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Article: Persistent and Selective Deficiency of CD4+ T Cell Immunity to Cytomegalovirus in Immunocompetent Young Children

TitlePersistent and Selective Deficiency of CD4+ T Cell Immunity to Cytomegalovirus in Immunocompetent Young Children
Authors
Issue Date2004
PublisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org
Citation
Journal Of Immunology, 2004, v. 172 n. 5, p. 3260-3267 How to Cite?
AbstractHealthy young children who acquire CMV have prolonged viral shedding into the urine and saliva, but whether this is attributable to limitations in viral-specific immune responses has not been explored. In this study, we found that otherwise immunocompetent young children after recent primary CMV infection accumulated markedly fewer CMV-specific CD4+ T cells that produced IFN-γ than did adults. These differences in CD4+ T cell function persisted for more than 1 year after viral acquisition, and did not apply to CMV-specific IFN-γ production by CD8+ T cells. The IFN-γ-producing CD4+ T cells of children or adults that were reactive with CMV Ags were mainly the CCR7low cell subset of memory (CD45R0highCD45RAlow) cells. The decreased IFN-γ response to CMV in children was selective, because their CCR7 low memory CD4+ T cells and those of adults produced similar levels of this cytokine after stimulation with staphylococcal enterotoxin B superantigen. CD4+ T cells from children also had reduced CMV-specific IL-2 and CD154 (CD40 ligand) expression, suggesting an early blockade in the differentiation of viral-specific CD4+ T cells. Following CMV acquisition, children, but not adults, persistently shed virus in urine, and this was observable for at least 29 mo postinfection. Thus, CD4+ T cell-mediated immunity to CMV in humans is generated in an age-dependent manner, and may have a substantial role in controlling renal viral replication and urinary shedding.
Persistent Identifierhttp://hdl.handle.net/10722/170337
ISSN
2015 Impact Factor: 4.985
2015 SCImago Journal Rankings: 3.549
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTu, Wen_US
dc.contributor.authorChen, Sen_US
dc.contributor.authorSharp, Men_US
dc.contributor.authorDekker, Cen_US
dc.contributor.authorManganello, AMen_US
dc.contributor.authorTongson, ECen_US
dc.contributor.authorMaecker, HTen_US
dc.contributor.authorHolmes, THen_US
dc.contributor.authorWang, Zen_US
dc.contributor.authorKemble, Gen_US
dc.contributor.authorAdler, Sen_US
dc.contributor.authorArvin, Aen_US
dc.contributor.authorLewis, DBen_US
dc.date.accessioned2012-10-30T06:07:36Z-
dc.date.available2012-10-30T06:07:36Z-
dc.date.issued2004en_US
dc.identifier.citationJournal Of Immunology, 2004, v. 172 n. 5, p. 3260-3267en_US
dc.identifier.issn0022-1767en_US
dc.identifier.urihttp://hdl.handle.net/10722/170337-
dc.description.abstractHealthy young children who acquire CMV have prolonged viral shedding into the urine and saliva, but whether this is attributable to limitations in viral-specific immune responses has not been explored. In this study, we found that otherwise immunocompetent young children after recent primary CMV infection accumulated markedly fewer CMV-specific CD4+ T cells that produced IFN-γ than did adults. These differences in CD4+ T cell function persisted for more than 1 year after viral acquisition, and did not apply to CMV-specific IFN-γ production by CD8+ T cells. The IFN-γ-producing CD4+ T cells of children or adults that were reactive with CMV Ags were mainly the CCR7low cell subset of memory (CD45R0highCD45RAlow) cells. The decreased IFN-γ response to CMV in children was selective, because their CCR7 low memory CD4+ T cells and those of adults produced similar levels of this cytokine after stimulation with staphylococcal enterotoxin B superantigen. CD4+ T cells from children also had reduced CMV-specific IL-2 and CD154 (CD40 ligand) expression, suggesting an early blockade in the differentiation of viral-specific CD4+ T cells. Following CMV acquisition, children, but not adults, persistently shed virus in urine, and this was observable for at least 29 mo postinfection. Thus, CD4+ T cell-mediated immunity to CMV in humans is generated in an age-dependent manner, and may have a substantial role in controlling renal viral replication and urinary shedding.en_US
dc.languageengen_US
dc.publisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.orgen_US
dc.relation.ispartofJournal of Immunologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshCd4-Positive T-Lymphocytes - Immunology - Metabolism - Virologyen_US
dc.subject.meshCd40 Ligand - Biosynthesisen_US
dc.subject.meshCd8-Positive T-Lymphocytes - Immunology - Virologyen_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCytomegalovirus - Immunologyen_US
dc.subject.meshCytomegalovirus Infections - Immunology - Virologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunity, Cellularen_US
dc.subject.meshImmunologic Memoryen_US
dc.subject.meshInfanten_US
dc.subject.meshInterferon-Gamma - Biosynthesisen_US
dc.subject.meshInterleukin-2 - Antagonists & Inhibitors - Biosynthesisen_US
dc.subject.meshLymphocyte Counten_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshReceptors, Ccr7en_US
dc.subject.meshReceptors, Chemokine - Biosynthesisen_US
dc.subject.meshT-Lymphocyte Subsets - Immunology - Metabolism - Virologyen_US
dc.subject.meshTh1 Cells - Immunology - Metabolism - Virologyen_US
dc.subject.meshVirus Shedding - Immunologyen_US
dc.titlePersistent and Selective Deficiency of CD4+ T Cell Immunity to Cytomegalovirus in Immunocompetent Young Childrenen_US
dc.typeArticleen_US
dc.identifier.emailTu, W:wwtu@hkucc.hku.hken_US
dc.identifier.authorityTu, W=rp00416en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.4049/jimmunol.172.5.3260-
dc.identifier.pmid14978134-
dc.identifier.scopuseid_2-s2.0-10744232580en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-10744232580&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume172en_US
dc.identifier.issue5en_US
dc.identifier.spage3260en_US
dc.identifier.epage3267en_US
dc.identifier.isiWOS:000189186000069-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTu, W=7006479236en_US
dc.identifier.scopusauthoridChen, S=37040243500en_US
dc.identifier.scopusauthoridSharp, M=7102701548en_US
dc.identifier.scopusauthoridDekker, C=7005790103en_US
dc.identifier.scopusauthoridManganello, AM=6507260764en_US
dc.identifier.scopusauthoridTongson, EC=6507182137en_US
dc.identifier.scopusauthoridMaecker, HT=7003967087en_US
dc.identifier.scopusauthoridHolmes, TH=35857851000en_US
dc.identifier.scopusauthoridWang, Z=8548618300en_US
dc.identifier.scopusauthoridKemble, G=35474594000en_US
dc.identifier.scopusauthoridAdler, S=7202093446en_US
dc.identifier.scopusauthoridArvin, A=26425414800en_US
dc.identifier.scopusauthoridLewis, DB=7404750928en_US

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