File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Transforming growth factor-β1 gene polymorphisms and bone turnover, bone mineral density and fracture risk in southern Chinese women

TitleTransforming growth factor-β1 gene polymorphisms and bone turnover, bone mineral density and fracture risk in southern Chinese women
Authors
Issue Date2004
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00223
Citation
Calcified Tissue International, 2004, v. 74 n. 6, p. 516-521 How to Cite?
AbstractGenetic contributions play an important role in determining bone mineral density (BMD) and bone turnover. Transforming growth factor-β (TGF-β) is abundant in bone and has been implicated as an important regulator of both bone formation and resorption. Several polymorphisms of the TGF-β1 gene have recently been suggested to be associated with BMD and susceptibility to osteoporotic spine fractures. To determine the relationship between TGF-β1 polymorphisms and BMD in southern Chinese women, three SNPs at C -1348-T, T29-C, and T861-20-C of TGF-β1 gene were analyzed in 237 postmenopausal southern Chinese women by RFLP and direct sequencing. BMD at the lumbar spine and hip region, biochemical markers of bone turnover, as well as serum levels of TGF-β1 were measured. Only the T29-C polymorphism of TGF-β1 gene was associated with BMD and fracture risk. The prevalence of fragility fractures was significantly higher in individuals with TC genotype (P < 0.05). Serum alkaline phosphatase and osteocalcin levels as well as urinary N-telopeptide excretion were significantly higher in women with TC than with TT or CC genotypes, and the difference remained significant after adjusting for age and BMI (all P < 0.05). Women with TC genotype had lower BMD at the trochanteric (P < 0.03) and total hip region (P = 0.05). No difference was observed in the serum TGF-β1 levels among the three genotypes. In conclusion, an association between T 29-C polymorphisms of TGF-β1 gene and BMD, bone turnover as well as fragility fractures were demonstrated in postmenopausal southern Chinese women.
Persistent Identifierhttp://hdl.handle.net/10722/170079
ISSN
2015 Impact Factor: 3.052
2015 SCImago Journal Rankings: 1.166
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLau, HHLen_US
dc.contributor.authorHo, AYYen_US
dc.contributor.authorLuk, KDKen_US
dc.contributor.authorKung, AWCen_US
dc.date.accessioned2012-10-30T06:05:11Z-
dc.date.available2012-10-30T06:05:11Z-
dc.date.issued2004en_US
dc.identifier.citationCalcified Tissue International, 2004, v. 74 n. 6, p. 516-521en_US
dc.identifier.issn0171-967Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/170079-
dc.description.abstractGenetic contributions play an important role in determining bone mineral density (BMD) and bone turnover. Transforming growth factor-β (TGF-β) is abundant in bone and has been implicated as an important regulator of both bone formation and resorption. Several polymorphisms of the TGF-β1 gene have recently been suggested to be associated with BMD and susceptibility to osteoporotic spine fractures. To determine the relationship between TGF-β1 polymorphisms and BMD in southern Chinese women, three SNPs at C -1348-T, T29-C, and T861-20-C of TGF-β1 gene were analyzed in 237 postmenopausal southern Chinese women by RFLP and direct sequencing. BMD at the lumbar spine and hip region, biochemical markers of bone turnover, as well as serum levels of TGF-β1 were measured. Only the T29-C polymorphism of TGF-β1 gene was associated with BMD and fracture risk. The prevalence of fragility fractures was significantly higher in individuals with TC genotype (P < 0.05). Serum alkaline phosphatase and osteocalcin levels as well as urinary N-telopeptide excretion were significantly higher in women with TC than with TT or CC genotypes, and the difference remained significant after adjusting for age and BMI (all P < 0.05). Women with TC genotype had lower BMD at the trochanteric (P < 0.03) and total hip region (P = 0.05). No difference was observed in the serum TGF-β1 levels among the three genotypes. In conclusion, an association between T 29-C polymorphisms of TGF-β1 gene and BMD, bone turnover as well as fragility fractures were demonstrated in postmenopausal southern Chinese women.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00223en_US
dc.relation.ispartofCalcified Tissue Internationalen_US
dc.subject.meshAgeden_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshBiological Markers - Analysisen_US
dc.subject.meshBone Density - Geneticsen_US
dc.subject.meshBone Remodelingen_US
dc.subject.meshBone And Bones - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshFractures, Bone - Epidemiology - Etiology - Geneticsen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshOsteoporosis, Postmenopausal - Complications - Epidemiology - Geneticsen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshPolymorphism, Restriction Fragment Lengthen_US
dc.subject.meshRisken_US
dc.subject.meshTransforming Growth Factor Beta - Blood - Geneticsen_US
dc.subject.meshTransforming Growth Factor Beta1en_US
dc.titleTransforming growth factor-β1 gene polymorphisms and bone turnover, bone mineral density and fracture risk in southern Chinese womenen_US
dc.typeArticleen_US
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_US
dc.identifier.emailKung, AWC:awckung@hku.hken_US
dc.identifier.authorityLuk, KDK=rp00333en_US
dc.identifier.authorityKung, AWC=rp00368en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00223-004-0163-4en_US
dc.identifier.pmid15354859-
dc.identifier.scopuseid_2-s2.0-2942683420en_US
dc.identifier.hkuros97923-
dc.identifier.hkuros87823-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2942683420&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume74en_US
dc.identifier.issue6en_US
dc.identifier.spage516en_US
dc.identifier.epage521en_US
dc.identifier.isiWOS:000221931700004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLau, HHL=7201497775en_US
dc.identifier.scopusauthoridHo, AYY=7402675209en_US
dc.identifier.scopusauthoridLuk, KDK=7201921573en_US
dc.identifier.scopusauthoridKung, AWC=7102322339en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats