Article: Importance of region-specific epithelial rearrangements in mouse rugae development

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TitleImportance of region-specific epithelial rearrangements in mouse rugae development
AuthorsSohn, WJ3
Yamamoto, H1
Shin, HI3
Ryoo, ZY3
Lee, S3
Bae, YC3
Jung, HS2
Kim, JY3
Issue Date2011
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
CitationCell And Tissue Research, 2011, v. 344 n. 2, p. 271-277 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00441-011-1148-z
AbstractEpithelial appendages on palatal rugae develop during mouse palatogenesis through epithelial thickening and pattern formation. Recently, the patterned formation of nine rugae was observed together with the specific expression patterns of Shh in rodents. However, no crucial evidence was found for a direct association between Shh expression and the distinct structural formation of rugae. In order to reveal possible relationships, we investigated the morphological changes of rugae and expression patterns of Shh directly by in vitro organ culture at embryonic day 13 (E13) for 2 days. To compare and examine the diverse growing aspects of the palate and rugae, we carefully observed the detailed morphogenesis, with cell proliferation of the rugae occurring between E13 and E14.5. After 2 days of cultivation at E13, DiI micro-injections revealed that the middle part of the palate, adjacent to the upper molar-forming region, contributed to the formation of the subsequent structure of rugae by extensive cell rearrangement and proliferation within the epithelium in the preferred anteroposterior direction. The results also defined the intimate relationship between Shh expression and rugae formation. © 2011 Springer-Verlag.
ISSN0302-766X
2011 Impact Factor: 3.114
2011 SCImago Journal Rankings: 0.333
DOIhttp://dx.doi.org/10.1007/s00441-011-1148-z
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorSohn, WJ
dc.contributor.authorYamamoto, H
dc.contributor.authorShin, HI
dc.contributor.authorRyoo, ZY
dc.contributor.authorLee, S
dc.contributor.authorBae, YC
dc.contributor.authorJung, HS
dc.contributor.authorKim, JY
dc.date.accessioned2012-10-25T04:53:07Z
dc.date.available2012-10-25T04:53:07Z
dc.date.issued2011
dc.description.abstractEpithelial appendages on palatal rugae develop during mouse palatogenesis through epithelial thickening and pattern formation. Recently, the patterned formation of nine rugae was observed together with the specific expression patterns of Shh in rodents. However, no crucial evidence was found for a direct association between Shh expression and the distinct structural formation of rugae. In order to reveal possible relationships, we investigated the morphological changes of rugae and expression patterns of Shh directly by in vitro organ culture at embryonic day 13 (E13) for 2 days. To compare and examine the diverse growing aspects of the palate and rugae, we carefully observed the detailed morphogenesis, with cell proliferation of the rugae occurring between E13 and E14.5. After 2 days of cultivation at E13, DiI micro-injections revealed that the middle part of the palate, adjacent to the upper molar-forming region, contributed to the formation of the subsequent structure of rugae by extensive cell rearrangement and proliferation within the epithelium in the preferred anteroposterior direction. The results also defined the intimate relationship between Shh expression and rugae formation. © 2011 Springer-Verlag.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationCell And Tissue Research, 2011, v. 344 n. 2, p. 271-277 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00441-011-1148-z
dc.identifier.citeulike8997937
dc.identifier.doihttp://dx.doi.org/10.1007/s00441-011-1148-z
dc.identifier.epage277
dc.identifier.issn0302-766X
2011 Impact Factor: 3.114
2011 SCImago Journal Rankings: 0.333
dc.identifier.issue2
dc.identifier.pmid21400215
dc.identifier.scopuseid_2-s2.0-79958286125
dc.identifier.spage271
dc.identifier.urihttp://hdl.handle.net/10722/169581
dc.identifier.volume344
dc.languageeng
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
dc.publisher.placeGermany
dc.relation.ispartofCell and Tissue Research
dc.relation.referencesReferences in Scopus
dc.subject.meshAnimals
dc.subject.meshEpithelium - Embryology - Metabolism
dc.subject.meshFemale
dc.subject.meshHedgehog Proteins - Biosynthesis - Genetics
dc.subject.meshImmunohistochemistry
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshMice, Inbred Icr
dc.subject.meshPalate - Embryology - Metabolism
dc.subject.meshPregnancy
dc.titleImportance of region-specific epithelial rearrangements in mouse rugae development
dc.typeArticle
Author Affiliations
  1. Nihon University
  2. Yonsei University
  3. Kyungpook National University