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Article: Solubility of dicalcium phosphate dihydrate by solid titration

TitleSolubility of dicalcium phosphate dihydrate by solid titration
Authors
KeywordsDicalcium phosphate dihydrate
Hydroxyapatite
Solid titration
Issue Date2009
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/CRE
Citation
Caries Research, 2009, v. 43 n. 4, p. 254-260 How to Cite?
AbstractSolid-titration results for hydroxyapatite (HAp), octacalcium phosphate, β-tricalcium phosphate and tetracalcium phosphate have shown that the only stable phase in 100 mmol·l -1 KCl at 37°C is HAp. In particular, dicalcium phosphate dihydrate (DCPD) did not form at pH <4.2 (where it is otherwise believed to be stable) except as a metastable phase under conditions of slight supersaturation. The behaviour of DCPD itself under the same conditions requires checking. Solid titration was used to determine the apparent solubility of DCPD in a 100-mmol·l -1 KCl solution at 37.0 ± 0.1°C over the pH range 3.2-11.6. The constitution of the precipitate was determined by X-ray diffraction, particle morphology was observed by scanning and transmission electron microscopy, and the precipitate Ca/P ratio was calculated by energy-dispersive X-ray analysis. The titration curve for DCPD was substantially lower than the position reported elsewhere. DCPD was the only identified phase at equilibrium at pH 3.60 and 4.50, but HAp was formed after seeding with 1 mg HAp at DCPD equilibrium at pH 4.47, 3.60 and 3.30. It is concluded that the titration curve observed for DCPD corresponds to the solubility isotherm for the phase, but that this represents a metastable equilibrium. HAp is more stable than DCPD, particularly below pH 4.2. The implications for calcium phosphate studies are profound as the reverse is generally believed to be true. Thus, solubility results and the nature of the carious lesion need reconsideration. © 2009 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/170139
ISSN
2015 Impact Factor: 2.278
2015 SCImago Journal Rankings: 1.014
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPan, HBen_HK
dc.contributor.authorDarvell, BWen_HK
dc.date.accessioned2012-10-30T06:05:33Z-
dc.date.available2012-10-30T06:05:33Z-
dc.date.issued2009en_HK
dc.identifier.citationCaries Research, 2009, v. 43 n. 4, p. 254-260en_HK
dc.identifier.issn0008-6568en_HK
dc.identifier.urihttp://hdl.handle.net/10722/170139-
dc.description.abstractSolid-titration results for hydroxyapatite (HAp), octacalcium phosphate, β-tricalcium phosphate and tetracalcium phosphate have shown that the only stable phase in 100 mmol·l -1 KCl at 37°C is HAp. In particular, dicalcium phosphate dihydrate (DCPD) did not form at pH <4.2 (where it is otherwise believed to be stable) except as a metastable phase under conditions of slight supersaturation. The behaviour of DCPD itself under the same conditions requires checking. Solid titration was used to determine the apparent solubility of DCPD in a 100-mmol·l -1 KCl solution at 37.0 ± 0.1°C over the pH range 3.2-11.6. The constitution of the precipitate was determined by X-ray diffraction, particle morphology was observed by scanning and transmission electron microscopy, and the precipitate Ca/P ratio was calculated by energy-dispersive X-ray analysis. The titration curve for DCPD was substantially lower than the position reported elsewhere. DCPD was the only identified phase at equilibrium at pH 3.60 and 4.50, but HAp was formed after seeding with 1 mg HAp at DCPD equilibrium at pH 4.47, 3.60 and 3.30. It is concluded that the titration curve observed for DCPD corresponds to the solubility isotherm for the phase, but that this represents a metastable equilibrium. HAp is more stable than DCPD, particularly below pH 4.2. The implications for calcium phosphate studies are profound as the reverse is generally believed to be true. Thus, solubility results and the nature of the carious lesion need reconsideration. © 2009 S. Karger AG, Basel.en_HK
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/CREen_HK
dc.relation.ispartofCaries Researchen_HK
dc.subjectDicalcium phosphate dihydrateen_HK
dc.subjectHydroxyapatiteen_HK
dc.subjectSolid titrationen_HK
dc.subject.meshBone Substitutes - Chemistryen_US
dc.subject.meshCalcium Phosphates - Chemistryen_US
dc.subject.meshCrystallographyen_US
dc.subject.meshHydroxyapatites - Chemistryen_US
dc.subject.meshPhase Transitionen_US
dc.subject.meshSolubilityen_US
dc.subject.meshTitrimetryen_US
dc.subject.meshX-Ray Diffractionen_US
dc.titleSolubility of dicalcium phosphate dihydrate by solid titrationen_HK
dc.typeArticleen_HK
dc.identifier.emailPan, HB: haobo@hku.hken_HK
dc.identifier.emailDarvell, BW: b.w.darvell@hku.hken_HK
dc.identifier.authorityPan, HB=rp01564en_HK
dc.identifier.authorityDarvell, BW=rp00007en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000217857en_HK
dc.identifier.pmid19439946-
dc.identifier.scopuseid_2-s2.0-65549104731en_HK
dc.identifier.hkuros163519-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-65549104731&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume43en_HK
dc.identifier.issue4en_HK
dc.identifier.spage254en_HK
dc.identifier.epage260en_HK
dc.identifier.isiWOS:000268106900003-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridPan, HB=7403295092en_HK
dc.identifier.scopusauthoridDarvell, BW=7005953926en_HK

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