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Article: Bronchoalveolar Lavage in Ventilated Newborn Infants: Safety and Tumor Necrosis Factor-α Activity

TitleBronchoalveolar Lavage in Ventilated Newborn Infants: Safety and Tumor Necrosis Factor-α Activity
Authors
Issue Date1997
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jp
Citation
Journal Of Perinatology, 1997, v. 17 n. 5, p. 360-365 How to Cite?
AbstractObjective: To investigate the safety of bronchoalveolar lavage (BAL) in sick ventilated preterm and term newborn infants. Study Design: We studied 32 preterm and term newborn infants on mechanical ventilation during the first week of life. BAL was done through blind wedging of a suction catheter into the right lower lobe bronchus, and lavages were tested for albumin content and tumor necrosis factor-α (TNF-α) activity. Safety measures included cranial ultrasounds, chest radiographs, arterial pH and blood gas monitoring, and checking ventilatory settings before and up to 24 hours after the procedure and heart rate, oxygen saturation level and arterial blood pressure before, during and within 10 minutes after the procedure. Results: Heart rate dropped an average of 15% (p < 0.001), oxygen saturation decreased by 4% (p = 0.001), and systolic blood pressure increased by 19% (p < 0.001) during BAL, but these measures returned to baseline on completion of the procedure and were not outside of a physiologically accepted range. BAL did not result in neonatal morbidity or mortality. Blood pressure perturbations were of a lesser magnitude in infants with a birth weight <1000 gm than in those >1000 gm. The lavage fluid contained albumin, and TNF-α titers were generally low except in two very preterm infants with extensive intracranial hemorrhages and one preterm infant with sepsis from chorioamnionitis. Conclusion: BAL can be safely performed in intubated preterm and term infants, and the lavage samples are useful for cytokine assays.
Persistent Identifierhttp://hdl.handle.net/10722/170287
ISSN
2015 Impact Factor: 2.087
2015 SCImago Journal Rankings: 1.148
References

 

DC FieldValueLanguage
dc.contributor.authorBelai, YZen_US
dc.contributor.authorFindlay, RDen_US
dc.contributor.authorLau, ASen_US
dc.contributor.authorWalther, FJen_US
dc.date.accessioned2012-10-30T06:07:14Z-
dc.date.available2012-10-30T06:07:14Z-
dc.date.issued1997en_US
dc.identifier.citationJournal Of Perinatology, 1997, v. 17 n. 5, p. 360-365en_US
dc.identifier.issn0743-8346en_US
dc.identifier.urihttp://hdl.handle.net/10722/170287-
dc.description.abstractObjective: To investigate the safety of bronchoalveolar lavage (BAL) in sick ventilated preterm and term newborn infants. Study Design: We studied 32 preterm and term newborn infants on mechanical ventilation during the first week of life. BAL was done through blind wedging of a suction catheter into the right lower lobe bronchus, and lavages were tested for albumin content and tumor necrosis factor-α (TNF-α) activity. Safety measures included cranial ultrasounds, chest radiographs, arterial pH and blood gas monitoring, and checking ventilatory settings before and up to 24 hours after the procedure and heart rate, oxygen saturation level and arterial blood pressure before, during and within 10 minutes after the procedure. Results: Heart rate dropped an average of 15% (p < 0.001), oxygen saturation decreased by 4% (p = 0.001), and systolic blood pressure increased by 19% (p < 0.001) during BAL, but these measures returned to baseline on completion of the procedure and were not outside of a physiologically accepted range. BAL did not result in neonatal morbidity or mortality. Blood pressure perturbations were of a lesser magnitude in infants with a birth weight <1000 gm than in those >1000 gm. The lavage fluid contained albumin, and TNF-α titers were generally low except in two very preterm infants with extensive intracranial hemorrhages and one preterm infant with sepsis from chorioamnionitis. Conclusion: BAL can be safely performed in intubated preterm and term infants, and the lavage samples are useful for cytokine assays.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jpen_US
dc.relation.ispartofJournal of Perinatologyen_US
dc.titleBronchoalveolar Lavage in Ventilated Newborn Infants: Safety and Tumor Necrosis Factor-α Activityen_US
dc.typeArticleen_US
dc.identifier.emailLau, AS:asylau@hku.hken_US
dc.identifier.authorityLau, AS=rp00474en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0031231502en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031231502&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume17en_US
dc.identifier.issue5en_US
dc.identifier.spage360en_US
dc.identifier.epage365en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridBelai, YZ=6602315819en_US
dc.identifier.scopusauthoridFindlay, RD=7006759831en_US
dc.identifier.scopusauthoridLau, AS=7202626202en_US
dc.identifier.scopusauthoridWalther, FJ=7103100458en_US

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