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Article: Importance of region-specific epithelial rearrangements in mouse rugae development

TitleImportance of region-specific epithelial rearrangements in mouse rugae development
Authors
Issue Date2011
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
Citation
Cell And Tissue Research, 2011, v. 344 n. 2, p. 271-277 How to Cite?
Abstract
Epithelial appendages on palatal rugae develop during mouse palatogenesis through epithelial thickening and pattern formation. Recently, the patterned formation of nine rugae was observed together with the specific expression patterns of Shh in rodents. However, no crucial evidence was found for a direct association between Shh expression and the distinct structural formation of rugae. In order to reveal possible relationships, we investigated the morphological changes of rugae and expression patterns of Shh directly by in vitro organ culture at embryonic day 13 (E13) for 2 days. To compare and examine the diverse growing aspects of the palate and rugae, we carefully observed the detailed morphogenesis, with cell proliferation of the rugae occurring between E13 and E14.5. After 2 days of cultivation at E13, DiI micro-injections revealed that the middle part of the palate, adjacent to the upper molar-forming region, contributed to the formation of the subsequent structure of rugae by extensive cell rearrangement and proliferation within the epithelium in the preferred anteroposterior direction. The results also defined the intimate relationship between Shh expression and rugae formation. © 2011 Springer-Verlag.
Persistent Identifierhttp://hdl.handle.net/10722/169581
ISSN
2013 Impact Factor: 3.333
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSohn, WJen_US
dc.contributor.authorYamamoto, Hen_US
dc.contributor.authorShin, HIen_US
dc.contributor.authorRyoo, ZYen_US
dc.contributor.authorLee, Sen_US
dc.contributor.authorBae, YCen_US
dc.contributor.authorJung, HSen_US
dc.contributor.authorKim, JYen_US
dc.date.accessioned2012-10-25T04:53:07Z-
dc.date.available2012-10-25T04:53:07Z-
dc.date.issued2011en_US
dc.identifier.citationCell And Tissue Research, 2011, v. 344 n. 2, p. 271-277en_US
dc.identifier.issn0302-766Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/169581-
dc.description.abstractEpithelial appendages on palatal rugae develop during mouse palatogenesis through epithelial thickening and pattern formation. Recently, the patterned formation of nine rugae was observed together with the specific expression patterns of Shh in rodents. However, no crucial evidence was found for a direct association between Shh expression and the distinct structural formation of rugae. In order to reveal possible relationships, we investigated the morphological changes of rugae and expression patterns of Shh directly by in vitro organ culture at embryonic day 13 (E13) for 2 days. To compare and examine the diverse growing aspects of the palate and rugae, we carefully observed the detailed morphogenesis, with cell proliferation of the rugae occurring between E13 and E14.5. After 2 days of cultivation at E13, DiI micro-injections revealed that the middle part of the palate, adjacent to the upper molar-forming region, contributed to the formation of the subsequent structure of rugae by extensive cell rearrangement and proliferation within the epithelium in the preferred anteroposterior direction. The results also defined the intimate relationship between Shh expression and rugae formation. © 2011 Springer-Verlag.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htmen_US
dc.relation.ispartofCell and Tissue Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEpithelium - Embryology - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshHedgehog Proteins - Biosynthesis - Geneticsen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Icren_US
dc.subject.meshPalate - Embryology - Metabolismen_US
dc.subject.meshPregnancyen_US
dc.titleImportance of region-specific epithelial rearrangements in mouse rugae developmenten_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00441-011-1148-zen_US
dc.identifier.pmid21400215en_US
dc.identifier.scopuseid_2-s2.0-79958286125en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79958286125&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume344en_US
dc.identifier.issue2en_US
dc.identifier.spage271en_US
dc.identifier.epage277en_US
dc.identifier.isiWOS:000290167600009-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridSohn, WJ=44161404800en_US
dc.identifier.scopusauthoridYamamoto, H=36046310100en_US
dc.identifier.scopusauthoridShin, HI=24377179200en_US
dc.identifier.scopusauthoridRyoo, ZY=16937104900en_US
dc.identifier.scopusauthoridLee, S=35242624000en_US
dc.identifier.scopusauthoridBae, YC=7201466016en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US
dc.identifier.scopusauthoridKim, JY=34870132800en_US
dc.identifier.citeulike8997937-

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