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Article: Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants

TitleCharacterization of cDNA encoding novel pregnancy-specific glycoprotein variants
Authors
Issue Date1995
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 1995, v. 211 n. 2, p. 656-664 How to Cite?
AbstractThe human pregnancy-specific glycoprotein (PSG) family consists of eleven closely related molecules mainly synthesized by placental syncytiotrophoblasts and whose function(s) are unknown. They belong to the carcinoembryonic antigen (CEA) family. As a step toward understanding PSG function, we have analysed 84 PSG cDNA clones from a fetal liver library with respect to domain arrangement and PSG identity. Four novel PSG cDNAs derived from the PSG4 PSG7, PSG11, and PSG13 genes were characterized. The PSG11 and PSG13 cDNAs had novel domain arrangements: L-N-B2-C (named type III) and L-A1-B2-C (named type IV), respectively. These splice variants were also demonstrated in placenta, PSG4 cDNA had a type IIa (L-N-A1-B2-C) and PSG7 cDNA a type I (L-N-A1-A2-B2-C) domain arrangement, PSG1, PSG4, PSG5 were found at highest frequency while PSG8 and PSG12 cDNA clones were not detected.
Persistent Identifierhttp://hdl.handle.net/10722/170004
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTeglund, Sen_US
dc.contributor.authorZhou, Gen_US
dc.contributor.authorHammarstrom, Sen_US
dc.date.accessioned2012-10-30T06:04:38Z-
dc.date.available2012-10-30T06:04:38Z-
dc.date.issued1995en_US
dc.identifier.citationBiochemical And Biophysical Research Communications, 1995, v. 211 n. 2, p. 656-664en_US
dc.identifier.issn0006-291Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/170004-
dc.description.abstractThe human pregnancy-specific glycoprotein (PSG) family consists of eleven closely related molecules mainly synthesized by placental syncytiotrophoblasts and whose function(s) are unknown. They belong to the carcinoembryonic antigen (CEA) family. As a step toward understanding PSG function, we have analysed 84 PSG cDNA clones from a fetal liver library with respect to domain arrangement and PSG identity. Four novel PSG cDNAs derived from the PSG4 PSG7, PSG11, and PSG13 genes were characterized. The PSG11 and PSG13 cDNAs had novel domain arrangements: L-N-B2-C (named type III) and L-A1-B2-C (named type IV), respectively. These splice variants were also demonstrated in placenta, PSG4 cDNA had a type IIa (L-N-A1-B2-C) and PSG7 cDNA a type I (L-N-A1-A2-B2-C) domain arrangement, PSG1, PSG4, PSG5 were found at highest frequency while PSG8 and PSG12 cDNA clones were not detected.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_US
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshCloning, Molecularen_US
dc.subject.meshDna Primersen_US
dc.subject.meshDna, Complementaryen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetusen_US
dc.subject.meshGene Libraryen_US
dc.subject.meshGenetic Variationen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPlacenta - Metabolismen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Proteins - Biosynthesis - Geneticsen_US
dc.subject.meshTranscription, Geneticen_US
dc.titleCharacterization of cDNA encoding novel pregnancy-specific glycoprotein variantsen_US
dc.typeArticleen_US
dc.identifier.emailZhou, G:wormoscz@gmail.comen_US
dc.identifier.authorityZhou, G=rp00527en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1006/bbrc.1995.1862en_US
dc.identifier.pmid7794280-
dc.identifier.scopuseid_2-s2.0-0029044905en_US
dc.identifier.volume211en_US
dc.identifier.issue2en_US
dc.identifier.spage656en_US
dc.identifier.epage664en_US
dc.identifier.isiWOS:A1995RD32400044-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTeglund, S=6602625550en_US
dc.identifier.scopusauthoridZhou, G=23394245100en_US
dc.identifier.scopusauthoridHammarstrom, S=7102117831en_US

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