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- Publisher Website: 10.1006/bbrc.1995.1862
- Scopus: eid_2-s2.0-0029044905
- PMID: 7794280
- WOS: WOS:A1995RD32400044
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Article: Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants
Title | Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants |
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Authors | |
Issue Date | 1995 |
Publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description |
Citation | Biochemical And Biophysical Research Communications, 1995, v. 211 n. 2, p. 656-664 How to Cite? |
Abstract | The human pregnancy-specific glycoprotein (PSG) family consists of eleven closely related molecules mainly synthesized by placental syncytiotrophoblasts and whose function(s) are unknown. They belong to the carcinoembryonic antigen (CEA) family. As a step toward understanding PSG function, we have analysed 84 PSG cDNA clones from a fetal liver library with respect to domain arrangement and PSG identity. Four novel PSG cDNAs derived from the PSG4 PSG7, PSG11, and PSG13 genes were characterized. The PSG11 and PSG13 cDNAs had novel domain arrangements: L-N-B2-C (named type III) and L-A1-B2-C (named type IV), respectively. These splice variants were also demonstrated in placenta, PSG4 cDNA had a type IIa (L-N-A1-B2-C) and PSG7 cDNA a type I (L-N-A1-A2-B2-C) domain arrangement, PSG1, PSG4, PSG5 were found at highest frequency while PSG8 and PSG12 cDNA clones were not detected. |
Persistent Identifier | http://hdl.handle.net/10722/170004 |
ISSN | 2021 Impact Factor: 3.322 2020 SCImago Journal Rankings: 0.998 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Teglund, S | en_US |
dc.contributor.author | Zhou, G | en_US |
dc.contributor.author | Hammarstrom, S | en_US |
dc.date.accessioned | 2012-10-30T06:04:38Z | - |
dc.date.available | 2012-10-30T06:04:38Z | - |
dc.date.issued | 1995 | en_US |
dc.identifier.citation | Biochemical And Biophysical Research Communications, 1995, v. 211 n. 2, p. 656-664 | en_US |
dc.identifier.issn | 0006-291X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170004 | - |
dc.description.abstract | The human pregnancy-specific glycoprotein (PSG) family consists of eleven closely related molecules mainly synthesized by placental syncytiotrophoblasts and whose function(s) are unknown. They belong to the carcinoembryonic antigen (CEA) family. As a step toward understanding PSG function, we have analysed 84 PSG cDNA clones from a fetal liver library with respect to domain arrangement and PSG identity. Four novel PSG cDNAs derived from the PSG4 PSG7, PSG11, and PSG13 genes were characterized. The PSG11 and PSG13 cDNAs had novel domain arrangements: L-N-B2-C (named type III) and L-A1-B2-C (named type IV), respectively. These splice variants were also demonstrated in placenta, PSG4 cDNA had a type IIa (L-N-A1-B2-C) and PSG7 cDNA a type I (L-N-A1-A2-B2-C) domain arrangement, PSG1, PSG4, PSG5 were found at highest frequency while PSG8 and PSG12 cDNA clones were not detected. | en_US |
dc.language | eng | en_US |
dc.publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description | en_US |
dc.relation.ispartof | Biochemical and Biophysical Research Communications | en_US |
dc.subject.mesh | Amino Acid Sequence | en_US |
dc.subject.mesh | Base Sequence | en_US |
dc.subject.mesh | Cloning, Molecular | en_US |
dc.subject.mesh | Dna Primers | en_US |
dc.subject.mesh | Dna, Complementary | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fetus | en_US |
dc.subject.mesh | Gene Library | en_US |
dc.subject.mesh | Genetic Variation | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Liver - Metabolism | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Molecular Sequence Data | en_US |
dc.subject.mesh | Placenta - Metabolism | en_US |
dc.subject.mesh | Polymerase Chain Reaction | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Pregnancy Proteins - Biosynthesis - Genetics | en_US |
dc.subject.mesh | Transcription, Genetic | en_US |
dc.title | Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants | en_US |
dc.type | Article | en_US |
dc.identifier.email | Zhou, G:wormoscz@gmail.com | en_US |
dc.identifier.authority | Zhou, G=rp00527 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1006/bbrc.1995.1862 | en_US |
dc.identifier.pmid | 7794280 | - |
dc.identifier.scopus | eid_2-s2.0-0029044905 | en_US |
dc.identifier.volume | 211 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 656 | en_US |
dc.identifier.epage | 664 | en_US |
dc.identifier.isi | WOS:A1995RD32400044 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Teglund, S=6602625550 | en_US |
dc.identifier.scopusauthorid | Zhou, G=23394245100 | en_US |
dc.identifier.scopusauthorid | Hammarstrom, S=7102117831 | en_US |
dc.identifier.issnl | 0006-291X | - |