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Article: Downregulation of interferon α but not γ receptor expression in vivo in the acquired immunodeficiency syndrome

TitleDownregulation of interferon α but not γ receptor expression in vivo in the acquired immunodeficiency syndrome
Authors
Issue Date1988
PublisherAmerican Society for Clinical Investigation. The Journal's web site is located at http://www.jci.org
Citation
Journal Of Clinical Investigation, 1988, v. 82 n. 4, p. 1415-1421 How to Cite?
AbstractInterferons (IFN) elicit antiviral and antineoplastic activities by binding to specific receptors on the cell surface. In evaluating the role of IFN as therapeutic agents in AIDS, we investigated the expression of IFNα and γ receptors on peripheral blood mononuclear cells (PBM) from patients with AIDS, ARC, and heterosexual control subjects using radioiodinated IFNα2 and IFNγ. The binding characteristics of the 125I-IFNα and γ to PBM were analyzed to determine receptor numbers and dissociation constants. PBM from controls expressed 498 ± 247 IFNα receptor sites/cell (n = 17). However, eight patients with ARC and seven patients with AIDS had a mean number of IFNα receptor/cell of 286 ± 235 (P < 0.05) and 92 ± 88 (P < 0.001), respectively. This was consistent with elevated levels of serum acid-labile IFNα and cellular 2-5A synthetase activity in patients. Treatment of PBM from the AIDS patients with exogenous IFNα in vitro resulted in minimal 2-5A synthetase induction in comparison to controls. In contrast, the expression of IFNγ receptors in ARC (n = 5) and AIDS (n = 4) patients remained normal. Thus the decrease in IFNα receptor expression and consequent hyporesponsiveness to IFNα raises the question of the usefulness of IFNα therapy in end-stage AIDS. The normal expression of IFNγ receptors in AIDS patients suggests that IFNγ may prove useful in attempts to provide immune reconstitution.
Persistent Identifierhttp://hdl.handle.net/10722/170225
ISSN
2015 Impact Factor: 12.575
2015 SCImago Journal Rankings: 8.764
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, ASen_US
dc.contributor.authorRead, SEen_US
dc.contributor.authorWilliams, BRGen_US
dc.date.accessioned2012-10-30T06:06:49Z-
dc.date.available2012-10-30T06:06:49Z-
dc.date.issued1988en_US
dc.identifier.citationJournal Of Clinical Investigation, 1988, v. 82 n. 4, p. 1415-1421en_US
dc.identifier.issn0021-9738en_US
dc.identifier.urihttp://hdl.handle.net/10722/170225-
dc.description.abstractInterferons (IFN) elicit antiviral and antineoplastic activities by binding to specific receptors on the cell surface. In evaluating the role of IFN as therapeutic agents in AIDS, we investigated the expression of IFNα and γ receptors on peripheral blood mononuclear cells (PBM) from patients with AIDS, ARC, and heterosexual control subjects using radioiodinated IFNα2 and IFNγ. The binding characteristics of the 125I-IFNα and γ to PBM were analyzed to determine receptor numbers and dissociation constants. PBM from controls expressed 498 ± 247 IFNα receptor sites/cell (n = 17). However, eight patients with ARC and seven patients with AIDS had a mean number of IFNα receptor/cell of 286 ± 235 (P < 0.05) and 92 ± 88 (P < 0.001), respectively. This was consistent with elevated levels of serum acid-labile IFNα and cellular 2-5A synthetase activity in patients. Treatment of PBM from the AIDS patients with exogenous IFNα in vitro resulted in minimal 2-5A synthetase induction in comparison to controls. In contrast, the expression of IFNγ receptors in ARC (n = 5) and AIDS (n = 4) patients remained normal. Thus the decrease in IFNα receptor expression and consequent hyporesponsiveness to IFNα raises the question of the usefulness of IFNα therapy in end-stage AIDS. The normal expression of IFNγ receptors in AIDS patients suggests that IFNγ may prove useful in attempts to provide immune reconstitution.en_US
dc.languageengen_US
dc.publisherAmerican Society for Clinical Investigation. The Journal's web site is located at http://www.jci.orgen_US
dc.relation.ispartofJournal of Clinical Investigationen_US
dc.subject.mesh2',5'-Oligoadenylate Synthetase - Metabolismen_US
dc.subject.meshAids-Related Complex - Enzymology - Metabolismen_US
dc.subject.meshAcquired Immunodeficiency Syndrome - Blood - Enzymologyen_US
dc.subject.meshAdulten_US
dc.subject.meshBlood Physiological Phenomenaen_US
dc.subject.meshHumansen_US
dc.subject.meshInterferon Type I - Metabolismen_US
dc.subject.meshInterferon-Gamma - Metabolismen_US
dc.subject.meshLeukocytes, Mononuclear - Classification - Enzymology - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshReceptors, Immunologic - Analysis - Metabolismen_US
dc.subject.meshReceptors, Interferonen_US
dc.titleDownregulation of interferon α but not γ receptor expression in vivo in the acquired immunodeficiency syndromeen_US
dc.typeArticleen_US
dc.identifier.emailLau, AS:asylau@hku.hken_US
dc.identifier.authorityLau, AS=rp00474en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1172/JCI113746-
dc.identifier.pmid2971677-
dc.identifier.scopuseid_2-s2.0-0023709220en_US
dc.identifier.volume82en_US
dc.identifier.issue4en_US
dc.identifier.spage1415en_US
dc.identifier.epage1421en_US
dc.identifier.isiWOS:A1988Q465500036-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLau, AS=7202626202en_US
dc.identifier.scopusauthoridRead, SE=7101661755en_US
dc.identifier.scopusauthoridWilliams, BRG=7404502964en_US

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