File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Interactions between Shh, Sostdc1 and Wnt signaling and a new feedback loop for spatial patterning of the teeth

TitleInteractions between Shh, Sostdc1 and Wnt signaling and a new feedback loop for spatial patterning of the teeth
Authors
Issue Date2011
PublisherThe Company of Biologists Ltd. The Journal's web site is located at http://dev.biologists.org
Citation
Development, 2011, v. 138 n. 9, p. 1807-1816 How to Cite?
AbstractEach vertebrate species displays specific tooth patterns in each quadrant of the jaw: the mouse has one incisor and three molars, which develop at precise locations and at different times. The reason why multiple teeth form in the jaw of vertebrates and the way in which they develop separately from each other have been extensively studied, but the genetic mechanism governing the spatial patterning of teeth still remains to be elucidated. Sonic hedgehog (Shh) is one of the key signaling molecules involved in the spatial patterning of teeth and other ectodermal organs such as hair, vibrissae and feathers. Sostdc1, a secreted inhibitor of the Wnt and Bmp pathways, also regulates the spatial patterning of teeth and hair. Here, by utilizing maternal transfer of 5E1 (an anti-Shh antibody) to mouse embryos through the placenta, we show that Sostdc1 is downstream of Shh signaling and suggest a Wnt-Shh-Sostdc1 negative feedback loop as a pivotal mechanism controlling the spatial patterning of teeth. Furthermore, we propose a new reaction-diffusion model in which Wnt, Shh and Sostdc1 act as the activator, mediator and inhibitor, respectively, and confirm that such interactions can generate the tooth pattern of a wild-type mouse and can explain the various tooth patterns produced experimentally. © 2011.
Persistent Identifierhttp://hdl.handle.net/10722/169580
ISSN
2015 Impact Factor: 6.059
2015 SCImago Journal Rankings: 5.239
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCho, SWen_US
dc.contributor.authorKwak, Sen_US
dc.contributor.authorWoolley, TEen_US
dc.contributor.authorLee, MJen_US
dc.contributor.authorKim, EJen_US
dc.contributor.authorBaker, REen_US
dc.contributor.authorKim, HJen_US
dc.contributor.authorShin, JSen_US
dc.contributor.authorTickle, Cen_US
dc.contributor.authorMaini, PKen_US
dc.contributor.authorJung, HSen_US
dc.date.accessioned2012-10-25T04:53:06Z-
dc.date.available2012-10-25T04:53:06Z-
dc.date.issued2011en_US
dc.identifier.citationDevelopment, 2011, v. 138 n. 9, p. 1807-1816en_US
dc.identifier.issn0950-1991en_US
dc.identifier.urihttp://hdl.handle.net/10722/169580-
dc.description.abstractEach vertebrate species displays specific tooth patterns in each quadrant of the jaw: the mouse has one incisor and three molars, which develop at precise locations and at different times. The reason why multiple teeth form in the jaw of vertebrates and the way in which they develop separately from each other have been extensively studied, but the genetic mechanism governing the spatial patterning of teeth still remains to be elucidated. Sonic hedgehog (Shh) is one of the key signaling molecules involved in the spatial patterning of teeth and other ectodermal organs such as hair, vibrissae and feathers. Sostdc1, a secreted inhibitor of the Wnt and Bmp pathways, also regulates the spatial patterning of teeth and hair. Here, by utilizing maternal transfer of 5E1 (an anti-Shh antibody) to mouse embryos through the placenta, we show that Sostdc1 is downstream of Shh signaling and suggest a Wnt-Shh-Sostdc1 negative feedback loop as a pivotal mechanism controlling the spatial patterning of teeth. Furthermore, we propose a new reaction-diffusion model in which Wnt, Shh and Sostdc1 act as the activator, mediator and inhibitor, respectively, and confirm that such interactions can generate the tooth pattern of a wild-type mouse and can explain the various tooth patterns produced experimentally. © 2011.en_US
dc.languageengen_US
dc.publisherThe Company of Biologists Ltd. The Journal's web site is located at http://dev.biologists.orgen_US
dc.relation.ispartofDevelopmenten_US
dc.subject.meshAnimalsen_US
dc.subject.meshBody Patterning - Genetics - Physiologyen_US
dc.subject.meshBone Morphogenetic Proteins - Genetics - Metabolism - Physiologyen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshComputer Simulationen_US
dc.subject.meshEmbryo, Mammalianen_US
dc.subject.meshEpistasis, Genetic - Physiologyen_US
dc.subject.meshFeedback, Physiological - Physiologyen_US
dc.subject.meshHedgehog Proteins - Genetics - Metabolism - Physiologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Knockouten_US
dc.subject.meshMice, Nudeen_US
dc.subject.meshModels, Theoreticalen_US
dc.subject.meshOdontogenesis - Genetics - Physiologyen_US
dc.subject.meshSignal Transduction - Genetics - Physiologyen_US
dc.subject.meshTooth - Embryology - Metabolismen_US
dc.subject.meshWnt Proteins - Genetics - Metabolism - Physiologyen_US
dc.titleInteractions between Shh, Sostdc1 and Wnt signaling and a new feedback loop for spatial patterning of the teethen_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1242/dev.056051en_US
dc.identifier.pmid21447550-
dc.identifier.scopuseid_2-s2.0-79955411359en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79955411359&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume138en_US
dc.identifier.issue9en_US
dc.identifier.spage1807en_US
dc.identifier.epage1816en_US
dc.identifier.isiWOS:000289406900015-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridCho, SW=32967447200en_US
dc.identifier.scopusauthoridKwak, S=7202607781en_US
dc.identifier.scopusauthoridWoolley, TE=36775733100en_US
dc.identifier.scopusauthoridLee, MJ=35264472100en_US
dc.identifier.scopusauthoridKim, EJ=36064163200en_US
dc.identifier.scopusauthoridBaker, RE=7404218884en_US
dc.identifier.scopusauthoridKim, HJ=36065539800en_US
dc.identifier.scopusauthoridShin, JS=7402724236en_US
dc.identifier.scopusauthoridTickle, C=7005294923en_US
dc.identifier.scopusauthoridMaini, PK=7007021673en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats