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Article: Lung tissue regeneration after induced injury in Runx3 KO mice.

TitleLung tissue regeneration after induced injury in Runx3 KO mice.
Authors
KeywordsCcsp
Hsp70
Mouse (Runx3 Knockout)
Perk
Pjnk
Runx3 Ko
Smad3
Tgf-Β1
Wound Healing
Issue Date2010
Citation
Cell And Tissue Research, 2010, v. 341 n. 3, p. 465-470 How to Cite?
AbstractRunx3 is essential for normal murine lung development, and Runx3 knockout (KO) mice, which die soon after birth, exhibit alveolar hyperplasia. Wound healing, tissue repair, and regeneration mechanisms are necessary in humans for proper early lung development. Previous studies have reported that various signaling molecules, such as pErk, Tgf-beta1, CCSP, pJnk, Smad3, and HSP70 are closely related to wound healing. In order to confirm the relationship between lung defects caused by the loss of function of Runx3 and wound healing, we have localized various wound-healing markers after laser irradiation in wild-type and in Runx3 KO mouse lungs at post-natal day 1. Our results indicate that pERK, Tgf-beta1, CCSP, pJnk, and HSP70 are dramatically down-regulated by loss of Runx3 during lung wound healing. However, Smad3 is up-regulated in the Runx3 KO laser-irradiated lung region. Therefore, the lung wound-healing mechanism is inhibited in the Runx3 KO mouse, which shows abnormal lung architecture, by reduced pErk, Tgf-beta1, CCSP, pJnk, and HSP70 and by induced Smad3.
Persistent Identifierhttp://hdl.handle.net/10722/169575
ISSN
2015 SCImago Journal Rankings: 1.539
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, JMen_US
dc.contributor.authorKwon, HJen_US
dc.contributor.authorBae, SCen_US
dc.contributor.authorJung, HSen_US
dc.date.accessioned2012-10-25T04:53:02Z-
dc.date.available2012-10-25T04:53:02Z-
dc.date.issued2010en_US
dc.identifier.citationCell And Tissue Research, 2010, v. 341 n. 3, p. 465-470en_US
dc.identifier.issn1432-0878en_US
dc.identifier.urihttp://hdl.handle.net/10722/169575-
dc.description.abstractRunx3 is essential for normal murine lung development, and Runx3 knockout (KO) mice, which die soon after birth, exhibit alveolar hyperplasia. Wound healing, tissue repair, and regeneration mechanisms are necessary in humans for proper early lung development. Previous studies have reported that various signaling molecules, such as pErk, Tgf-beta1, CCSP, pJnk, Smad3, and HSP70 are closely related to wound healing. In order to confirm the relationship between lung defects caused by the loss of function of Runx3 and wound healing, we have localized various wound-healing markers after laser irradiation in wild-type and in Runx3 KO mouse lungs at post-natal day 1. Our results indicate that pERK, Tgf-beta1, CCSP, pJnk, and HSP70 are dramatically down-regulated by loss of Runx3 during lung wound healing. However, Smad3 is up-regulated in the Runx3 KO laser-irradiated lung region. Therefore, the lung wound-healing mechanism is inhibited in the Runx3 KO mouse, which shows abnormal lung architecture, by reduced pErk, Tgf-beta1, CCSP, pJnk, and HSP70 and by induced Smad3.en_US
dc.languageengen_US
dc.relation.ispartofCell and tissue researchen_US
dc.subjectCcsp-
dc.subjectHsp70-
dc.subjectMouse (Runx3 Knockout)-
dc.subjectPerk-
dc.subjectPjnk-
dc.subjectRunx3 Ko-
dc.subjectSmad3-
dc.subjectTgf-Β1-
dc.subjectWound Healing-
dc.subject.meshAnimalsen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshCore Binding Factor Alpha 3 Subunit - Geneticsen_US
dc.subject.meshLasersen_US
dc.subject.meshLung - Metabolism - Pathology - Physiology - Radiation Effectsen_US
dc.subject.meshLung Injury - Genetics - Pathology - Physiopathology - Rehabilitationen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C57blen_US
dc.subject.meshMice, Knockouten_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshOrgan Culture Techniquesen_US
dc.subject.meshRadiation Injuries, Experimental - Pathology - Physiopathology - Rehabilitationen_US
dc.subject.meshRegeneration - Genetics - Physiologyen_US
dc.subject.meshSignal Transduction - Geneticsen_US
dc.subject.meshSmad3 Protein - Genetics - Metabolismen_US
dc.subject.meshTransforming Growth Factor Beta - Genetics - Metabolismen_US
dc.subject.meshTransforming Growth Factor Beta1 - Genetics - Metabolismen_US
dc.subject.meshWound Healing - Genetics - Physiologyen_US
dc.titleLung tissue regeneration after induced injury in Runx3 KO mice.en_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00441-010-1011-7-
dc.identifier.pmid20623301en_US
dc.identifier.scopuseid_2-s2.0-79952117740en_US
dc.identifier.volume341en_US
dc.identifier.issue3en_US
dc.identifier.spage465en_US
dc.identifier.epage470en_US
dc.identifier.isiWOS:000281670800012-
dc.identifier.scopusauthoridLee, JM=35269112200en_US
dc.identifier.scopusauthoridKwon, HJ=18836582500en_US
dc.identifier.scopusauthoridBae, SC=7202714699en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US
dc.identifier.citeulike7498091-

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