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Article: Biology and therapeutic uses of myeloid hematopoietic growth factors and interferons

TitleBiology and therapeutic uses of myeloid hematopoietic growth factors and interferons
Authors
Issue Date1996
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.pidj.com
Citation
Pediatric Infectious Disease Journal, 1996, v. 15 n. 7, p. 563-575 How to Cite?
AbstractRecent advances in basic science and clinical trials have demonstrated that IFNs and myeloid hematopoietins play crucial roles in host defense against pathogens and immune surveillance. Here we have reviewed the biologic functions of GM-CSF, IFN-alpha and IFN-gamma. For patients with neutropenia resulting from cytotoxic chemotherapy, bone marrow transplantation, congenital agranulocytosis and cyclic neutropenia, therapeutic uses of GM- CSF and G-CSF were reviewed. Application of these growth factors to patient management represents a major contribution of biotechnology to a difficult area of therapeutics in febrile, neutropenic patients. Because IFN-alpha plays crucial roles in antiviral responses, its clinical applications in hepatitis B and C, human papilloma virus, HIV infection and malignancy were discussed. The use of IFN-gamma in bacterial prophylaxis in patients with chronic granulomatous disease was also presented. Advances in clinical applications of IFNs and hematopoietic growth factors serve as a paradigm for further development to investigate the use of other important cytokines in modern therapeutics.
Persistent Identifierhttp://hdl.handle.net/10722/170282
ISSN
2015 Impact Factor: 2.587
2015 SCImago Journal Rankings: 1.416
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLau, ASen_US
dc.contributor.authorLehman, Den_US
dc.contributor.authorGeertsma, FRen_US
dc.contributor.authorYeung, MCen_US
dc.date.accessioned2012-10-30T06:07:13Z-
dc.date.available2012-10-30T06:07:13Z-
dc.date.issued1996en_US
dc.identifier.citationPediatric Infectious Disease Journal, 1996, v. 15 n. 7, p. 563-575en_US
dc.identifier.issn0891-3668en_US
dc.identifier.urihttp://hdl.handle.net/10722/170282-
dc.description.abstractRecent advances in basic science and clinical trials have demonstrated that IFNs and myeloid hematopoietins play crucial roles in host defense against pathogens and immune surveillance. Here we have reviewed the biologic functions of GM-CSF, IFN-alpha and IFN-gamma. For patients with neutropenia resulting from cytotoxic chemotherapy, bone marrow transplantation, congenital agranulocytosis and cyclic neutropenia, therapeutic uses of GM- CSF and G-CSF were reviewed. Application of these growth factors to patient management represents a major contribution of biotechnology to a difficult area of therapeutics in febrile, neutropenic patients. Because IFN-alpha plays crucial roles in antiviral responses, its clinical applications in hepatitis B and C, human papilloma virus, HIV infection and malignancy were discussed. The use of IFN-gamma in bacterial prophylaxis in patients with chronic granulomatous disease was also presented. Advances in clinical applications of IFNs and hematopoietic growth factors serve as a paradigm for further development to investigate the use of other important cytokines in modern therapeutics.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.pidj.comen_US
dc.relation.ispartofPediatric Infectious Disease Journalen_US
dc.subject.meshGranulocyte Colony-Stimulating Factor - Physiology - Therapeutic Useen_US
dc.subject.meshGranulocyte-Macrophage Colony-Stimulating Factor - Physiology - Therapeutic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshInterferons - Physiology - Therapeutic Useen_US
dc.subject.meshNeutropenia - Etiology - Therapyen_US
dc.titleBiology and therapeutic uses of myeloid hematopoietic growth factors and interferonsen_US
dc.typeArticleen_US
dc.identifier.emailLau, AS:asylau@hku.hken_US
dc.identifier.authorityLau, AS=rp00474en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00006454-199607000-00002en_US
dc.identifier.pmid8823848-
dc.identifier.scopuseid_2-s2.0-0029984993en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029984993&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume15en_US
dc.identifier.issue7en_US
dc.identifier.spage563en_US
dc.identifier.epage575en_US
dc.identifier.isiWOS:A1996UW72800001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLau, AS=7202626202en_US
dc.identifier.scopusauthoridLehman, D=7005248834en_US
dc.identifier.scopusauthoridGeertsma, FR=6506271158en_US
dc.identifier.scopusauthoridYeung, MC=7101861664en_US

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