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Article: Interference with the formation of the epididymal microenvironment - A new strategy for male contraception ?

TitleInterference with the formation of the epididymal microenvironment - A new strategy for male contraception ?
Authors
KeywordsContraception
Cyclooxygenase
Cystic Fibrosis Transmembrane Conductance Regulator
Epididymis
Issue Date2000
PublisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1008-682X&site=1
Citation
Asian Journal Of Andrology, 2000, v. 2 n. 1, p. 39-45 How to Cite?
AbstractThe cystic fibrosis transmembrane conductance regulator (CFTR) or the small conductance cAMP-activated chloride channel encoded by the CFTR gene has been shown to play an important role in the formation of the epididymal fluid microenvironment. Recent work in our laboratory has shown that this protein is also expressed by developing germ cells indicating a role of this protein in spermatogenesis. In view of the fact that the CFTR gene has a far reaching and widespread effect on human reproduction, understanding the role of CFTR in the male reproductive tissues and its intervention by pharmacological agents can open a new avenue of research into the development of novel male contraceptives. © 2000, Asian Journal of Andrology.
Persistent Identifierhttp://hdl.handle.net/10722/169743
ISSN
2015 Impact Factor: 2.644
2015 SCImago Journal Rankings: 0.879
References

 

DC FieldValueLanguage
dc.contributor.authorGong, XDen_US
dc.contributor.authorLeung, GPHen_US
dc.contributor.authorCheuk, BLYen_US
dc.contributor.authorWong, PYDen_US
dc.date.accessioned2012-10-25T04:54:48Z-
dc.date.available2012-10-25T04:54:48Z-
dc.date.issued2000en_US
dc.identifier.citationAsian Journal Of Andrology, 2000, v. 2 n. 1, p. 39-45en_US
dc.identifier.issn1008-682Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/169743-
dc.description.abstractThe cystic fibrosis transmembrane conductance regulator (CFTR) or the small conductance cAMP-activated chloride channel encoded by the CFTR gene has been shown to play an important role in the formation of the epididymal fluid microenvironment. Recent work in our laboratory has shown that this protein is also expressed by developing germ cells indicating a role of this protein in spermatogenesis. In view of the fact that the CFTR gene has a far reaching and widespread effect on human reproduction, understanding the role of CFTR in the male reproductive tissues and its intervention by pharmacological agents can open a new avenue of research into the development of novel male contraceptives. © 2000, Asian Journal of Andrology.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1008-682X&site=1en_US
dc.relation.ispartofAsian Journal of Andrologyen_US
dc.subjectContraceptionen_US
dc.subjectCyclooxygenaseen_US
dc.subjectCystic Fibrosis Transmembrane Conductance Regulatoren_US
dc.subjectEpididymisen_US
dc.titleInterference with the formation of the epididymal microenvironment - A new strategy for male contraception ?en_US
dc.typeArticleen_US
dc.identifier.emailLeung, GPH: gphleung@hkucc.hku.hken_US
dc.identifier.emailCheuk, BLY: bernice@hku.hken_US
dc.identifier.authorityLeung, GPH=rp00234en_US
dc.identifier.authorityCheuk, BLY=rp01671en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0034158038en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034158038&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume2en_US
dc.identifier.issue1en_US
dc.identifier.spage39en_US
dc.identifier.epage45en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGong, XD=7201999007en_US
dc.identifier.scopusauthoridLeung, GPH=35963668200en_US
dc.identifier.scopusauthoridCheuk, BLY=7801343617en_US
dc.identifier.scopusauthoridWong, PYD=7403980262en_US

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