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Article: Intervertebral disc transplantation in the treatment of degenerative spine disease: a preliminary study

TitleIntervertebral disc transplantation in the treatment of degenerative spine disease: a preliminary study
Authors
Issue Date2007
PublisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
Citation
Lancet, 2007, v. 369 n. 9566, p. 993-999 How to Cite?
AbstractBackground: Spinal fusion can be complicated by accelerated degeneration of the adjacent segments. Artificial disc replacements have been developed, but results are variable. Successful transplantations of intervertebral disc autografts, fresh allografts, and fresh-frozen allografts-ie, a non-fusion strategy-in which the mobility and stability of the spinal segment were preserved have been done in a primate model. Our aim was to determine the feasibility, safety, and long-term clinical results of disc transplantation in human beings. Methods: Five patients, average age 47 years, with cervical disc herniation underwent transplantation of fresh-frozen composite disc allografts after disc excision. Serial MRI and static and dynamic radiographs were used to monitor the status of the grafts and the sagittal stability and mobility of the segment. Findings: Good union of the graft endplates was seen by the end of 3 months after surgery in all patients. At a minimum follow-up of 5 years, the neurological symptoms of all patients had improved from before surgery levels. No immunoreaction was encountered. There was no olisthesis and only mild degenerative changes of the transplanted discs. All except one of the discs showed preservation of 7·0-11·3° of sagittal motion at the final follow-up. MRI at 5 years showed preservation of hydration in at least two discs. Interpretation: Despite signs of mild disc degeneration, the motion and stability of the spinal unit was preserved after transplantation of fresh-frozen allogenic intervertebral discs in our patients. With further refinements, such transplantations could be an effective treatment for degenerative disc disease. © 2007 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/170102
ISSN
2015 Impact Factor: 44.002
2015 SCImago Journal Rankings: 14.638
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRuan, Den_US
dc.contributor.authorHe, Qen_US
dc.contributor.authorDing, Yen_US
dc.contributor.authorHou, Len_US
dc.contributor.authorLi, Jen_US
dc.contributor.authorLuk, KDen_US
dc.date.accessioned2012-10-30T06:05:19Z-
dc.date.available2012-10-30T06:05:19Z-
dc.date.issued2007en_US
dc.identifier.citationLancet, 2007, v. 369 n. 9566, p. 993-999en_US
dc.identifier.issn0140-6736en_US
dc.identifier.urihttp://hdl.handle.net/10722/170102-
dc.description.abstractBackground: Spinal fusion can be complicated by accelerated degeneration of the adjacent segments. Artificial disc replacements have been developed, but results are variable. Successful transplantations of intervertebral disc autografts, fresh allografts, and fresh-frozen allografts-ie, a non-fusion strategy-in which the mobility and stability of the spinal segment were preserved have been done in a primate model. Our aim was to determine the feasibility, safety, and long-term clinical results of disc transplantation in human beings. Methods: Five patients, average age 47 years, with cervical disc herniation underwent transplantation of fresh-frozen composite disc allografts after disc excision. Serial MRI and static and dynamic radiographs were used to monitor the status of the grafts and the sagittal stability and mobility of the segment. Findings: Good union of the graft endplates was seen by the end of 3 months after surgery in all patients. At a minimum follow-up of 5 years, the neurological symptoms of all patients had improved from before surgery levels. No immunoreaction was encountered. There was no olisthesis and only mild degenerative changes of the transplanted discs. All except one of the discs showed preservation of 7·0-11·3° of sagittal motion at the final follow-up. MRI at 5 years showed preservation of hydration in at least two discs. Interpretation: Despite signs of mild disc degeneration, the motion and stability of the spinal unit was preserved after transplantation of fresh-frozen allogenic intervertebral discs in our patients. With further refinements, such transplantations could be an effective treatment for degenerative disc disease. © 2007 Elsevier Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lanceten_US
dc.relation.ispartofLanceten_US
dc.subject.meshAdulten_US
dc.subject.meshCervical Vertebrae - Transplantationen_US
dc.subject.meshFeasibility Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIntervertebral Disc - Transplantationen_US
dc.subject.meshIntervertebral Disc Displacement - Radiography - Surgeryen_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPostoperative Perioden_US
dc.titleIntervertebral disc transplantation in the treatment of degenerative spine disease: a preliminary studyen_US
dc.typeArticleen_US
dc.identifier.emailLuk, KD:hcm21000@hku.hken_US
dc.identifier.authorityLuk, KD=rp00333en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0140-6736(07)60496-6en_US
dc.identifier.pmid17382826-
dc.identifier.scopuseid_2-s2.0-33947278294en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33947278294&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume369en_US
dc.identifier.issue9566en_US
dc.identifier.spage993en_US
dc.identifier.epage999en_US
dc.identifier.eissn1474-547X-
dc.identifier.isiWOS:000245286500028-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridRuan, D=7004456354en_US
dc.identifier.scopusauthoridHe, Q=36951264900en_US
dc.identifier.scopusauthoridDing, Y=37044095200en_US
dc.identifier.scopusauthoridHou, L=25926446500en_US
dc.identifier.scopusauthoridLi, J=37100851200en_US
dc.identifier.scopusauthoridLuk, KD=7201921573en_US

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