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Article: An effective approach by a chelate reaction in optimizing the setting process of strontium-incorporated calcium phosphate bone cement

TitleAn effective approach by a chelate reaction in optimizing the setting process of strontium-incorporated calcium phosphate bone cement
Authors
Issue Date2012
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/
Citation
Journal Of Biomedical Materials Research - Part B Applied Biomaterials, 2012, v. 100 B n. 3, p. 778-787 How to Cite?
AbstractStrontium (Sr) plays a special role in enhancing the biological osteo-stimulation of calcium phosphate cement (CPC), not only increasing osteoblast-related gene expression and the alkaline phosphatase (ALP) activity of mesenchymal stem cells (MSCs), but also inhibiting the differentiation of osteoclasts. However, the incorporation of Sr unfortunately delays the setting of CPC and weakens its mechanical properties. The purpose of this study was to overcome the aforementioned problems by introducing a chelate reaction between Ca/Sr cations from the original solid phases and carboxyl groups from the liquid phases. As expected, the setting process of Sr-incorporated CPC was optimized and the cement body after rapid hardening was mostly consisting of unreacted original solid phases. After soaking in simulated body fluid for 14 and 28 days, the composition of the cement body gradually converted to the most thermodynamic stable phase, hydroxyapatite, indicating an in vitro bioactivity. The compressive strength was not impaired in the Sr-incorporated groups, but rather, further increased over time. Higher cell proliferation rate and better ALP activity of MG-63 cells cultured on the cement surface were obtained with the presence of Sr content, demonstrating potential abilities to favor new bone formation. © 2012 WILEY PERIODICALS, INC.
Persistent Identifierhttp://hdl.handle.net/10722/170205
ISSN
2015 Impact Factor: 2.881
2015 SCImago Journal Rankings: 0.784
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKuang, GMen_US
dc.contributor.authorYau, WPen_US
dc.contributor.authorLam, WMen_US
dc.contributor.authorWu, Jen_US
dc.contributor.authorChiu, KYen_US
dc.contributor.authorLu, WWen_US
dc.contributor.authorPan, Hen_US
dc.date.accessioned2012-10-30T06:06:16Z-
dc.date.available2012-10-30T06:06:16Z-
dc.date.issued2012en_US
dc.identifier.citationJournal Of Biomedical Materials Research - Part B Applied Biomaterials, 2012, v. 100 B n. 3, p. 778-787en_US
dc.identifier.issn1552-4973en_US
dc.identifier.urihttp://hdl.handle.net/10722/170205-
dc.description.abstractStrontium (Sr) plays a special role in enhancing the biological osteo-stimulation of calcium phosphate cement (CPC), not only increasing osteoblast-related gene expression and the alkaline phosphatase (ALP) activity of mesenchymal stem cells (MSCs), but also inhibiting the differentiation of osteoclasts. However, the incorporation of Sr unfortunately delays the setting of CPC and weakens its mechanical properties. The purpose of this study was to overcome the aforementioned problems by introducing a chelate reaction between Ca/Sr cations from the original solid phases and carboxyl groups from the liquid phases. As expected, the setting process of Sr-incorporated CPC was optimized and the cement body after rapid hardening was mostly consisting of unreacted original solid phases. After soaking in simulated body fluid for 14 and 28 days, the composition of the cement body gradually converted to the most thermodynamic stable phase, hydroxyapatite, indicating an in vitro bioactivity. The compressive strength was not impaired in the Sr-incorporated groups, but rather, further increased over time. Higher cell proliferation rate and better ALP activity of MG-63 cells cultured on the cement surface were obtained with the presence of Sr content, demonstrating potential abilities to favor new bone formation. © 2012 WILEY PERIODICALS, INC.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/en_US
dc.relation.ispartofJournal of Biomedical Materials Research - Part B Applied Biomaterialsen_US
dc.rightsJournal of Biomedical Materials Research Part B: Applied Biomaterials. Copyright © John Wiley & Sons, Inc.-
dc.rightsSpecial Statement for Preprint only Before publication: 'This is a preprint of an article accepted for publication in [The Journal of Pathology] Copyright © ([year]) ([Pathological Society of Great Britain and Ireland])'. After publication: the preprint notice should be amended to follows: 'This is a preprint of an article published in [include the complete citation information for the final version of the Contribution as published in the print edition of the Journal]' For Cochrane Library/ Cochrane Database of Systematic Reviews, add statement & acknowledgement : ‘This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 20XX, Issue X. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.’ Please include reference to the Review and hyperlink to the original version using the following format e.g. Authors. Title of Review. Cochrane Database of Systematic Reviews 20XX, Issue #. Art. No.: CD00XXXX. DOI: 10.1002/14651858.CD00XXXX (insert persistent link to the article by using the URL: http://dx.doi.org/10.1002/14651858.CD00XXXX) (This statement should refer to the most recent issue of the Cochrane Database of Systematic Reviews in which the Review published.)-
dc.subject.meshAlkaline Phosphatase - Biosynthesisen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBone Cements - Chemistryen_US
dc.subject.meshCalcium Phosphates - Chemistryen_US
dc.subject.meshCell Lineen_US
dc.subject.meshCell Proliferationen_US
dc.subject.meshMaterials Testingen_US
dc.subject.meshMiceen_US
dc.subject.meshOsteogenesisen_US
dc.subject.meshStrontium - Chemistryen_US
dc.titleAn effective approach by a chelate reaction in optimizing the setting process of strontium-incorporated calcium phosphate bone cementen_US
dc.typeArticleen_US
dc.identifier.emailPan, H:haobo@hku.hken_US
dc.identifier.authorityPan, H=rp01564en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/jbm.b.32511en_US
dc.identifier.pmid22331835-
dc.identifier.scopuseid_2-s2.0-84862798344en_US
dc.identifier.hkuros205831-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84862798344&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume100 Ben_US
dc.identifier.issue3en_US
dc.identifier.spage778en_US
dc.identifier.epage787en_US
dc.identifier.eissn1552-4981-
dc.identifier.isiWOS:000300983700022-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKuang, GM=55262277900en_US
dc.identifier.scopusauthoridYau, WP=55260918600en_US
dc.identifier.scopusauthoridLam, WM=13403256300en_US
dc.identifier.scopusauthoridWu, J=55261999100en_US
dc.identifier.scopusauthoridChiu, KY=34967948100en_US
dc.identifier.scopusauthoridLu, WW=55232825400en_US
dc.identifier.scopusauthoridPan, H=7403295092en_US

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