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Article: In vitro and in vivo characteristics of stem cells derived from the periodontal ligament of human deciduous and permanent teeth

TitleIn vitro and in vivo characteristics of stem cells derived from the periodontal ligament of human deciduous and permanent teeth
Authors
Issue Date2012
PublisherMary Ann Liebert, Inc. Publishers. The Journal's web site is located at http://www.liebertpub.com/publication.aspx?pub_id=263
Citation
Tissue Engineering - Part A, 2012, v. 18 n. 19-20, p. 2040-2051 How to Cite?
Abstract
In many studies, adult stem cells have been found in human periodontal ligament (PDL), but in most cases they were found in the permanent teeth. The aim of the present study was to characterize stem cells from the PDL of deciduous teeth (dPDLSCs) and compare them with those from the PDL of permanent teeth (pPDLSCs). Stem cell markers were examined by a flow cytometric analysis. The results of in vitro differentiation into adipogenic and osteogenic lineages were analyzed by histochemical staining and quantitative reverse transcription-polymerase chain reaction (RT-PCR). The results of in vivo transplantation were analyzed by histological staining, immunohistochemical staining, and quantitative RT-PCR. There were no significant differences in the proliferation rate, cell cycle distribution, expressions of stem cell markers such as Stro-1 and CD146, or in vitro differentiation. The pPDLSC transplants made more typical cementum/PDL-like tissues and expressed more cementum/PDL-related genes (CP23 and collagen XII) than did the dPDLSC transplants. Together, these results suggest that pPDLSCs are better candidates for use in reconstructing periodontium. © Copyright 2012, Mary Ann Liebert, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/169596
ISSN
2013 SCImago Journal Rankings: 1.683
ISI Accession Number ID
References

 

Author Affiliations
  1. Yonsei University
DC FieldValueLanguage
dc.contributor.authorSong, JSen_US
dc.contributor.authorKim, SOen_US
dc.contributor.authorKim, SHen_US
dc.contributor.authorChoi, HJen_US
dc.contributor.authorSon, HKen_US
dc.contributor.authorJung, HSen_US
dc.contributor.authorKim, CSen_US
dc.contributor.authorLee, JHen_US
dc.date.accessioned2012-10-25T04:53:18Z-
dc.date.available2012-10-25T04:53:18Z-
dc.date.issued2012en_US
dc.identifier.citationTissue Engineering - Part A, 2012, v. 18 n. 19-20, p. 2040-2051en_US
dc.identifier.issn1937-3341en_US
dc.identifier.urihttp://hdl.handle.net/10722/169596-
dc.description.abstractIn many studies, adult stem cells have been found in human periodontal ligament (PDL), but in most cases they were found in the permanent teeth. The aim of the present study was to characterize stem cells from the PDL of deciduous teeth (dPDLSCs) and compare them with those from the PDL of permanent teeth (pPDLSCs). Stem cell markers were examined by a flow cytometric analysis. The results of in vitro differentiation into adipogenic and osteogenic lineages were analyzed by histochemical staining and quantitative reverse transcription-polymerase chain reaction (RT-PCR). The results of in vivo transplantation were analyzed by histological staining, immunohistochemical staining, and quantitative RT-PCR. There were no significant differences in the proliferation rate, cell cycle distribution, expressions of stem cell markers such as Stro-1 and CD146, or in vitro differentiation. The pPDLSC transplants made more typical cementum/PDL-like tissues and expressed more cementum/PDL-related genes (CP23 and collagen XII) than did the dPDLSC transplants. Together, these results suggest that pPDLSCs are better candidates for use in reconstructing periodontium. © Copyright 2012, Mary Ann Liebert, Inc.en_US
dc.languageengen_US
dc.publisherMary Ann Liebert, Inc. Publishers. The Journal's web site is located at http://www.liebertpub.com/publication.aspx?pub_id=263en_US
dc.relation.ispartofTissue Engineering - Part Aen_US
dc.titleIn vitro and in vivo characteristics of stem cells derived from the periodontal ligament of human deciduous and permanent teethen_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1089/ten.tea.2011.0318en_US
dc.identifier.pmid22571499-
dc.identifier.scopuseid_2-s2.0-84867009349en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84867009349&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume18en_US
dc.identifier.issue19-20en_US
dc.identifier.spage2040en_US
dc.identifier.epage2051en_US
dc.identifier.isiWOS:000310118500011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSong, JS=55279270500en_US
dc.identifier.scopusauthoridKim, SO=35324763800en_US
dc.identifier.scopusauthoridKim, SH=53164290900en_US
dc.identifier.scopusauthoridChoi, HJ=15070217900en_US
dc.identifier.scopusauthoridSon, HK=12769270800en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US
dc.identifier.scopusauthoridKim, CS=35429072600en_US
dc.identifier.scopusauthoridLee, JH=7601451606en_US

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