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Article: Fabrication of poly(lactic acid) scaffolds by a modified solvent casting/porogen leaching method

TitleFabrication of poly(lactic acid) scaffolds by a modified solvent casting/porogen leaching method
Authors
KeywordsPoly(Lactic Acid)
Porogen Leaching
Porous Scaffold
Tissue Engineering
Issue Date2010
Citation
E-Polymers, 2010 How to Cite?
AbstractA modified solvent casting/particulate leaching (SC/PL) method was developed to fabricate thick three-dimensional poly(lactic acid) (PLA) scaffolds with controlled pore size and porosity, and much shorter processing time. The pasty mixture of PLA/CHCl 3/NaCl was sealed in a Buchner funnel by a piston with a suction flask connected. A vacuum pump was used to facilitate the volatilization of solvent. The scaffolds were obtained by subsequent removal of NaCl in deionized water. The pore size within the scaffold was in good accordance with the particle size of NaCl (< 210, 210∼310, 310∼420 and 420∼500 μm), all of which had more than 89 % of porosity, 1.95 ± 0.2 MPa of compressive modulus and non-cytotoxic to L929 cells. To demonstrate the applicability of the SC/VV/PL method, thick cylindrical and tubular porous scaffolds have been produced in this study. Compared with the traditional SC/PL without vacuum volatilization, the modified method, namely, solvent casting/vacuum volatilization/particulate leaching (SC/VV/PL) method, provide a more efficient way to fabricate thick scaffolds.
Persistent Identifierhttp://hdl.handle.net/10722/170164
ISSN
2015 Impact Factor: 0.812
2015 SCImago Journal Rankings: 0.154
References

 

DC FieldValueLanguage
dc.contributor.authorGong, Xen_US
dc.contributor.authorTang, CYen_US
dc.contributor.authorWong, CTen_US
dc.contributor.authorLu, WWen_US
dc.contributor.authorZhang, Yen_US
dc.contributor.authorLam, WMen_US
dc.contributor.authorWu, Sen_US
dc.contributor.authorLiu, Jen_US
dc.date.accessioned2012-10-30T06:05:44Z-
dc.date.available2012-10-30T06:05:44Z-
dc.date.issued2010en_US
dc.identifier.citationE-Polymers, 2010en_US
dc.identifier.issn1618-7229en_US
dc.identifier.urihttp://hdl.handle.net/10722/170164-
dc.description.abstractA modified solvent casting/particulate leaching (SC/PL) method was developed to fabricate thick three-dimensional poly(lactic acid) (PLA) scaffolds with controlled pore size and porosity, and much shorter processing time. The pasty mixture of PLA/CHCl 3/NaCl was sealed in a Buchner funnel by a piston with a suction flask connected. A vacuum pump was used to facilitate the volatilization of solvent. The scaffolds were obtained by subsequent removal of NaCl in deionized water. The pore size within the scaffold was in good accordance with the particle size of NaCl (< 210, 210∼310, 310∼420 and 420∼500 μm), all of which had more than 89 % of porosity, 1.95 ± 0.2 MPa of compressive modulus and non-cytotoxic to L929 cells. To demonstrate the applicability of the SC/VV/PL method, thick cylindrical and tubular porous scaffolds have been produced in this study. Compared with the traditional SC/PL without vacuum volatilization, the modified method, namely, solvent casting/vacuum volatilization/particulate leaching (SC/VV/PL) method, provide a more efficient way to fabricate thick scaffolds.en_US
dc.languageengen_US
dc.relation.ispartofE-Polymersen_US
dc.subjectPoly(Lactic Acid)en_US
dc.subjectPorogen Leachingen_US
dc.subjectPorous Scaffolden_US
dc.subjectTissue Engineeringen_US
dc.titleFabrication of poly(lactic acid) scaffolds by a modified solvent casting/porogen leaching methoden_US
dc.typeArticleen_US
dc.identifier.emailLu, WW:wwlu@hku.hken_US
dc.identifier.authorityLu, WW=rp00411en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-78349240776en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78349240776&selection=ref&src=s&origin=recordpageen_US
dc.identifier.scopusauthoridGong, X=7201998990en_US
dc.identifier.scopusauthoridTang, CY=7404394088en_US
dc.identifier.scopusauthoridWong, CT=36656837200en_US
dc.identifier.scopusauthoridLu, WW=7404215221en_US
dc.identifier.scopusauthoridZhang, Y=36656701500en_US
dc.identifier.scopusauthoridLam, WM=13403256300en_US
dc.identifier.scopusauthoridWu, S=36656606900en_US
dc.identifier.scopusauthoridLiu, J=36655948100en_US

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