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Article: Importance of region-specific epithelial rearrangements in mouse rugae development
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TitleImportance of region-specific epithelial rearrangements in mouse rugae development
 
AuthorsSohn, WJ3
Yamamoto, H2
Shin, HI3
Ryoo, ZY3
Lee, S3
Bae, YC3
Jung, HS1
Kim, JY3
 
Issue Date2011
 
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
 
CitationCell And Tissue Research, 2011, v. 344 n. 2, p. 271-277 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00441-011-1148-z
 
AbstractEpithelial appendages on palatal rugae develop during mouse palatogenesis through epithelial thickening and pattern formation. Recently, the patterned formation of nine rugae was observed together with the specific expression patterns of Shh in rodents. However, no crucial evidence was found for a direct association between Shh expression and the distinct structural formation of rugae. In order to reveal possible relationships, we investigated the morphological changes of rugae and expression patterns of Shh directly by in vitro organ culture at embryonic day 13 (E13) for 2 days. To compare and examine the diverse growing aspects of the palate and rugae, we carefully observed the detailed morphogenesis, with cell proliferation of the rugae occurring between E13 and E14.5. After 2 days of cultivation at E13, DiI micro-injections revealed that the middle part of the palate, adjacent to the upper molar-forming region, contributed to the formation of the subsequent structure of rugae by extensive cell rearrangement and proliferation within the epithelium in the preferred anteroposterior direction. The results also defined the intimate relationship between Shh expression and rugae formation. © 2011 Springer-Verlag.
 
ISSN0302-766X
2013 Impact Factor: 3.333
 
DOIhttp://dx.doi.org/10.1007/s00441-011-1148-z
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorSohn, WJ
 
dc.contributor.authorYamamoto, H
 
dc.contributor.authorShin, HI
 
dc.contributor.authorRyoo, ZY
 
dc.contributor.authorLee, S
 
dc.contributor.authorBae, YC
 
dc.contributor.authorJung, HS
 
dc.contributor.authorKim, JY
 
dc.date.accessioned2012-10-25T04:53:07Z
 
dc.date.available2012-10-25T04:53:07Z
 
dc.date.issued2011
 
dc.description.abstractEpithelial appendages on palatal rugae develop during mouse palatogenesis through epithelial thickening and pattern formation. Recently, the patterned formation of nine rugae was observed together with the specific expression patterns of Shh in rodents. However, no crucial evidence was found for a direct association between Shh expression and the distinct structural formation of rugae. In order to reveal possible relationships, we investigated the morphological changes of rugae and expression patterns of Shh directly by in vitro organ culture at embryonic day 13 (E13) for 2 days. To compare and examine the diverse growing aspects of the palate and rugae, we carefully observed the detailed morphogenesis, with cell proliferation of the rugae occurring between E13 and E14.5. After 2 days of cultivation at E13, DiI micro-injections revealed that the middle part of the palate, adjacent to the upper molar-forming region, contributed to the formation of the subsequent structure of rugae by extensive cell rearrangement and proliferation within the epithelium in the preferred anteroposterior direction. The results also defined the intimate relationship between Shh expression and rugae formation. © 2011 Springer-Verlag.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationCell And Tissue Research, 2011, v. 344 n. 2, p. 271-277 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00441-011-1148-z
 
dc.identifier.citeulike8997937
 
dc.identifier.doihttp://dx.doi.org/10.1007/s00441-011-1148-z
 
dc.identifier.epage277
 
dc.identifier.issn0302-766X
2013 Impact Factor: 3.333
 
dc.identifier.issue2
 
dc.identifier.pmid21400215
 
dc.identifier.scopuseid_2-s2.0-79958286125
 
dc.identifier.spage271
 
dc.identifier.urihttp://hdl.handle.net/10722/169581
 
dc.identifier.volume344
 
dc.languageeng
 
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
 
dc.publisher.placeGermany
 
dc.relation.ispartofCell and Tissue Research
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAnimals
 
dc.subject.meshEpithelium - Embryology - Metabolism
 
dc.subject.meshFemale
 
dc.subject.meshHedgehog Proteins - Biosynthesis - Genetics
 
dc.subject.meshImmunohistochemistry
 
dc.subject.meshMale
 
dc.subject.meshMice
 
dc.subject.meshMice, Inbred Icr
 
dc.subject.meshPalate - Embryology - Metabolism
 
dc.subject.meshPregnancy
 
dc.titleImportance of region-specific epithelial rearrangements in mouse rugae development
 
dc.typeArticle
 
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<contributor.author>Lee, S</contributor.author>
<contributor.author>Bae, YC</contributor.author>
<contributor.author>Jung, HS</contributor.author>
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Author Affiliations
  1. Yonsei University
  2. Nihon University
  3. Kyungpook National University