File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Characteristics of ethylnitrosourea-induced cataracts

TitleCharacteristics of ethylnitrosourea-induced cataracts
Authors
Issue Date2009
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/02713683.asp
Citation
Current Eye Research, 2009, v. 34 n. 5, p. 360-368 How to Cite?
AbstractPurpose: This study analyzed genes associated with the morphology and regulation of ethylnitrosourea (ENU)-induced cataract mouse. Materials and Methods: Immunohistochemistry analysis using anti-crystallins and PCNA antibody revealed that the localization pattern of these specific markers differed between the cataractous and wild-type lens epithelium. Two-dimensional electrophoresis and microarray techniques were used to identify the proteins and genes related to ENU-induced cataract. Results: A novel ENU-induced mutation in the mouse led to nuclear and cortical opacity of the eye lens at 5 weeks postnatal. This cataract phenotype was similar to that of the zonular-pulverulent type of human cataract. Crystallin proteins and gap-junction genes have relations to the formation of cataract. Conclusions: Together, the results suggest that various proteins affect the formation and specific phenotypes of ENU-induced cataract mouse.
Persistent Identifierhttp://hdl.handle.net/10722/169560
ISSN
2014 Impact Factor: 1.639
2013 SCImago Journal Rankings: 0.977
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, MJen_US
dc.contributor.authorKim, JYen_US
dc.contributor.authorKim, YJen_US
dc.contributor.authorCho, JWen_US
dc.contributor.authorCho, KHen_US
dc.contributor.authorSong, CWen_US
dc.contributor.authorJung, HSen_US
dc.date.accessioned2012-10-25T04:52:52Z-
dc.date.available2012-10-25T04:52:52Z-
dc.date.issued2009en_US
dc.identifier.citationCurrent Eye Research, 2009, v. 34 n. 5, p. 360-368en_US
dc.identifier.issn0271-3683en_US
dc.identifier.urihttp://hdl.handle.net/10722/169560-
dc.description.abstractPurpose: This study analyzed genes associated with the morphology and regulation of ethylnitrosourea (ENU)-induced cataract mouse. Materials and Methods: Immunohistochemistry analysis using anti-crystallins and PCNA antibody revealed that the localization pattern of these specific markers differed between the cataractous and wild-type lens epithelium. Two-dimensional electrophoresis and microarray techniques were used to identify the proteins and genes related to ENU-induced cataract. Results: A novel ENU-induced mutation in the mouse led to nuclear and cortical opacity of the eye lens at 5 weeks postnatal. This cataract phenotype was similar to that of the zonular-pulverulent type of human cataract. Crystallin proteins and gap-junction genes have relations to the formation of cataract. Conclusions: Together, the results suggest that various proteins affect the formation and specific phenotypes of ENU-induced cataract mouse.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/02713683.aspen_US
dc.relation.ispartofCurrent Eye Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCataract - Chemically Induced - Genetics - Metabolism - Pathologyen_US
dc.subject.meshConnexins - Geneticsen_US
dc.subject.meshCrystallins - Genetics - Metabolismen_US
dc.subject.meshDna Mutational Analysisen_US
dc.subject.meshElectrophoresis, Gel, Two-Dimensionalen_US
dc.subject.meshEthylnitrosoureaen_US
dc.subject.meshEye Proteins - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Balb Cen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshProliferating Cell Nuclear Antigen - Metabolismen_US
dc.subject.meshProtein Array Analysisen_US
dc.subject.meshTissue Distributionen_US
dc.titleCharacteristics of ethylnitrosourea-induced cataractsen_US
dc.typeArticleen_US
dc.identifier.emailJung, HS: hsjung@yuhs.acen_US
dc.identifier.authorityJung, HS=rp01683en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1080/02713680902843047en_US
dc.identifier.pmid19401879en_US
dc.identifier.scopuseid_2-s2.0-67649649885en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67649649885&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume34en_US
dc.identifier.issue5en_US
dc.identifier.spage360en_US
dc.identifier.epage368en_US
dc.identifier.isiWOS:000265581500005-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLee, MJ=35264472100en_US
dc.identifier.scopusauthoridKim, JY=7601361822en_US
dc.identifier.scopusauthoridKim, YJ=16833275700en_US
dc.identifier.scopusauthoridCho, JW=34869479800en_US
dc.identifier.scopusauthoridCho, KH=8450197800en_US
dc.identifier.scopusauthoridSong, CW=7403253231en_US
dc.identifier.scopusauthoridJung, HS=7403030195en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats