Article: Reciprocal interactions of Fgf10/Fgfr2b modulate the mouse tongue epithelial differentiation

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TitleReciprocal interactions of Fgf10/Fgfr2b modulate the mouse tongue epithelial differentiation
AuthorsSohn, WJ3
Jung, HI3
Choi, MA3
Han, JH3
Gwon, GJ3
Yamamoto, H1
Lee, S3
Ryoo, ZY3
Park, EK3
Shin, HI3
Jung, HS2
Kim, JY3
Issue Date2011
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
CitationCell And Tissue Research, 2011, v. 345 n. 2, p. 265-273 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00441-011-1204-8
AbstractThe molecular mechanisms for epithelial differentiation have been studied by observing skin development in embryogenesis, but the early signaling modulations involved in tongue epithelial differentiation are not completely understood. Based on the gene expression patterns of the Fgf signaling molecules and previous results from Fgf10 and Fgfr2b knockout mice, it was hypothesized that there would be fundamental signaling interactions through the epithelial Fgfr2b and its mesenchymal ligand Fgf10 to regulate tongue epithelium differentiation. To elucidate these reciprocal interactions in tongue epithelial differentiation, this study employed an in vitro tongue organ culture system with antisense-oligodeoxynucleotides (AS-ODNs) and recombinant protein-soaked bead implantation for the loss-of-function and gain-of-function studies. Functional analysis of Fgf signaling revealed precise reciprocal interactions, which showed that mesenchymal Fgf10 rather than Fgf7 modulates tongue epithelial differentiation via Fgfr2b in a temporal- and spatial-specific manner. © 2011 Springer-Verlag.
ISSN0302-766X
2011 Impact Factor: 3.114
2011 SCImago Journal Rankings: 0.333
DOIhttp://dx.doi.org/10.1007/s00441-011-1204-8
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorSohn, WJ
dc.contributor.authorJung, HI
dc.contributor.authorChoi, MA
dc.contributor.authorHan, JH
dc.contributor.authorGwon, GJ
dc.contributor.authorYamamoto, H
dc.contributor.authorLee, S
dc.contributor.authorRyoo, ZY
dc.contributor.authorPark, EK
dc.contributor.authorShin, HI
dc.contributor.authorJung, HS
dc.contributor.authorKim, JY
dc.date.accessioned2012-10-25T04:53:10Z
dc.date.available2012-10-25T04:53:10Z
dc.date.issued2011
dc.description.abstractThe molecular mechanisms for epithelial differentiation have been studied by observing skin development in embryogenesis, but the early signaling modulations involved in tongue epithelial differentiation are not completely understood. Based on the gene expression patterns of the Fgf signaling molecules and previous results from Fgf10 and Fgfr2b knockout mice, it was hypothesized that there would be fundamental signaling interactions through the epithelial Fgfr2b and its mesenchymal ligand Fgf10 to regulate tongue epithelium differentiation. To elucidate these reciprocal interactions in tongue epithelial differentiation, this study employed an in vitro tongue organ culture system with antisense-oligodeoxynucleotides (AS-ODNs) and recombinant protein-soaked bead implantation for the loss-of-function and gain-of-function studies. Functional analysis of Fgf signaling revealed precise reciprocal interactions, which showed that mesenchymal Fgf10 rather than Fgf7 modulates tongue epithelial differentiation via Fgfr2b in a temporal- and spatial-specific manner. © 2011 Springer-Verlag.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationCell And Tissue Research, 2011, v. 345 n. 2, p. 265-273 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00441-011-1204-8
dc.identifier.citeulike9513875
dc.identifier.doihttp://dx.doi.org/10.1007/s00441-011-1204-8
dc.identifier.epage273
dc.identifier.issn0302-766X
2011 Impact Factor: 3.114
2011 SCImago Journal Rankings: 0.333
dc.identifier.issue2
dc.identifier.pmid21720756
dc.identifier.scopuseid_2-s2.0-80052698289
dc.identifier.spage265
dc.identifier.urihttp://hdl.handle.net/10722/169584
dc.identifier.volume345
dc.languageeng
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
dc.publisher.placeGermany
dc.relation.ispartofCell and Tissue Research
dc.relation.referencesReferences in Scopus
dc.subject.meshAnimals
dc.subject.meshCell Differentiation - Physiology
dc.subject.meshEpithelial Cells - Cytology - Metabolism
dc.subject.meshFibroblast Growth Factor 10 - Genetics - Metabolism
dc.subject.meshMice
dc.subject.meshMice, Inbred Icr
dc.subject.meshMice, Knockout
dc.subject.meshReceptor, Fibroblast Growth Factor, Type 2 - Genetics - Metabolism
dc.subject.meshSignal Transduction
dc.subject.meshTongue - Cytology - Metabolism
dc.titleReciprocal interactions of Fgf10/Fgfr2b modulate the mouse tongue epithelial differentiation
dc.typeArticle
Author Affiliations
  1. Nihon University
  2. Yonsei University
  3. Kyungpook National University