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Article: The carcinoembryonic antigen (CEA) gene family in non-human primates

TitleThe carcinoembryonic antigen (CEA) gene family in non-human primates
Authors
Issue Date2001
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/gene
Citation
Gene, 2001, v. 264 n. 1, p. 105-112 How to Cite?
AbstractCarcinoembryonic antigen (CEA) is a tumor marker of wide clinical use though its function remains unknown. The CEA counterpart and some related macromolecules cannot be demonstrated in mice, thus prohibiting studies of CEA function by gene disruption strategies. In an attempt to find a relevant animal model for functional studies of CEA we have investigated the occurrence of CEA subgroup members in baboon and African green monkey at the genomic and mRNA levels. The investigation was focused on the characteristic immunoglobulin-variable region-like (IgV-like) N-terminal domain of the family members. Based on N-domain sequences 3 and 4 different CEA subgroup genes, respectively, were identified. One sequence in each monkey species corresponded to human CEACAM8, while it was not possible to assign an obvious human counterpart for the other N-domain sequences. However, studies of cDNAs from African green monkey COS-1 cells identified one of the sequences as CEACAM1. Expression of CEACAM1 mRNA and protein was upregulated by IFNγ as has previously been demonstrated for human CEACAM1. Presence of GPI-linked CEA subgroup members in African green monkey was suggested by sequencing. Both monkey species would thus seem suitable for functional studies of selected CEA subgroup members. © 2001 Elsevier Science B.V.
Persistent Identifierhttp://hdl.handle.net/10722/170039
ISSN
2015 Impact Factor: 2.319
2015 SCImago Journal Rankings: 1.043
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhou, GQen_US
dc.contributor.authorZhang, Yen_US
dc.contributor.authorHammarström, Sen_US
dc.date.accessioned2012-10-30T06:04:53Z-
dc.date.available2012-10-30T06:04:53Z-
dc.date.issued2001en_US
dc.identifier.citationGene, 2001, v. 264 n. 1, p. 105-112en_US
dc.identifier.issn0378-1119en_US
dc.identifier.urihttp://hdl.handle.net/10722/170039-
dc.description.abstractCarcinoembryonic antigen (CEA) is a tumor marker of wide clinical use though its function remains unknown. The CEA counterpart and some related macromolecules cannot be demonstrated in mice, thus prohibiting studies of CEA function by gene disruption strategies. In an attempt to find a relevant animal model for functional studies of CEA we have investigated the occurrence of CEA subgroup members in baboon and African green monkey at the genomic and mRNA levels. The investigation was focused on the characteristic immunoglobulin-variable region-like (IgV-like) N-terminal domain of the family members. Based on N-domain sequences 3 and 4 different CEA subgroup genes, respectively, were identified. One sequence in each monkey species corresponded to human CEACAM8, while it was not possible to assign an obvious human counterpart for the other N-domain sequences. However, studies of cDNAs from African green monkey COS-1 cells identified one of the sequences as CEACAM1. Expression of CEACAM1 mRNA and protein was upregulated by IFNγ as has previously been demonstrated for human CEACAM1. Presence of GPI-linked CEA subgroup members in African green monkey was suggested by sequencing. Both monkey species would thus seem suitable for functional studies of selected CEA subgroup members. © 2001 Elsevier Science B.V.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/geneen_US
dc.relation.ispartofGeneen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCos Cellsen_US
dc.subject.meshCarcinoembryonic Antigen - Geneticsen_US
dc.subject.meshCercopithecus Aethiops - Geneticsen_US
dc.subject.meshDna - Chemistry - Geneticsen_US
dc.subject.meshGene Expression Regulation - Drug Effectsen_US
dc.subject.meshGlycosylphosphatidylinositols - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshInterferon-Gamma - Pharmacologyen_US
dc.subject.meshMembrane Proteins - Genetics - Metabolismen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPapio - Geneticsen_US
dc.subject.meshPhylogenyen_US
dc.subject.meshRna, Messenger - Drug Effects - Genetics - Metabolismen_US
dc.subject.meshRecombinant Proteinsen_US
dc.subject.meshSequence Alignmenten_US
dc.subject.meshSequence Analysis, Dnaen_US
dc.subject.meshSequence Homology, Amino Aciden_US
dc.titleThe carcinoembryonic antigen (CEA) gene family in non-human primatesen_US
dc.typeArticleen_US
dc.identifier.emailZhou, GQ:wormoscz@gmail.comen_US
dc.identifier.authorityZhou, GQ=rp00527en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0378-1119(00)00595-3en_US
dc.identifier.pmid11245984-
dc.identifier.scopuseid_2-s2.0-0035819542en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035819542&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume264en_US
dc.identifier.issue1en_US
dc.identifier.spage105en_US
dc.identifier.epage112en_US
dc.identifier.isiWOS:000167534500013-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridZhou, GQ=23394245100en_US
dc.identifier.scopusauthoridZhang, Y=35346173600en_US
dc.identifier.scopusauthoridHammarström, S=7102117831en_US

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