File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The association of lumbar intervertebral disc degeneration on magnetic resonance imaging with body mass index in overweight and obese adults: a population-based study

TitleThe association of lumbar intervertebral disc degeneration on magnetic resonance imaging with body mass index in overweight and obese adults: a population-based study
Authors
KeywordsBody height
Body mass
Body weight
Clinical assessment
Disease severity
Issue Date2012
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0004-3591/
Citation
Arthritis & Rheumatism, 2012, v. 64 n. 5, p. 1488-1496 How to Cite?
AbstractObjective To investigate the association of being overweight or obese with the presence, extent, and severity of lumbar disc degeneration on magnetic resonance imaging (MRI) in adults. Methods A population-based cross-sectional study of 2,599 southern Chinese volunteers was conducted. Subjects underwent radiographic and clinical assessment, and weight and height were measured. Sagittal T2-weighted MRIs of the lumbar spine were obtained. The presence, extent, and severity of disc degeneration and additional radiographic and clinical parameters were assessed. Asian-modified body mass index (BMI) (kg/m 2) categories were used. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Results The study included 1,040 men and 1,559 women (mean age 41.9 years). Disc degeneration was noted in 1,890 subjects (72.7%). BMI was significantly higher in subjects with disc degeneration (mean 23.3 kg/m 2) than in subjects without degeneration (mean 21.7 kg/m 2) (P < 0.001). A significant increase in the number of degenerated levels (P < 0.001), global severity of disc degeneration (P < 0.001), and end-stage disc degeneration with disc space narrowing (P < 0.001) was noted with elevated BMI, in particular in overweight and obese subjects. In the adjusted multivariate logistic regression model, there was a positive linear trend (r 2 = 0.99) between BMI and the overall presence of disc degeneration in overweight (OR 1.30 [95% CI 1.03-1.62]) and obese (OR 1.79 [95% CI 1.17-2.74]) subjects. End-stage disc degeneration with disc space narrowing was significantly more pronounced in obese subjects (adjusted OR 1.72 [95% CI 1.23-2.41] [reference normal weight]). Conclusion Our findings, in one of the largest studies to systematically assess lumbar disc degeneration on MRI, indicated a significant association between the presence, extent, and global severity of disc degeneration with weight in overweight and obese adults. Copyright © 2012 by the American College of Rheumatology.
Persistent Identifierhttp://hdl.handle.net/10722/170197
ISSN
2015 Impact Factor: 8.955
2015 SCImago Journal Rankings: 3.206
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSamartzis, Den_US
dc.contributor.authorKarppinen, Jen_US
dc.contributor.authorChan, Den_US
dc.contributor.authorLuk, KDKen_US
dc.contributor.authorCheung, KMCen_US
dc.date.accessioned2012-10-30T06:06:06Z-
dc.date.available2012-10-30T06:06:06Z-
dc.date.issued2012en_US
dc.identifier.citationArthritis & Rheumatism, 2012, v. 64 n. 5, p. 1488-1496en_US
dc.identifier.issn0004-3591en_US
dc.identifier.urihttp://hdl.handle.net/10722/170197-
dc.description.abstractObjective To investigate the association of being overweight or obese with the presence, extent, and severity of lumbar disc degeneration on magnetic resonance imaging (MRI) in adults. Methods A population-based cross-sectional study of 2,599 southern Chinese volunteers was conducted. Subjects underwent radiographic and clinical assessment, and weight and height were measured. Sagittal T2-weighted MRIs of the lumbar spine were obtained. The presence, extent, and severity of disc degeneration and additional radiographic and clinical parameters were assessed. Asian-modified body mass index (BMI) (kg/m 2) categories were used. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Results The study included 1,040 men and 1,559 women (mean age 41.9 years). Disc degeneration was noted in 1,890 subjects (72.7%). BMI was significantly higher in subjects with disc degeneration (mean 23.3 kg/m 2) than in subjects without degeneration (mean 21.7 kg/m 2) (P < 0.001). A significant increase in the number of degenerated levels (P < 0.001), global severity of disc degeneration (P < 0.001), and end-stage disc degeneration with disc space narrowing (P < 0.001) was noted with elevated BMI, in particular in overweight and obese subjects. In the adjusted multivariate logistic regression model, there was a positive linear trend (r 2 = 0.99) between BMI and the overall presence of disc degeneration in overweight (OR 1.30 [95% CI 1.03-1.62]) and obese (OR 1.79 [95% CI 1.17-2.74]) subjects. End-stage disc degeneration with disc space narrowing was significantly more pronounced in obese subjects (adjusted OR 1.72 [95% CI 1.23-2.41] [reference normal weight]). Conclusion Our findings, in one of the largest studies to systematically assess lumbar disc degeneration on MRI, indicated a significant association between the presence, extent, and global severity of disc degeneration with weight in overweight and obese adults. Copyright © 2012 by the American College of Rheumatology.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0004-3591/en_US
dc.relation.ispartofArthritis & Rheumatismen_US
dc.rightsArthritis & Rheumatism. Copyright © John Wiley & Sons, Inc.-
dc.subjectBody height-
dc.subjectBody mass-
dc.subjectBody weight-
dc.subjectClinical assessment-
dc.subjectDisease severity-
dc.subject.meshYoung adulten_US
dc.subject.meshPopulation surveillanceen_US
dc.subject.meshOverweight - Epidemiology - Pathologyen_US
dc.subject.meshObesity - Epidemiology - Pathologyen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshMaleen_US
dc.subject.meshMagnetic resonance imaging - Methodsen_US
dc.subject.meshLumbar vertebrae - Pathologyen_US
dc.subject.meshIntervertebral disc degeneration - Epidemiology - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshComorbidityen_US
dc.subject.meshBody mass indexen_US
dc.subject.meshAdulten_US
dc.titleThe association of lumbar intervertebral disc degeneration on magnetic resonance imaging with body mass index in overweight and obese adults: a population-based studyen_US
dc.typeArticleen_US
dc.identifier.emailSamartzis, D: dspine@hku.hken_US
dc.identifier.emailChan, D: chand@hku.hken_US
dc.identifier.emailLuk, KDK: hcm21000@hku.hken_US
dc.identifier.emailCheung, KMC: cheungmc@hku.hk-
dc.identifier.authoritySamartzis, D=rp01430en_US
dc.identifier.authorityChan, D=rp00540en_US
dc.identifier.authorityLuk, KDK=rp00333en_US
dc.identifier.authorityCheung, KMC=rp00387-
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/art.33462en_US
dc.identifier.pmid22287295-
dc.identifier.scopuseid_2-s2.0-84860442850en_US
dc.identifier.hkuros208412-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84860442850&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume64en_US
dc.identifier.issue5en_US
dc.identifier.spage1488en_US
dc.identifier.epage1496en_US
dc.identifier.eissn1529-0131-
dc.identifier.isiWOS:000303239000025-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheung, KMC=7402406754en_US
dc.identifier.scopusauthoridLuk, KDK=55171413200en_US
dc.identifier.scopusauthoridChan, D=7402216545en_US
dc.identifier.scopusauthoridKarppinen, J=7004560479en_US
dc.identifier.scopusauthoridSamartzis, D=34572771100en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats