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Article: Human cytomegalovirus matrix protein PP150 is efficiently presented as one of target antigens for cytotoxic T lymphocyte recognition

TitleHuman cytomegalovirus matrix protein PP150 is efficiently presented as one of target antigens for cytotoxic T lymphocyte recognition
Authors
Issue Date1997
PublisherChinese Medical Association. The Journal's web site is located at http://www.cmj.org/
Citation
Chinese Medical Journal, 1997, v. 110 n. 5, p. 397-400 How to Cite?
AbstractObjective To determine whether human cytomegalovirus (CMV) matrix protein PP150 is efficiently presented for CMV-specific CTL recognition. Methods Recombinant vaccinia virus (Vac. PP150) encoding human CMV structural matrix protein PP150 was constructed with vaccinia vector PSC11 and it was used to stimulate peripheral blood mononuclear cells from 5 CMV seropositive individuals. Results PP150-specific CTLs could be generated in all of them, which not only lysed Vac. PP150-infected fibroblasts, but also lysed CMV-infected targets. In the presence of RNA synthesis inhibitor Actinomycin D (Act D) or at very early stage of infection, PP150-specific CTL lysed CMV-infected targets as efficiently as in the absence of Act D or at late stage of infection. Conclusions PP150 exogenously introduced with the virus infection could be efficiently presented prior to viral DNA replication and PP150 is one of the major target antigens for CTL recognition.
Persistent Identifierhttp://hdl.handle.net/10722/170286
ISSN
2015 Impact Factor: 0.957
2015 SCImago Journal Rankings: 0.428
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Cen_US
dc.contributor.authorYang, Xen_US
dc.contributor.authorTu, Wen_US
dc.contributor.authorRiddell, SRen_US
dc.date.accessioned2012-10-30T06:07:14Z-
dc.date.available2012-10-30T06:07:14Z-
dc.date.issued1997en_US
dc.identifier.citationChinese Medical Journal, 1997, v. 110 n. 5, p. 397-400en_US
dc.identifier.issn0366-6999en_US
dc.identifier.urihttp://hdl.handle.net/10722/170286-
dc.description.abstractObjective To determine whether human cytomegalovirus (CMV) matrix protein PP150 is efficiently presented for CMV-specific CTL recognition. Methods Recombinant vaccinia virus (Vac. PP150) encoding human CMV structural matrix protein PP150 was constructed with vaccinia vector PSC11 and it was used to stimulate peripheral blood mononuclear cells from 5 CMV seropositive individuals. Results PP150-specific CTLs could be generated in all of them, which not only lysed Vac. PP150-infected fibroblasts, but also lysed CMV-infected targets. In the presence of RNA synthesis inhibitor Actinomycin D (Act D) or at very early stage of infection, PP150-specific CTL lysed CMV-infected targets as efficiently as in the absence of Act D or at late stage of infection. Conclusions PP150 exogenously introduced with the virus infection could be efficiently presented prior to viral DNA replication and PP150 is one of the major target antigens for CTL recognition.en_US
dc.languageengen_US
dc.publisherChinese Medical Association. The Journal's web site is located at http://www.cmj.org/en_US
dc.relation.ispartofChinese Medical Journalen_US
dc.subject.meshAntigens, Viral - Immunologyen_US
dc.subject.meshCytomegalovirus - Immunologyen_US
dc.subject.meshCytomegalovirus Infections - Immunology - Virologyen_US
dc.subject.meshCytotoxicity, Immunologicen_US
dc.subject.meshHumansen_US
dc.subject.meshPhosphoproteinsen_US
dc.subject.meshRecombinant Proteins - Immunologyen_US
dc.subject.meshSkin - Virologyen_US
dc.subject.meshT-Lymphocytes - Immunologyen_US
dc.subject.meshViral Matrix Proteins - Analysis - Immunologyen_US
dc.titleHuman cytomegalovirus matrix protein PP150 is efficiently presented as one of target antigens for cytotoxic T lymphocyte recognitionen_US
dc.typeArticleen_US
dc.identifier.emailTu, W:wwtu@hkucc.hku.hken_US
dc.identifier.authorityTu, W=rp00416en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid9594311-
dc.identifier.scopuseid_2-s2.0-0031129897en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031129897&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume110en_US
dc.identifier.issue5en_US
dc.identifier.spage397en_US
dc.identifier.epage400en_US
dc.identifier.isiWOS:A1997XB02300020-
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridLi, C=36072781400en_US
dc.identifier.scopusauthoridYang, X=13606095400en_US
dc.identifier.scopusauthoridTu, W=7006479236en_US
dc.identifier.scopusauthoridRiddell, SR=7005666114en_US

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