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Article: Pregnancy-specific glycoprotein (PSG) in baboon (Papio hamadryas): Family size, domain structure, and prediction of a functional region in primate PSGS

TitlePregnancy-specific glycoprotein (PSG) in baboon (Papio hamadryas): Family size, domain structure, and prediction of a functional region in primate PSGS
Authors
Issue Date2001
PublisherSociety for the Study of Reproduction. The Journal's web site is located at http://www.biolreprod.org/
Citation
Biology Of Reproduction, 2001, v. 64 n. 1, p. 90-99 How to Cite?
AbstractPregnancy-specific glycoprotein (PSG) constitutes a major component of serum of pregnant women and appears to be essential for a successful pregnancy. Its function is, however, still unknown. Because of the evolutionary divergence between human and rodent PSG, functional studies may require a primate animal model. We have characterized PSG transcripts in a baboon placenta cDNA library and analyzed baboon genomic DNA. The main PSG isoform had the domain structure N-A1-B2-C similar to the human type IIa isoform. The type I isoform (N-A1-A2-B2-C) was also expressed. Fifteen similar PSG genes were identified of which at least nine were simultaneously expressed in third trimester baboon placenta. Thus, the baboon PSG family was as complex as that of humans. Recombinant baboon PSG (isoform IIa) had a molecular weight of 38 kDa and reacted with antibodies against human PSG. Comparative analysis of 43 N-domain amino acid sequences of PSG from four species and nine primate carcinoembryonic antigen subgroup N domain sequences identified a number of residues in the GFCC′C″ β-sheet and FG loop that are probable candidates for PSG binding to its putative ligand.
Persistent Identifierhttp://hdl.handle.net/10722/170034
ISSN
2015 Impact Factor: 3.471
2015 SCImago Journal Rankings: 1.646
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhou, GQen_US
dc.contributor.authorHammarström, Sen_US
dc.date.accessioned2012-10-30T06:04:52Z-
dc.date.available2012-10-30T06:04:52Z-
dc.date.issued2001en_US
dc.identifier.citationBiology Of Reproduction, 2001, v. 64 n. 1, p. 90-99en_US
dc.identifier.issn0006-3363en_US
dc.identifier.urihttp://hdl.handle.net/10722/170034-
dc.description.abstractPregnancy-specific glycoprotein (PSG) constitutes a major component of serum of pregnant women and appears to be essential for a successful pregnancy. Its function is, however, still unknown. Because of the evolutionary divergence between human and rodent PSG, functional studies may require a primate animal model. We have characterized PSG transcripts in a baboon placenta cDNA library and analyzed baboon genomic DNA. The main PSG isoform had the domain structure N-A1-B2-C similar to the human type IIa isoform. The type I isoform (N-A1-A2-B2-C) was also expressed. Fifteen similar PSG genes were identified of which at least nine were simultaneously expressed in third trimester baboon placenta. Thus, the baboon PSG family was as complex as that of humans. Recombinant baboon PSG (isoform IIa) had a molecular weight of 38 kDa and reacted with antibodies against human PSG. Comparative analysis of 43 N-domain amino acid sequences of PSG from four species and nine primate carcinoembryonic antigen subgroup N domain sequences identified a number of residues in the GFCC′C″ β-sheet and FG loop that are probable candidates for PSG binding to its putative ligand.en_US
dc.languageengen_US
dc.publisherSociety for the Study of Reproduction. The Journal's web site is located at http://www.biolreprod.org/en_US
dc.relation.ispartofBiology of Reproductionen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDna, Complementary - Isolation & Purificationen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expressionen_US
dc.subject.meshGlycoproteins - Chemistry - Genetics - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMiceen_US
dc.subject.meshPapioen_US
dc.subject.meshPhylogenyen_US
dc.subject.meshPlacenta - Metabolismen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Proteins - Chemistry - Genetics - Physiologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRecombinant Proteinsen_US
dc.subject.meshSequence Alignmenten_US
dc.titlePregnancy-specific glycoprotein (PSG) in baboon (Papio hamadryas): Family size, domain structure, and prediction of a functional region in primate PSGSen_US
dc.typeArticleen_US
dc.identifier.emailZhou, GQ:wormoscz@gmail.comen_US
dc.identifier.authorityZhou, GQ=rp00527en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1095/biolreprod64.1.90-
dc.identifier.pmid11133662-
dc.identifier.scopuseid_2-s2.0-0035164023en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035164023&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume64en_US
dc.identifier.issue1en_US
dc.identifier.spage90en_US
dc.identifier.epage99en_US
dc.identifier.isiWOS:000166200200011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhou, GQ=23394245100en_US
dc.identifier.scopusauthoridHammarström, S=7102117831en_US

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