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Article: Reciprocal interactions of Fgf10/Fgfr2b modulate the mouse tongue epithelial differentiation

TitleReciprocal interactions of Fgf10/Fgfr2b modulate the mouse tongue epithelial differentiation
Authors
Issue Date2011
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
Citation
Cell And Tissue Research, 2011, v. 345 n. 2, p. 265-273 How to Cite?
Abstract
The molecular mechanisms for epithelial differentiation have been studied by observing skin development in embryogenesis, but the early signaling modulations involved in tongue epithelial differentiation are not completely understood. Based on the gene expression patterns of the Fgf signaling molecules and previous results from Fgf10 and Fgfr2b knockout mice, it was hypothesized that there would be fundamental signaling interactions through the epithelial Fgfr2b and its mesenchymal ligand Fgf10 to regulate tongue epithelium differentiation. To elucidate these reciprocal interactions in tongue epithelial differentiation, this study employed an in vitro tongue organ culture system with antisense-oligodeoxynucleotides (AS-ODNs) and recombinant protein-soaked bead implantation for the loss-of-function and gain-of-function studies. Functional analysis of Fgf signaling revealed precise reciprocal interactions, which showed that mesenchymal Fgf10 rather than Fgf7 modulates tongue epithelial differentiation via Fgfr2b in a temporal- and spatial-specific manner. © 2011 Springer-Verlag.
Persistent Identifierhttp://hdl.handle.net/10722/169584
ISSN
2013 Impact Factor: 3.333
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSohn, WJen_US
dc.contributor.authorJung, HIen_US
dc.contributor.authorChoi, MAen_US
dc.contributor.authorHan, JHen_US
dc.contributor.authorGwon, GJen_US
dc.contributor.authorYamamoto, Hen_US
dc.contributor.authorLee, Sen_US
dc.contributor.authorRyoo, ZYen_US
dc.contributor.authorPark, EKen_US
dc.contributor.authorShin, HIen_US
dc.contributor.authorJung, HSen_US
dc.contributor.authorKim, JYen_US
dc.date.accessioned2012-10-25T04:53:10Z-
dc.date.available2012-10-25T04:53:10Z-
dc.date.issued2011en_US
dc.identifier.citationCell And Tissue Research, 2011, v. 345 n. 2, p. 265-273en_US
dc.identifier.issn0302-766Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/169584-
dc.description.abstractThe molecular mechanisms for epithelial differentiation have been studied by observing skin development in embryogenesis, but the early signaling modulations involved in tongue epithelial differentiation are not completely understood. Based on the gene expression patterns of the Fgf signaling molecules and previous results from Fgf10 and Fgfr2b knockout mice, it was hypothesized that there would be fundamental signaling interactions through the epithelial Fgfr2b and its mesenchymal ligand Fgf10 to regulate tongue epithelium differentiation. To elucidate these reciprocal interactions in tongue epithelial differentiation, this study employed an in vitro tongue organ culture system with antisense-oligodeoxynucleotides (AS-ODNs) and recombinant protein-soaked bead implantation for the loss-of-function and gain-of-function studies. Functional analysis of Fgf signaling revealed precise reciprocal interactions, which showed that mesenchymal Fgf10 rather than Fgf7 modulates tongue epithelial differentiation via Fgfr2b in a temporal- and spatial-specific manner. © 2011 Springer-Verlag.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htmen_US
dc.relation.ispartofCell and Tissue Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Differentiation - Physiologyen_US
dc.subject.meshEpithelial Cells - Cytology - Metabolismen_US
dc.subject.meshFibroblast Growth Factor 10 - Genetics - Metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Icren_US
dc.subject.meshMice, Knockouten_US
dc.subject.meshReceptor, Fibroblast Growth Factor, Type 2 - Genetics - Metabolismen_US
dc.subject.meshSignal Transductionen_US
dc.subject.meshTongue - Cytology - Metabolismen_US
dc.titleReciprocal interactions of Fgf10/Fgfr2b modulate the mouse tongue epithelial differentiationen_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00441-011-1204-8en_US
dc.identifier.pmid21720756en_US
dc.identifier.scopuseid_2-s2.0-80052698289en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052698289&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume345en_US
dc.identifier.issue2en_US
dc.identifier.spage265en_US
dc.identifier.epage273en_US
dc.identifier.isiWOS:000293401400007-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridSohn, WJ=44161404800en_US
dc.identifier.scopusauthoridJung, HI=25929998200en_US
dc.identifier.scopusauthoridChoi, MA=7402093527en_US
dc.identifier.scopusauthoridHan, JH=37125883200en_US
dc.identifier.scopusauthoridGwon, GJ=52463597100en_US
dc.identifier.scopusauthoridYamamoto, H=36046310100en_US
dc.identifier.scopusauthoridLee, S=35242624000en_US
dc.identifier.scopusauthoridRyoo, ZY=16937104900en_US
dc.identifier.scopusauthoridPark, EK=37071072400en_US
dc.identifier.scopusauthoridShin, HI=24377179200en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US
dc.identifier.scopusauthoridKim, JY=34870132800en_US
dc.identifier.citeulike9513875-

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