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Article: Expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisor

TitleExpression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisor
Authors
Issue Date2011
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/modgep
Citation
Gene Expression Patterns, 2011, v. 11 n. 3-4, p. 163-170 How to Cite?
AbstractRecent studies have demonstrated the existence of dental stem cells in the continuously growing tooth. However, much remains to be learned about the complex mechanism involving stem cells during tooth development. We determined the expression patterns of four stem cell markers ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisors between embryonic day (E) 11 and postnatal day (PN) 20. ABCG2 was localized strongly in the perivascular region of the incisor mesenchyme from E11 to PN20, and in the odontoblasts from E18 to PN20. Bmi-1 was expressed in both the dental epithelium and mesenchyme from E11 to E14. The expression of Bmi-1 was noticeably reduced at E16, and was restricted to the apical bud from E16 to PN20. Oct-3/4 was localized in the nucleus of the cells in the superficial layer and stellate reticulum within the dental epithelium from E11 to E14 and in the apical bud from E16 to PN20. Meanwhile, once the ameloblasts and odontoblasts began to appear at E16, they expressed Oct-3/4 in the cytoplasm. Yap was expressed in most of the basal cells of the incisor dental epithelium from E11 to E14, but was expressed mainly in the transit-amplifying (TA) cells within the basal cell layer from E16 to PN20. The unique and overlapping expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap suggest the independent and interactive functions of the four stem cell markers in the developing mouse incisor. © 2010 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/169577
ISSN
2015 Impact Factor: 1.485
2015 SCImago Journal Rankings: 0.985
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Len_US
dc.contributor.authorKwon, HJen_US
dc.contributor.authorHarada, Hen_US
dc.contributor.authorOhshima, Hen_US
dc.contributor.authorCho, SWen_US
dc.contributor.authorJung, HSen_US
dc.date.accessioned2012-10-25T04:53:03Z-
dc.date.available2012-10-25T04:53:03Z-
dc.date.issued2011en_US
dc.identifier.citationGene Expression Patterns, 2011, v. 11 n. 3-4, p. 163-170en_US
dc.identifier.issn1567-133Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/169577-
dc.description.abstractRecent studies have demonstrated the existence of dental stem cells in the continuously growing tooth. However, much remains to be learned about the complex mechanism involving stem cells during tooth development. We determined the expression patterns of four stem cell markers ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisors between embryonic day (E) 11 and postnatal day (PN) 20. ABCG2 was localized strongly in the perivascular region of the incisor mesenchyme from E11 to PN20, and in the odontoblasts from E18 to PN20. Bmi-1 was expressed in both the dental epithelium and mesenchyme from E11 to E14. The expression of Bmi-1 was noticeably reduced at E16, and was restricted to the apical bud from E16 to PN20. Oct-3/4 was localized in the nucleus of the cells in the superficial layer and stellate reticulum within the dental epithelium from E11 to E14 and in the apical bud from E16 to PN20. Meanwhile, once the ameloblasts and odontoblasts began to appear at E16, they expressed Oct-3/4 in the cytoplasm. Yap was expressed in most of the basal cells of the incisor dental epithelium from E11 to E14, but was expressed mainly in the transit-amplifying (TA) cells within the basal cell layer from E16 to PN20. The unique and overlapping expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap suggest the independent and interactive functions of the four stem cell markers in the developing mouse incisor. © 2010 Elsevier B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/modgepen_US
dc.relation.ispartofGene Expression Patternsen_US
dc.subject.meshAtp-Binding Cassette Transporters - Genetics - Metabolismen_US
dc.subject.meshAdaptor Proteins, Signal Transducing - Genetics - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntigens, Differentiation - Metabolismen_US
dc.subject.meshDental Papilla - Embryology - Growth & Development - Metabolismen_US
dc.subject.meshEmbryonic Stem Cells - Metabolismen_US
dc.subject.meshEpithelium - Embryology - Growth & Development - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expression Regulation, Developmentalen_US
dc.subject.meshIncisor - Embryology - Growth & Development - Metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Icren_US
dc.subject.meshNuclear Proteins - Genetics - Metabolismen_US
dc.subject.meshOctamer Transcription Factor-3 - Genetics - Metabolismen_US
dc.subject.meshPhosphoproteins - Genetics - Metabolismen_US
dc.subject.meshProto-Oncogene Proteins - Genetics - Metabolismen_US
dc.subject.meshRepressor Proteins - Genetics - Metabolismen_US
dc.titleExpression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisoren_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.gep.2010.11.001en_US
dc.identifier.pmid21073982-
dc.identifier.scopuseid_2-s2.0-79953055220en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79953055220&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume11en_US
dc.identifier.issue3-4en_US
dc.identifier.spage163en_US
dc.identifier.epage170en_US
dc.identifier.isiWOS:000289693500001-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLi, L=46761189900en_US
dc.identifier.scopusauthoridKwon, HJ=18836582500en_US
dc.identifier.scopusauthoridHarada, H=7402619046en_US
dc.identifier.scopusauthoridOhshima, H=7202879991en_US
dc.identifier.scopusauthoridCho, SW=32967447200en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US
dc.identifier.citeulike8258892-

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