File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Expression of integrin α5β1 and the relationship to collagen and elastin content in human suprarenal and infrarenal aortas

TitleExpression of integrin α5β1 and the relationship to collagen and elastin content in human suprarenal and infrarenal aortas
Authors
Issue Date2005
PublisherSage Publications, Inc. The Journal's web site is located at http://ves.sagepub.com
Citation
Vascular And Endovascular Surgery, 2005, v. 39 n. 3, p. 245-251 How to Cite?
AbstractThe infrarenal aorta is especially prone to the development of aneurysm, suggesting an intrinsic structural and molecular difference in different parts of the aorta. Previous study from this laboratory has implicated a potential role of integrin α5β1 in maintaining aortic integrity. The aim of this study was to investigate the expression of integrin α5β1 and the relationship to collagen and elastin content between 2 different aortic segments. In this study, the variation of smooth muscle cells and the localization of integrin α5β1 in the suprarenal and infrarenal aorta tissues removed from organ donors were studied immunohistochemically. The biochemical analysis for matrix proteins and integrin α5β1 protein was done by Western Blot on the corresponding tissues. All interested protein content was normalized to the smooth muscle α-actin protein. No significant difference of smooth muscle cells density between the 2 segments of aortas was observed. Integrin α5β1 was localized in the outer layer of all aortic media. The authors found that the ratio of collagen/elastin in infrarenal aortas was significantly increased 2-fold because elastin content in infrarenal aortas decreased 49% as compared with suprarenal aortas. Integrin α5β1 content relative to its specific ligand-collagen - did not differ between these 2 different aortic segments. These results suggest that the infrarenal aorta differed biochemically from the suprarenal aorta. A decrease in infrarenal elastin without a corresponding decrease in collagen and integrin α5β1 may affect the compliance and integrity of the distal aorta. These intrinsic anatomic differences may be important in the susceptibility of the infrarenal aortas to aneurysm formation. ©2005 Westminster Publications, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/169747
ISSN
2015 Impact Factor: 0.782
2015 SCImago Journal Rankings: 0.438
References

 

DC FieldValueLanguage
dc.contributor.authorCheuk, BLYen_US
dc.contributor.authorCheng, SWKen_US
dc.date.accessioned2012-10-25T04:54:49Z-
dc.date.available2012-10-25T04:54:49Z-
dc.date.issued2005en_US
dc.identifier.citationVascular And Endovascular Surgery, 2005, v. 39 n. 3, p. 245-251en_US
dc.identifier.issn1538-5744en_US
dc.identifier.urihttp://hdl.handle.net/10722/169747-
dc.description.abstractThe infrarenal aorta is especially prone to the development of aneurysm, suggesting an intrinsic structural and molecular difference in different parts of the aorta. Previous study from this laboratory has implicated a potential role of integrin α5β1 in maintaining aortic integrity. The aim of this study was to investigate the expression of integrin α5β1 and the relationship to collagen and elastin content between 2 different aortic segments. In this study, the variation of smooth muscle cells and the localization of integrin α5β1 in the suprarenal and infrarenal aorta tissues removed from organ donors were studied immunohistochemically. The biochemical analysis for matrix proteins and integrin α5β1 protein was done by Western Blot on the corresponding tissues. All interested protein content was normalized to the smooth muscle α-actin protein. No significant difference of smooth muscle cells density between the 2 segments of aortas was observed. Integrin α5β1 was localized in the outer layer of all aortic media. The authors found that the ratio of collagen/elastin in infrarenal aortas was significantly increased 2-fold because elastin content in infrarenal aortas decreased 49% as compared with suprarenal aortas. Integrin α5β1 content relative to its specific ligand-collagen - did not differ between these 2 different aortic segments. These results suggest that the infrarenal aorta differed biochemically from the suprarenal aorta. A decrease in infrarenal elastin without a corresponding decrease in collagen and integrin α5β1 may affect the compliance and integrity of the distal aorta. These intrinsic anatomic differences may be important in the susceptibility of the infrarenal aortas to aneurysm formation. ©2005 Westminster Publications, Inc.en_US
dc.languageengen_US
dc.publisherSage Publications, Inc. The Journal's web site is located at http://ves.sagepub.comen_US
dc.relation.ispartofVascular and Endovascular Surgeryen_US
dc.rightsVascular and Endovascular Surgery. Copyright © Sage Publications, Inc.-
dc.subject.meshAorta, Abdominal - Cytology - Metabolismen_US
dc.subject.meshBlotting, Westernen_US
dc.subject.meshCollagen Type I - Metabolismen_US
dc.subject.meshElastin - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshIntegrin Alpha5beta1 - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMuscle, Smooth - Cytologyen_US
dc.titleExpression of integrin α5β1 and the relationship to collagen and elastin content in human suprarenal and infrarenal aortasen_US
dc.typeArticleen_US
dc.identifier.emailCheuk, BLY: bernice@hku.hken_US
dc.identifier.emailCheng, SWK: wkcheng@hkucc.hku.hken_US
dc.identifier.authorityCheuk, BLY=rp01671en_US
dc.identifier.authorityCheng, SWK=rp00374en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1177/153857440503900305en_US
dc.identifier.pmid15920653-
dc.identifier.scopuseid_2-s2.0-19444372269en_US
dc.identifier.hkuros98697-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-19444372269&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume39en_US
dc.identifier.issue3en_US
dc.identifier.spage245en_US
dc.identifier.epage251en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheuk, BLY=7801343617en_US
dc.identifier.scopusauthoridCheng, SWK=7404684779en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats