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Article: The effect of remodeling on the kinematics of the malpositioned disc allograft transplantation

TitleThe effect of remodeling on the kinematics of the malpositioned disc allograft transplantation
Authors
Issue Date2012
PublisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.spinejournal.com
Citation
Spine, 2012, v. 37 n. 6, p. E357-E366 How to Cite?
AbstractSTUDY DESIGN: A postoperative biomechanical study. OBJECTIVE: This study aimed to assess whether the mal-alignment of the intervertebral disc (IVD) allograft during transplantation would negatively affect the biomechanics of the spinal segment. SUMMARY OF BACKGROUND DATA: Studies of human IVD allograft transplantation have observed remodeling of the allograft implant, suggesting that the remodeling of the allograft may be able to restore the natural mechanics of the IVD. METHODS: Eighteen male goats (age: 6-12 months; weight: 25-30 kg) were randomly assigned into control (n = 5), aligned (n = 5), or malpositioned (n = 5) groups. Transplantation of a size-matched cryopreserved IVD allograft was performed in the lumbar region (L4-L5) after disc excision. In the aligned group, the IVD allografts were placed aligned and flush with the anterior vertebral margin. In the malpositioned group, the allografts were placed proud anteriorly by 25% of the anterior-posterior diameter of the allograft. The lumbar spines were harvested at 6 months after transplantation. Three-dimensional kinematic assessment of the lumbar spines was performed using an MTS testing machine and an optoelectronic camera system. The range of motion, neutral zone, and instantaneous axis of rotation were calculated. RESULTS: No significant difference in range of motion was noted between the groups in flexion, axial rotation, and lateral bending. Significance was noted with extension range of motion as detected in both the aligned (17.51 +/- 1.97 degrees; P = 0.019) and malpositioned groups (16.61 +/- 2.35 degrees; P = 0.027) compared with the control (10.11 +/- 1.03 degrees). No significant difference was detected in the neutral zone between the groups. Significant difference in the instantaneous axis of rotation orientation between the malpositioned and control groups was detected in the sagittal plane during lateral bending motion (P = 0.036). CONCLUSION: Kinematic parameters in both the aligned and malpositioned allograft were similar to those of the intact spine. This suggests that precise positioning of the IVD allograft may not be an essential factor affecting the biomechanics of the spinal segment after transplantation.
Persistent Identifierhttp://hdl.handle.net/10722/170195
ISSN
2015 Impact Factor: 2.439
2015 SCImago Journal Rankings: 1.459
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, SKLen_US
dc.contributor.authorXiao, Jen_US
dc.contributor.authorRuan, Den_US
dc.contributor.authorDing, Yen_US
dc.contributor.authorLu, WWen_US
dc.contributor.authorLuk, KDKen_US
dc.date.accessioned2012-10-30T06:06:01Z-
dc.date.available2012-10-30T06:06:01Z-
dc.date.issued2012en_US
dc.identifier.citationSpine, 2012, v. 37 n. 6, p. E357-E366en_US
dc.identifier.issn0362-2436en_US
dc.identifier.urihttp://hdl.handle.net/10722/170195-
dc.description.abstractSTUDY DESIGN: A postoperative biomechanical study. OBJECTIVE: This study aimed to assess whether the mal-alignment of the intervertebral disc (IVD) allograft during transplantation would negatively affect the biomechanics of the spinal segment. SUMMARY OF BACKGROUND DATA: Studies of human IVD allograft transplantation have observed remodeling of the allograft implant, suggesting that the remodeling of the allograft may be able to restore the natural mechanics of the IVD. METHODS: Eighteen male goats (age: 6-12 months; weight: 25-30 kg) were randomly assigned into control (n = 5), aligned (n = 5), or malpositioned (n = 5) groups. Transplantation of a size-matched cryopreserved IVD allograft was performed in the lumbar region (L4-L5) after disc excision. In the aligned group, the IVD allografts were placed aligned and flush with the anterior vertebral margin. In the malpositioned group, the allografts were placed proud anteriorly by 25% of the anterior-posterior diameter of the allograft. The lumbar spines were harvested at 6 months after transplantation. Three-dimensional kinematic assessment of the lumbar spines was performed using an MTS testing machine and an optoelectronic camera system. The range of motion, neutral zone, and instantaneous axis of rotation were calculated. RESULTS: No significant difference in range of motion was noted between the groups in flexion, axial rotation, and lateral bending. Significance was noted with extension range of motion as detected in both the aligned (17.51 +/- 1.97 degrees; P = 0.019) and malpositioned groups (16.61 +/- 2.35 degrees; P = 0.027) compared with the control (10.11 +/- 1.03 degrees). No significant difference was detected in the neutral zone between the groups. Significant difference in the instantaneous axis of rotation orientation between the malpositioned and control groups was detected in the sagittal plane during lateral bending motion (P = 0.036). CONCLUSION: Kinematic parameters in both the aligned and malpositioned allograft were similar to those of the intact spine. This suggests that precise positioning of the IVD allograft may not be an essential factor affecting the biomechanics of the spinal segment after transplantation.en_US
dc.languageengen_US
dc.publisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.spinejournal.comen_US
dc.relation.ispartofSpineen_US
dc.subject.meshBiomechanics - physiologyen_US
dc.subject.meshLumbar Vertebrae - surgeryen_US
dc.subject.meshProstheses and Implantsen_US
dc.subject.meshRange of Motion, Articular - physiologyen_US
dc.subject.meshTotal Disc Replacementen_US
dc.titleThe effect of remodeling on the kinematics of the malpositioned disc allograft transplantationen_US
dc.typeArticleen_US
dc.identifier.emailLam, SKL: skllam@hku.hken_US
dc.identifier.emailLu, WW: wwlu@hku.hken_US
dc.identifier.emailLuk, KDK: hrmoldk@hku.hk-
dc.identifier.authorityLu, WW=rp00411en_US
dc.identifier.authorityLuk, KDK=rp00333en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/BRS.0b013e318232909den_US
dc.identifier.pmid21912315-
dc.identifier.scopuseid_2-s2.0-84858797016en_US
dc.identifier.hkuros207348-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84858797016&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume37en_US
dc.identifier.issue6en_US
dc.identifier.spageE357en_US
dc.identifier.epageE366en_US
dc.identifier.eissn1528-1159-
dc.identifier.isiWOS:000301772300001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLuk, KDK=7201921573en_US
dc.identifier.scopusauthoridLu, WW=7404215221en_US
dc.identifier.scopusauthoridDing, Y=37044095200en_US
dc.identifier.scopusauthoridRuan, D=7004456354en_US
dc.identifier.scopusauthoridXiao, J=49965108000en_US
dc.identifier.scopusauthoridLam, SKL=36622142100en_US

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