc.contributor.authorCheung, PTen_HK
dc.contributor.authorLi, MCen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorKarlberg, Jen_HK
dc.date.accessioned2012-10-30T06:07:40Z-
dc.date.available2012-10-30T06:07:40Z-
dc.date.issued1998en_HK
dc.identifier.citationChinese Medical Journal, 1998, v. 111 n. 8, p. 731-735en_HK
dc.identifier.issn0366-6999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/170346-
dc.description.abstractObjective To study the effect of the body proportion and pubertal growth spurt on the stature of children with β-thalassaemia major. Methods The height, sitting height, upper to lower segment (U : L) ratio and pubertal development were determined in 71 Chinese children (38 girls and 33 boys) with β-thalassaemia. The growth patterns of 20 patients with complete growth data between 3 years and final height, were analyzed according to whether they underwent a pubertal growth spurt or not. Results 27% of the boys and 32% of the girls had a height below the 3rd percentile. About 60% of all the children had a U : L ratio below the 10th percentile for age. Abnormal body proportion was found in patients with or without growth retardation. 34% of the 41 children over the age of 14 years underwent spontaneous puberty. In 28 patients over the age of 16 years, a growth spurt was observed in 46% of the children during spontaneous or induced puberty. The retrospective analysis showed that the height deviation from the mean in adulthood was significantly higher in patients without pubertal growth acceleration than in those with a growth spurt (x̄= -11.8 cm, s = 7.6 cm vs x̄= -4.4cm, s= 4.4cm; P= 0.02). Conclusions An abnormal U:L ratio was commonly observed in patients with β-thalassaemia major and may be one factor contributing to the short stature of these patients. Abnormal puberty was present in a significant proportion of children and the lack of a pubertal growth spurt was found to be detrimental to adult height.en_HK
dc.languageengen_US
dc.publisherZhonghua Yixuehui. The Journal's web site is located at http://www.cmj.org/en_HK
dc.relation.ispartofChinese Medical Journalen_HK
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshBody Heighten_US
dc.subject.meshChilden_US
dc.subject.meshChild Developmenten_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPuberty, Delayeden_US
dc.subject.meshBeta-Thalassemia - Physiopathologyen_US
dc.titleThe effect of platyspondyly and pubertal growth spurt on the stature of patients with β-thalassaemia majoren_HK
dc.typeArticleen_HK
dc.identifier.emailLow, CK: lcklow@hkucc.hku.hken_HK
dc.identifier.emailCheung, PT: ptcheung@hku.hken_HK
dc.identifier.emailLau, YL: lauylung@hku.hken_HK
dc.identifier.emailKarlberg, J: jpekarl@hkucc.hku.hken_HK
dc.identifier.authorityLow, CK=rp00337en_HK
dc.identifier.authorityCheung, PT=rp00351en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.identifier.authorityKarlberg, J=rp00400en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid11245030en_HK
dc.identifier.scopuseid_2-s2.0-2442498690en_HK
dc.identifier.hkuros33676-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2442498690&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume111en_HK
dc.identifier.issue8en_HK
dc.identifier.spage731en_HK
dc.identifier.epage735en_HK
dc.identifier.isiWOS:000075504700015-
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridLow, CK=7007049461en_HK
dc.identifier.scopusauthoridKwan, YW=35824631000en_HK
dc.identifier.scopusauthoridCheung, PT=7202595465en_HK
dc.identifier.scopusauthoridLi, MC=26642883500en_HK
dc.identifier.scopusauthoridHa, SY=17338231600en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridKarlberg, J=7005218406en_HK

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