File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Identical point mutation leading to low levels of mannose binding protein and poor C3b mediated opsonisation in Chinese and Caucasian populations

TitleIdentical point mutation leading to low levels of mannose binding protein and poor C3b mediated opsonisation in Chinese and Caucasian populations
Authors
Issue Date1992
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/immlet
Citation
Immunology Letters, 1992, v. 32 n. 3, p. 253-257 How to Cite?
AbstractA common opsonic defect occurring in 7% of the Caucasian population is associated with low serum levels of the lectin mannose binding protein (MBP). This study sought to determine whether the deficiency was also present in a Chinese population using sera obtained from 100 healthy Chinese children (age range 6 weeks-16 years). The distribution profiles of MBP levels and C3b/C3bi fragments binding to mannan coated plates were both bimodal and similar to the corresponding Caucasian profiles. Serum MBP levels were low in 9% of the Chinese children and all of these sera generated low levels of C3b/C3bi fragments. Overall there was a high significant correlation between MBP levels and C3b opsonin generation (r = 0.77; P < 0.001). By analogy with similar findings in a Caucasian population we believe this correlation to be a reflection of antibody independent complement activation by MBP. In a pilot study of DNA obtained from three adult Chinese with low MBP levels the point mutation causing MBP deficiency in Caucasians was identified in all three cases.
Persistent Identifierhttp://hdl.handle.net/10722/170260
ISSN
2015 Impact Factor: 2.483
2015 SCImago Journal Rankings: 1.227
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLipscombe, RJen_US
dc.contributor.authorLau, YLen_US
dc.contributor.authorLevinsky, RJen_US
dc.contributor.authorSumiya, Men_US
dc.contributor.authorSummerfield, JAen_US
dc.contributor.authorTurner, MWen_US
dc.date.accessioned2012-10-30T06:07:02Z-
dc.date.available2012-10-30T06:07:02Z-
dc.date.issued1992en_US
dc.identifier.citationImmunology Letters, 1992, v. 32 n. 3, p. 253-257en_US
dc.identifier.issn0165-2478en_US
dc.identifier.urihttp://hdl.handle.net/10722/170260-
dc.description.abstractA common opsonic defect occurring in 7% of the Caucasian population is associated with low serum levels of the lectin mannose binding protein (MBP). This study sought to determine whether the deficiency was also present in a Chinese population using sera obtained from 100 healthy Chinese children (age range 6 weeks-16 years). The distribution profiles of MBP levels and C3b/C3bi fragments binding to mannan coated plates were both bimodal and similar to the corresponding Caucasian profiles. Serum MBP levels were low in 9% of the Chinese children and all of these sera generated low levels of C3b/C3bi fragments. Overall there was a high significant correlation between MBP levels and C3b opsonin generation (r = 0.77; P < 0.001). By analogy with similar findings in a Caucasian population we believe this correlation to be a reflection of antibody independent complement activation by MBP. In a pilot study of DNA obtained from three adult Chinese with low MBP levels the point mutation causing MBP deficiency in Caucasians was identified in all three cases.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/immleten_US
dc.relation.ispartofImmunology Lettersen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshCarrier Proteins - Analysis - Geneticsen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshComplement C3b - Analysisen_US
dc.subject.meshEuropean Continental Ancestry Group - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshMannose-Binding Lectinsen_US
dc.subject.meshMutagenesis, Site-Directeden_US
dc.subject.meshOpsonin Proteins - Blooden_US
dc.titleIdentical point mutation leading to low levels of mannose binding protein and poor C3b mediated opsonisation in Chinese and Caucasian populationsen_US
dc.typeArticleen_US
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_US
dc.identifier.authorityLau, YL=rp00361en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0165-2478(92)90058-Ven_US
dc.identifier.pmid1500095-
dc.identifier.scopuseid_2-s2.0-0026708462en_US
dc.identifier.volume32en_US
dc.identifier.issue3en_US
dc.identifier.spage253en_US
dc.identifier.epage257en_US
dc.identifier.isiWOS:A1992HY82300009-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLipscombe, RJ=6603156821en_US
dc.identifier.scopusauthoridLau, YL=7201403380en_US
dc.identifier.scopusauthoridLevinsky, RJ=7006539367en_US
dc.identifier.scopusauthoridSumiya, M=7006353058en_US
dc.identifier.scopusauthoridSummerfield, JA=7004303597en_US
dc.identifier.scopusauthoridTurner, MW=7403215582en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats