File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Effect of diode laser on proliferation and differentiation of PC12 cells.

TitleEffect of diode laser on proliferation and differentiation of PC12 cells.
Authors
Issue Date2011
Citation
The Bulletin Of Tokyo Dental College, 2011, v. 52 n. 2, p. 95-102 How to Cite?
AbstractThis study investigated the effects of diode (GaAlAs) laser irradiation at an effective energy density of 5 or 20 J/cm(2) on cell growth factor-induced differentiation and proliferation in pheochromocytoma cells (PC12 cells), and whether those effects were related to activation of the p38 pathway. Laser irradiation at 20 J/cm(2) significantly decreased the number of PC12 cells, while no difference was seen between the 5 J/cm(2) group and the control group (p<0.05). Western blotting revealed marked expression of neurofilament and β-tubulin, indicating greater neurite differentiation in the irradiation groups than in the control group at 48 hr. Irradiation also enhanced expression of phospho-p38. The decrease in number of cells after laser irradiation was accelerated by p38 inhibitor, while neurite differentiation was up-regulated by laser irradiation, even when the p38 pathway was blocked. This suggests that laser irradiation up-regulated neurite differentiation in PC12 cells involving p38 and another pathway.
Persistent Identifierhttp://hdl.handle.net/10722/169586
ISSN
2015 SCImago Journal Rankings: 0.148

 

DC FieldValueLanguage
dc.contributor.authorSaito, Ken_US
dc.contributor.authorHashimoto, Sen_US
dc.contributor.authorJung, HSen_US
dc.contributor.authorShimono, Men_US
dc.contributor.authorNakagawa, Ken_US
dc.date.accessioned2012-10-25T04:53:11Z-
dc.date.available2012-10-25T04:53:11Z-
dc.date.issued2011en_US
dc.identifier.citationThe Bulletin Of Tokyo Dental College, 2011, v. 52 n. 2, p. 95-102en_US
dc.identifier.issn0040-8891en_US
dc.identifier.urihttp://hdl.handle.net/10722/169586-
dc.description.abstractThis study investigated the effects of diode (GaAlAs) laser irradiation at an effective energy density of 5 or 20 J/cm(2) on cell growth factor-induced differentiation and proliferation in pheochromocytoma cells (PC12 cells), and whether those effects were related to activation of the p38 pathway. Laser irradiation at 20 J/cm(2) significantly decreased the number of PC12 cells, while no difference was seen between the 5 J/cm(2) group and the control group (p<0.05). Western blotting revealed marked expression of neurofilament and β-tubulin, indicating greater neurite differentiation in the irradiation groups than in the control group at 48 hr. Irradiation also enhanced expression of phospho-p38. The decrease in number of cells after laser irradiation was accelerated by p38 inhibitor, while neurite differentiation was up-regulated by laser irradiation, even when the p38 pathway was blocked. This suggests that laser irradiation up-regulated neurite differentiation in PC12 cells involving p38 and another pathway.en_US
dc.languageengen_US
dc.relation.ispartofThe Bulletin of Tokyo Dental Collegeen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Differentiation - Radiation Effectsen_US
dc.subject.meshCell Proliferation - Radiation Effectsen_US
dc.subject.meshLaser Therapy, Low-Levelen_US
dc.subject.meshLasers, Semiconductoren_US
dc.subject.meshMap Kinase Signaling System - Physiologyen_US
dc.subject.meshNerve Growth Factor - Pharmacologyen_US
dc.subject.meshNerve Regeneration - Radiation Effectsen_US
dc.subject.meshNeurites - Drug Effects - Metabolism - Radiation Effectsen_US
dc.subject.meshNeurofilament Proteins - Biosynthesisen_US
dc.subject.meshPc12 Cells - Radiation Effectsen_US
dc.subject.meshRatsen_US
dc.subject.meshTubulin - Biosynthesisen_US
dc.subject.meshUp-Regulationen_US
dc.subject.meshP38 Mitogen-Activated Protein Kinases - Metabolismen_US
dc.titleEffect of diode laser on proliferation and differentiation of PC12 cells.en_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.2209/tdcpublication.52.95en_US
dc.identifier.pmid21701122-
dc.identifier.scopuseid_2-s2.0-80054818214en_US
dc.identifier.volume52en_US
dc.identifier.issue2en_US
dc.identifier.spage95en_US
dc.identifier.epage102en_US
dc.identifier.scopusauthoridSaito, K=54380519900en_US
dc.identifier.scopusauthoridHashimoto, S=35556628400en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US
dc.identifier.scopusauthoridShimono, M=7006406232en_US
dc.identifier.scopusauthoridNakagawa, K=35404162500en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats