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Article: Regulation of tumor necrosis factor receptor expression by acid-labile interferon-α from AIDS sera

TitleRegulation of tumor necrosis factor receptor expression by acid-labile interferon-α from AIDS sera
Authors
Issue Date1991
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/aid
Citation
Aids Research And Human Retroviruses, 1991, v. 7 n. 6, p. 545-552 How to Cite?
AbstractHigh levels of an unusual acid-labile interferon (IFN) α in sera of patients with human immunodeficiency virus (HIV) infection are associated with disease progression to acquired immunodeficiency syndrome (AIDS). Since IFNs have been shown to enhance the cytotoxic actions of tumor necrosis factor (TNF), a potent mediator of inflammation and cachexia, a study was undertaken to investigate whether the acid-labile IFNα produced in AIDS can regulate TNF receptor expression. The expression of TNF receptors was determined by studying the interaction of [125I]TNF with cellular receptors. The results show the acid-labile IFNα present in AIDS sera is capable of inducing the expression of cellular receptors for TNF. The extent of induction of TNF receptors depends on the concentration of the acid-labile IFNα in the AIDS sera. There is no significant induction of TNF receptors when the AIDS sera are preneutralized with polyclonal anti-IFNα antibodies. It is also shown that the synthesis of TNF by peripheral blood monocytes (PBM) from patients with HIV infection is enhanced during the progression of HIV infection in vivo. Thus, the TNF system is activated in patients with HIV infection. This activation may be a contributing factor to some of the physiological disturbances including the wasting syndrome observed in AIDS.
Persistent Identifierhttp://hdl.handle.net/10722/170247
ISSN
2015 Impact Factor: 1.949
2015 SCImago Journal Rankings: 1.024
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, ASen_US
dc.contributor.authorDer, SDen_US
dc.contributor.authorRead, SEen_US
dc.contributor.authorWilliams, BRGen_US
dc.date.accessioned2012-10-30T06:06:56Z-
dc.date.available2012-10-30T06:06:56Z-
dc.date.issued1991en_US
dc.identifier.citationAids Research And Human Retroviruses, 1991, v. 7 n. 6, p. 545-552en_US
dc.identifier.issn0889-2229en_US
dc.identifier.urihttp://hdl.handle.net/10722/170247-
dc.description.abstractHigh levels of an unusual acid-labile interferon (IFN) α in sera of patients with human immunodeficiency virus (HIV) infection are associated with disease progression to acquired immunodeficiency syndrome (AIDS). Since IFNs have been shown to enhance the cytotoxic actions of tumor necrosis factor (TNF), a potent mediator of inflammation and cachexia, a study was undertaken to investigate whether the acid-labile IFNα produced in AIDS can regulate TNF receptor expression. The expression of TNF receptors was determined by studying the interaction of [125I]TNF with cellular receptors. The results show the acid-labile IFNα present in AIDS sera is capable of inducing the expression of cellular receptors for TNF. The extent of induction of TNF receptors depends on the concentration of the acid-labile IFNα in the AIDS sera. There is no significant induction of TNF receptors when the AIDS sera are preneutralized with polyclonal anti-IFNα antibodies. It is also shown that the synthesis of TNF by peripheral blood monocytes (PBM) from patients with HIV infection is enhanced during the progression of HIV infection in vivo. Thus, the TNF system is activated in patients with HIV infection. This activation may be a contributing factor to some of the physiological disturbances including the wasting syndrome observed in AIDS.en_US
dc.languageengen_US
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/aiden_US
dc.relation.ispartofAIDS Research and Human Retrovirusesen_US
dc.subject.meshAcquired Immunodeficiency Syndrome - Blood - Immunologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAntibodies - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInterferon-Alpha - Blood - Immunologyen_US
dc.subject.meshInterferon-Gamma - Immunologyen_US
dc.subject.meshKineticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMonocytes - Metabolismen_US
dc.subject.meshReceptors, Cell Surface - Biosynthesisen_US
dc.subject.meshReceptors, Tumor Necrosis Factoren_US
dc.subject.meshTumor Necrosis Factor-Alphaen_US
dc.titleRegulation of tumor necrosis factor receptor expression by acid-labile interferon-α from AIDS seraen_US
dc.typeArticleen_US
dc.identifier.emailLau, AS:asylau@hku.hken_US
dc.identifier.authorityLau, AS=rp00474en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1089/aid.1991.7.545-
dc.identifier.pmid1657073-
dc.identifier.scopuseid_2-s2.0-0025914448en_US
dc.identifier.volume7en_US
dc.identifier.issue6en_US
dc.identifier.spage545en_US
dc.identifier.epage552en_US
dc.identifier.isiWOS:A1991FU36100008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLau, AS=7202626202en_US
dc.identifier.scopusauthoridDer, SD=7003963925en_US
dc.identifier.scopusauthoridRead, SE=7101661755en_US
dc.identifier.scopusauthoridWilliams, BRG=7404502964en_US

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