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Article: Preliminary observation on the correlation between nm23 expression and Ki-67 antigen with early metastasis of human osteosarcoma

TitlePreliminary observation on the correlation between nm23 expression and Ki-67 antigen with early metastasis of human osteosarcoma
Authors
Issue Date1998
PublisherZhonghua Yixuehui. The Journal's web site is located at http://www.cmj.org/
Citation
Chinese Medical Journal, 1998, v. 111 n. 9, p. 813-817 How to Cite?
AbstractObjectives To detect the nm23 expression in osteosarcoma, analyze the correlation between nm23 expression and early metastasis and to study the relation between nm23 expression with tumor differentiation and cell proliferation, as defined by Ki-67 labeling. Methods nm23 oncoprotein expression was measured by immunohistochemical staining using formalin fixed, paraffin embedded sections of 39 surgically resected osteosarcomas and was compared with Ki-67 expression, histological findings and early metastasis. In each sample, the grading of immunoreactivity was recorded as 0, 1 +, 2 + according to the percentage of nm23 and Ki-67 labeling cells respectively. Results The cases with more than 25% positive immunoreactivity of nm23 protein were detected in 48.7% of the total cases. There was no statistical difference between nm23 expression and early metastasis, but the cases with nm23 expression appeared to have a trend to get early metastasis. nm23 expression was significantly correlated with Ki-67 expression, which was associated with differentiation of the tumor cells. Conclusion The role of nm23 as a tumor metastasis suppressor in osteosarcoma is less prominent. Both nm23 and Ki-67 may help predict the possibility of early metastasis in human osteosarcomas.
Persistent Identifierhttp://hdl.handle.net/10722/170015
ISSN
2015 Impact Factor: 0.957
2015 SCImago Journal Rankings: 0.428
References

 

DC FieldValueLanguage
dc.contributor.authorLiao, Wen_HK
dc.contributor.authorChiu, KYen_HK
dc.contributor.authorHan, Sen_HK
dc.contributor.authorLi, Fen_HK
dc.contributor.authorQiu, Jen_HK
dc.contributor.authorChow, SPen_HK
dc.date.accessioned2012-10-30T06:04:44Z-
dc.date.available2012-10-30T06:04:44Z-
dc.date.issued1998en_HK
dc.identifier.citationChinese Medical Journal, 1998, v. 111 n. 9, p. 813-817en_HK
dc.identifier.issn0366-6999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/170015-
dc.description.abstractObjectives To detect the nm23 expression in osteosarcoma, analyze the correlation between nm23 expression and early metastasis and to study the relation between nm23 expression with tumor differentiation and cell proliferation, as defined by Ki-67 labeling. Methods nm23 oncoprotein expression was measured by immunohistochemical staining using formalin fixed, paraffin embedded sections of 39 surgically resected osteosarcomas and was compared with Ki-67 expression, histological findings and early metastasis. In each sample, the grading of immunoreactivity was recorded as 0, 1 +, 2 + according to the percentage of nm23 and Ki-67 labeling cells respectively. Results The cases with more than 25% positive immunoreactivity of nm23 protein were detected in 48.7% of the total cases. There was no statistical difference between nm23 expression and early metastasis, but the cases with nm23 expression appeared to have a trend to get early metastasis. nm23 expression was significantly correlated with Ki-67 expression, which was associated with differentiation of the tumor cells. Conclusion The role of nm23 as a tumor metastasis suppressor in osteosarcoma is less prominent. Both nm23 and Ki-67 may help predict the possibility of early metastasis in human osteosarcomas.en_HK
dc.languageengen_US
dc.publisherZhonghua Yixuehui. The Journal's web site is located at http://www.cmj.org/en_HK
dc.relation.ispartofChinese Medical Journalen_HK
dc.titlePreliminary observation on the correlation between nm23 expression and Ki-67 antigen with early metastasis of human osteosarcomaen_HK
dc.typeArticleen_HK
dc.identifier.emailChiu, KY: pkychiu@hkucc.hku.hken_HK
dc.identifier.emailChow, SP: spchow@hku.hken_HK
dc.identifier.authorityChiu, KY=rp00379en_HK
dc.identifier.authorityChow, SP=rp00064en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0032149051en_HK
dc.identifier.hkuros38840-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032149051&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume111en_HK
dc.identifier.issue9en_HK
dc.identifier.spage813en_HK
dc.identifier.epage817en_HK
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridLiao, W=7203056975en_HK
dc.identifier.scopusauthoridChiu, KY=7202988127en_HK
dc.identifier.scopusauthoridHan, S=7405942733en_HK
dc.identifier.scopusauthoridLi, F=8207335500en_HK
dc.identifier.scopusauthoridQiu, J=7403310270en_HK
dc.identifier.scopusauthoridChow, SP=7201828376en_HK

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