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Article: Reciprocal interactions of Fgf10/Fgfr2b modulate the mouse tongue epithelial differentiation
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TitleReciprocal interactions of Fgf10/Fgfr2b modulate the mouse tongue epithelial differentiation
 
AuthorsSohn, WJ3
Jung, HI3
Choi, MA3
Han, JH3
Gwon, GJ3
Yamamoto, H2
Lee, S3
Ryoo, ZY3
Park, EK3
Shin, HI3
Jung, HS1
Kim, JY3
 
Issue Date2011
 
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
 
CitationCell And Tissue Research, 2011, v. 345 n. 2, p. 265-273 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00441-011-1204-8
 
AbstractThe molecular mechanisms for epithelial differentiation have been studied by observing skin development in embryogenesis, but the early signaling modulations involved in tongue epithelial differentiation are not completely understood. Based on the gene expression patterns of the Fgf signaling molecules and previous results from Fgf10 and Fgfr2b knockout mice, it was hypothesized that there would be fundamental signaling interactions through the epithelial Fgfr2b and its mesenchymal ligand Fgf10 to regulate tongue epithelium differentiation. To elucidate these reciprocal interactions in tongue epithelial differentiation, this study employed an in vitro tongue organ culture system with antisense-oligodeoxynucleotides (AS-ODNs) and recombinant protein-soaked bead implantation for the loss-of-function and gain-of-function studies. Functional analysis of Fgf signaling revealed precise reciprocal interactions, which showed that mesenchymal Fgf10 rather than Fgf7 modulates tongue epithelial differentiation via Fgfr2b in a temporal- and spatial-specific manner. © 2011 Springer-Verlag.
 
ISSN0302-766X
2013 Impact Factor: 3.333
 
DOIhttp://dx.doi.org/10.1007/s00441-011-1204-8
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorSohn, WJ
 
dc.contributor.authorJung, HI
 
dc.contributor.authorChoi, MA
 
dc.contributor.authorHan, JH
 
dc.contributor.authorGwon, GJ
 
dc.contributor.authorYamamoto, H
 
dc.contributor.authorLee, S
 
dc.contributor.authorRyoo, ZY
 
dc.contributor.authorPark, EK
 
dc.contributor.authorShin, HI
 
dc.contributor.authorJung, HS
 
dc.contributor.authorKim, JY
 
dc.date.accessioned2012-10-25T04:53:10Z
 
dc.date.available2012-10-25T04:53:10Z
 
dc.date.issued2011
 
dc.description.abstractThe molecular mechanisms for epithelial differentiation have been studied by observing skin development in embryogenesis, but the early signaling modulations involved in tongue epithelial differentiation are not completely understood. Based on the gene expression patterns of the Fgf signaling molecules and previous results from Fgf10 and Fgfr2b knockout mice, it was hypothesized that there would be fundamental signaling interactions through the epithelial Fgfr2b and its mesenchymal ligand Fgf10 to regulate tongue epithelium differentiation. To elucidate these reciprocal interactions in tongue epithelial differentiation, this study employed an in vitro tongue organ culture system with antisense-oligodeoxynucleotides (AS-ODNs) and recombinant protein-soaked bead implantation for the loss-of-function and gain-of-function studies. Functional analysis of Fgf signaling revealed precise reciprocal interactions, which showed that mesenchymal Fgf10 rather than Fgf7 modulates tongue epithelial differentiation via Fgfr2b in a temporal- and spatial-specific manner. © 2011 Springer-Verlag.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationCell And Tissue Research, 2011, v. 345 n. 2, p. 265-273 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00441-011-1204-8
 
dc.identifier.citeulike9513875
 
dc.identifier.doihttp://dx.doi.org/10.1007/s00441-011-1204-8
 
dc.identifier.epage273
 
dc.identifier.issn0302-766X
2013 Impact Factor: 3.333
 
dc.identifier.issue2
 
dc.identifier.pmid21720756
 
dc.identifier.scopuseid_2-s2.0-80052698289
 
dc.identifier.spage265
 
dc.identifier.urihttp://hdl.handle.net/10722/169584
 
dc.identifier.volume345
 
dc.languageeng
 
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
 
dc.publisher.placeGermany
 
dc.relation.ispartofCell and Tissue Research
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAnimals
 
dc.subject.meshCell Differentiation - Physiology
 
dc.subject.meshEpithelial Cells - Cytology - Metabolism
 
dc.subject.meshFibroblast Growth Factor 10 - Genetics - Metabolism
 
dc.subject.meshMice
 
dc.subject.meshMice, Inbred Icr
 
dc.subject.meshMice, Knockout
 
dc.subject.meshReceptor, Fibroblast Growth Factor, Type 2 - Genetics - Metabolism
 
dc.subject.meshSignal Transduction
 
dc.subject.meshTongue - Cytology - Metabolism
 
dc.titleReciprocal interactions of Fgf10/Fgfr2b modulate the mouse tongue epithelial differentiation
 
dc.typeArticle
 
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<contributor.author>Han, JH</contributor.author>
<contributor.author>Gwon, GJ</contributor.author>
<contributor.author>Yamamoto, H</contributor.author>
<contributor.author>Lee, S</contributor.author>
<contributor.author>Ryoo, ZY</contributor.author>
<contributor.author>Park, EK</contributor.author>
<contributor.author>Shin, HI</contributor.author>
<contributor.author>Jung, HS</contributor.author>
<contributor.author>Kim, JY</contributor.author>
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Author Affiliations
  1. Yonsei University
  2. Nihon University
  3. Kyungpook National University