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Article: Factors underlying prefrontal and insula structural alterations in smokers

TitleFactors underlying prefrontal and insula structural alterations in smokers
Authors
Issue Date2011
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
Neuroimage, 2011, v. 54 n. 1, p. 42-48 How to Cite?
AbstractBased upon previous reports of alterations in white matter integrity and gray matter density in smokers, we examined these markers in a large, well-matched sample of smokers and non-smokers. We further investigated the effect of heavy cigarette exposure by using pack-years and the effects of two relatively stable, highly heritable traits in smokers (Fagerström Test of Nicotine Dependence (FTND), a measure of severity of nicotine dependence and Toronto Alexithymia Scale (TAS-20), a stable personality trait related to smoking). Forty-eight nicotine-dependent subjects and 48 matched controls were included in the analyses, with smokers also subdivided into high/low dependence and high/low pack-years smokers. White matter integrity (fractional anisotropy (FA)) and gray matter density (voxel-based morphometry (VBM)) were measured and compared across groups. Gray matter density was lower in left prefrontal cortex (PFC) in high pack-years smokers and was inversely related to pack-years. In contrast, left insular cortex gray matter density was higher in smokers and associated with TAS-20 total score and with difficulty-identifying-feelings factor. Further, the most highly dependent smokers showed lower prefrontal FA, which was negatively correlated with FTND. There was no correlation between pack-years and FTND in our smoker population. These data suggest chronic tobacco use is correlated with prefrontal gray matter damage , while differences in insula gray matter and PFC white matter appear to reflect stable and heritable differences between smokers and non-smokers. © 2010.
Persistent Identifierhttp://hdl.handle.net/10722/169878
ISSN
2015 Impact Factor: 5.463
2015 SCImago Journal Rankings: 4.464
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Xen_HK
dc.contributor.authorSalmeron, BJen_HK
dc.contributor.authorRoss, TJen_HK
dc.contributor.authorGeng, Xen_HK
dc.contributor.authorYang, Yen_HK
dc.contributor.authorStein, EAen_HK
dc.date.accessioned2012-10-25T04:57:32Z-
dc.date.available2012-10-25T04:57:32Z-
dc.date.issued2011en_HK
dc.identifier.citationNeuroimage, 2011, v. 54 n. 1, p. 42-48en_HK
dc.identifier.issn1053-8119en_HK
dc.identifier.urihttp://hdl.handle.net/10722/169878-
dc.description.abstractBased upon previous reports of alterations in white matter integrity and gray matter density in smokers, we examined these markers in a large, well-matched sample of smokers and non-smokers. We further investigated the effect of heavy cigarette exposure by using pack-years and the effects of two relatively stable, highly heritable traits in smokers (Fagerström Test of Nicotine Dependence (FTND), a measure of severity of nicotine dependence and Toronto Alexithymia Scale (TAS-20), a stable personality trait related to smoking). Forty-eight nicotine-dependent subjects and 48 matched controls were included in the analyses, with smokers also subdivided into high/low dependence and high/low pack-years smokers. White matter integrity (fractional anisotropy (FA)) and gray matter density (voxel-based morphometry (VBM)) were measured and compared across groups. Gray matter density was lower in left prefrontal cortex (PFC) in high pack-years smokers and was inversely related to pack-years. In contrast, left insular cortex gray matter density was higher in smokers and associated with TAS-20 total score and with difficulty-identifying-feelings factor. Further, the most highly dependent smokers showed lower prefrontal FA, which was negatively correlated with FTND. There was no correlation between pack-years and FTND in our smoker population. These data suggest chronic tobacco use is correlated with prefrontal gray matter damage , while differences in insula gray matter and PFC white matter appear to reflect stable and heritable differences between smokers and non-smokers. © 2010.en_HK
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimgen_HK
dc.relation.ispartofNeuroImageen_HK
dc.subject.meshBrain Damage, Chronic - Etiologyen_US
dc.subject.meshCerebral Cortex - Pathologyen_US
dc.subject.meshEmotionsen_US
dc.subject.meshHumansen_US
dc.subject.meshImage Processing, Computer-Assisted - Methodsen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshNerve Degeneration - Pathologyen_US
dc.subject.meshPrefrontal Cortex - Pathologyen_US
dc.subject.meshSmoke - Adverse Effectsen_US
dc.subject.meshSmoking - Genetics - Pathology - Psychologyen_US
dc.subject.meshThinkingen_US
dc.titleFactors underlying prefrontal and insula structural alterations in smokersen_HK
dc.typeArticleen_HK
dc.identifier.emailGeng, X: gengx@hku.hken_HK
dc.identifier.authorityGeng, X=rp01678en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.neuroimage.2010.08.008en_HK
dc.identifier.pmid20699124-
dc.identifier.scopuseid_2-s2.0-77957950710en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77957950710&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume54en_HK
dc.identifier.issue1en_HK
dc.identifier.spage42en_HK
dc.identifier.epage48en_HK
dc.identifier.isiWOS:000283825000007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhang, X=8570352000en_HK
dc.identifier.scopusauthoridSalmeron, BJ=6603367393en_HK
dc.identifier.scopusauthoridRoss, TJ=7203043487en_HK
dc.identifier.scopusauthoridGeng, X=34771310000en_HK
dc.identifier.scopusauthoridYang, Y=7409387192en_HK
dc.identifier.scopusauthoridStein, EA=7202194954en_HK

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