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Article: Effects of surface modification and nanometer material on bone-prosthesis osseointegration in osteoporosis models

TitleEffects of surface modification and nanometer material on bone-prosthesis osseointegration in osteoporosis models
Authors
Issue Date2009
PublisherZhongguo Kangfu Yixuehui. The Journal's web site is located at http://www.zglckf.com/
Citation
Journal Of Clinical Rehabilitative Tissue Engineering Research, 2009, v. 13 n. 25, p. 4811-4814 How to Cite?
AbstractBACKGROUND: Hydroxyapatite (HA) coating can improve the initial and mid-term fixation of prosthesis. However, its long-term stabilization is unsatisfactory. A large number of studies report that nano-HA coating and surface modification of prosthesis can improve the osteointegration at prosthesis-bone interface. Yet, comparative study on osteointegration of nano-materials and surface modification has not been reported. OBJECTIVE: To compare effects of nano-materials and surface modification on osteointegration in osteoporosis (OP) model. DESIGN, TIME AND SETTING: A randomized control experiment was performed in the Animal Experimental Centre of Sun Yat-sun University from September to December 2007 and Histomorphometry Laboratory of the Hong Kong University from March to May 2008, respectively. MATERIALS: Porous HA-coating and surface modified nanometer prostheses sized 3 mm x 3 mm were provided by Department of Materials, South China University of Technology. METHODS: Thirty-two female SD rats, five-month old, were randomly divided into four groups: group A in which rats received sham surgery and was implanted with porous HA, group B in which rats received sham surgery and was implanted with smooth surface nano-HA, group C in which ovariectomized (OVX) rats was implanted with porous HA, and group D in which OVX rats was implanted with smooth surface nano-HA, with eight rats in each group. Rats in group C and D underwent ovariectomy to establish osteoporosis models. Porous and smooth surface HA prostheses were implanted into superior segments of tibia in each group. MAIN OUTCOME MEASURES: At 12 weeks after sacrifice, the bone quantity and osteointegration around the HA implant were observed and the osteointegration at the surface between bone and implant was calculated. RESULTS: Circled digit one; Osteointegration rate (OIS) in group C was 23.7%, which was significantly higher than group D 16.9% (P < 0.05). Circled digit two The OIS in the OVX groups was significantly less than sham surgery groups, reducing 30.8% and 13.0%, respectively. CONCLUSION: Surface modification can notably promote osteointegration at implant-bone interface in osteoporosis condition. The smooth surface of nano-HA prothesis fails to take advantage of the benefit of nano-HA. Referring to HA coating, surface modification of coating plays a more important role in promoting osteointegration, compared to coating material.
Persistent Identifierhttp://hdl.handle.net/10722/170147
ISSN
2015 SCImago Journal Rankings: 0.107
References

 

DC FieldValueLanguage
dc.contributor.authorChen, BLen_US
dc.contributor.authorXie, DHen_US
dc.contributor.authorNing, CYen_US
dc.contributor.authorLü, WJen_US
dc.contributor.authorLi, FBen_US
dc.contributor.authorLiao, WMen_US
dc.contributor.authorXu, DLen_US
dc.date.accessioned2012-10-30T06:05:36Z-
dc.date.available2012-10-30T06:05:36Z-
dc.date.issued2009en_US
dc.identifier.citationJournal Of Clinical Rehabilitative Tissue Engineering Research, 2009, v. 13 n. 25, p. 4811-4814en_US
dc.identifier.issn1673-8225en_US
dc.identifier.urihttp://hdl.handle.net/10722/170147-
dc.description.abstractBACKGROUND: Hydroxyapatite (HA) coating can improve the initial and mid-term fixation of prosthesis. However, its long-term stabilization is unsatisfactory. A large number of studies report that nano-HA coating and surface modification of prosthesis can improve the osteointegration at prosthesis-bone interface. Yet, comparative study on osteointegration of nano-materials and surface modification has not been reported. OBJECTIVE: To compare effects of nano-materials and surface modification on osteointegration in osteoporosis (OP) model. DESIGN, TIME AND SETTING: A randomized control experiment was performed in the Animal Experimental Centre of Sun Yat-sun University from September to December 2007 and Histomorphometry Laboratory of the Hong Kong University from March to May 2008, respectively. MATERIALS: Porous HA-coating and surface modified nanometer prostheses sized 3 mm x 3 mm were provided by Department of Materials, South China University of Technology. METHODS: Thirty-two female SD rats, five-month old, were randomly divided into four groups: group A in which rats received sham surgery and was implanted with porous HA, group B in which rats received sham surgery and was implanted with smooth surface nano-HA, group C in which ovariectomized (OVX) rats was implanted with porous HA, and group D in which OVX rats was implanted with smooth surface nano-HA, with eight rats in each group. Rats in group C and D underwent ovariectomy to establish osteoporosis models. Porous and smooth surface HA prostheses were implanted into superior segments of tibia in each group. MAIN OUTCOME MEASURES: At 12 weeks after sacrifice, the bone quantity and osteointegration around the HA implant were observed and the osteointegration at the surface between bone and implant was calculated. RESULTS: Circled digit one; Osteointegration rate (OIS) in group C was 23.7%, which was significantly higher than group D 16.9% (P < 0.05). Circled digit two The OIS in the OVX groups was significantly less than sham surgery groups, reducing 30.8% and 13.0%, respectively. CONCLUSION: Surface modification can notably promote osteointegration at implant-bone interface in osteoporosis condition. The smooth surface of nano-HA prothesis fails to take advantage of the benefit of nano-HA. Referring to HA coating, surface modification of coating plays a more important role in promoting osteointegration, compared to coating material.en_US
dc.languageengen_US
dc.publisherZhongguo Kangfu Yixuehui. The Journal's web site is located at http://www.zglckf.com/en_US
dc.relation.ispartofJournal of Clinical Rehabilitative Tissue Engineering Researchen_US
dc.titleEffects of surface modification and nanometer material on bone-prosthesis osseointegration in osteoporosis modelsen_US
dc.typeArticleen_US
dc.identifier.emailLü, WJ:wwlu@hku.hken_US
dc.identifier.authorityLü, WJ=rp00411en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.3969/j.issn.1673-8225.2009.25.001en_US
dc.identifier.scopuseid_2-s2.0-67650868961en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67650868961&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume13en_US
dc.identifier.issue25en_US
dc.identifier.spage4811en_US
dc.identifier.epage4814en_US
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridChen, BL=7408611442en_US
dc.identifier.scopusauthoridXie, DH=34874102700en_US
dc.identifier.scopusauthoridNing, CY=9238411800en_US
dc.identifier.scopusauthoridLü, WJ=7404215221en_US
dc.identifier.scopusauthoridLi, FB=8207335500en_US
dc.identifier.scopusauthoridLiao, WM=7203056975en_US
dc.identifier.scopusauthoridXu, DL=7404073854en_US

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