Article: Developmental definition of MSCs: New insights into pending questions

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TitleDevelopmental definition of MSCs: New insights into pending questions
AuthorsHuang, S2
Leung, V2
Peng, S2
Li, L2
Lu, FJ2
Wang, T2
Lu, W2
Cheung, KMC2
Zhou, G1 2
Issue Date2011
PublisherMary Ann Liebert, Inc. Publishers. The Journal's web site is located at http://www.liebertpub.com/clo
CitationCellular Reprogramming, 2011, v. 13 n. 6, p. 465-472 [How to Cite?]
DOI: http://dx.doi.org/10.1089/cell.2011.0045
AbstractMesenchymal stem cells (MSCs) are a rare heterogeneous population of multipotent cells that can be isolated from many different adult and fetal tissues. They exhibit the capacity to give rise to cells of multiple lineages and are defined by their phenotype and functional properties, such as spindle-shaped morphology, adherence to plastic, immune response modulation capacity, and multilineage differentiation potential. Accordingly, MSCs have a wide range of promising applications in the treatment of autoimmune diseases, tissue repair, and regeneration. Recent studies have shed some light on the exact identity and native distribution of MSCs, whereas controversial results are still being reported, indicating the need for further review on their definition and origin. In this article, we summarize the important progress and describe some of our own relevant work on the developmental definition of MSCs. © 2011 Mary Ann Liebert, Inc.
ISSN2152-4971
2011 Impact Factor: 2.286
DOIhttp://dx.doi.org/10.1089/cell.2011.0045
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorHuang, S
dc.contributor.authorLeung, V
dc.contributor.authorPeng, S
dc.contributor.authorLi, L
dc.contributor.authorLu, FJ
dc.contributor.authorWang, T
dc.contributor.authorLu, W
dc.contributor.authorCheung, KMC
dc.contributor.authorZhou, G
dc.date.accessioned2012-10-30T06:05:58Z
dc.date.available2012-10-30T06:05:58Z
dc.date.issued2011
dc.description.abstractMesenchymal stem cells (MSCs) are a rare heterogeneous population of multipotent cells that can be isolated from many different adult and fetal tissues. They exhibit the capacity to give rise to cells of multiple lineages and are defined by their phenotype and functional properties, such as spindle-shaped morphology, adherence to plastic, immune response modulation capacity, and multilineage differentiation potential. Accordingly, MSCs have a wide range of promising applications in the treatment of autoimmune diseases, tissue repair, and regeneration. Recent studies have shed some light on the exact identity and native distribution of MSCs, whereas controversial results are still being reported, indicating the need for further review on their definition and origin. In this article, we summarize the important progress and describe some of our own relevant work on the developmental definition of MSCs. © 2011 Mary Ann Liebert, Inc.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationCellular Reprogramming, 2011, v. 13 n. 6, p. 465-472 [How to Cite?]
DOI: http://dx.doi.org/10.1089/cell.2011.0045
dc.identifier.doihttp://dx.doi.org/10.1089/cell.2011.0045
dc.identifier.epage472
dc.identifier.issn2152-4971
2011 Impact Factor: 2.286
dc.identifier.issue6
dc.identifier.pmid21919705
dc.identifier.scopuseid_2-s2.0-83255166464
dc.identifier.spage465
dc.identifier.urihttp://hdl.handle.net/10722/170189
dc.identifier.volume13
dc.languageeng
dc.publisherMary Ann Liebert, Inc. Publishers. The Journal's web site is located at http://www.liebertpub.com/clo
dc.publisher.placeUnited States
dc.relation.ispartofCellular Reprogramming
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshAnimals
dc.subject.meshAutoimmune Diseases - Immunology - Therapy
dc.subject.meshCell Differentiation - Physiology
dc.subject.meshHumans
dc.subject.meshMesenchymal Stem Cell Transplantation
dc.subject.meshMesenchymal Stem Cells - Cytology - Physiology
dc.subject.meshMultipotent Stem Cells - Cytology - Physiology
dc.subject.meshRegeneration - Physiology
dc.titleDevelopmental definition of MSCs: New insights into pending questions
dc.typeArticle
Author Affiliations
  1. Shenzhen University
  2. The University of Hong Kong